Monografie navazuje na předešlou Kopečkovu práci Éra nevinnosti: Česká politika 1989-1997 (Brno, Barrister & Principal 2010) a pojednává o okolnostech a důsledcích takzvané opoziční smlouvy, kterou po volbách v roce 1998 uzavřely dvě největší české politické strany - sociální demokracie pod vedením Miloše Zemana a Občanská demokratická strana v čele s Václavem Klausem - o podmínkách tolerance Zemanovy vlády Klausovou opozicí. Předmětem politologického výkladu jsou jak hlavní aktéři tohoto mocenského paktu, tak početná opozice proti němu, které se podařilo zabránit, aby se proměnil ve stabilní systém dominance dvou stran. Přes až přílišnou závislost na žurnalistických pramenech představuje Deformace demokracie? podle recenzenta spolu s autorovou předešlou publikací základní syntézu o českém politickém vývoji po pádu komunistického režimu., The publication under review, whose title translates as "A deformation of democracy? The opposition agreement and Czech politics, 1998-2002", follows on from Kopeček´s Éra nevinnosti: Česká politika 1989-1997 (The age of innocence. Czech politics 1989-97, Brno: Barrister a. Principal, 2010). It is concerned with the circumstances and consequences of what was popularly known as the Opposition Agreement, which, after the general elections of 1998, was signed by the two largest Czech political parties - the Social Democratic Party, led by Miloš Zeman (b. 1944), and the Civic Democratic Party, led by Václav Klaus (b. 1941) - and concerns the terms and conditions under which the Klaus-led opposition would tolerate the Zeman-led government. The focus of this political-science interpretation is not only the main actors of the agreement but also the large opposition to it. The latter ultimately succeeded in preventing the pact from leading to a system run by only two parties. Despite its excessive dependence on journalistic sources, the publication, according to the reviewer, constitutes, together with the author´s preceding volume, a fundamental work on Czech political developments since the collapse of the Communist regime., [autor recenze] Petr Roubal., and Obsahuje bibliografii a bibliografické odkazy
One of the most abundant immunologic cell types in early decidua is the uterine natural killer (UNK) cell that despite the presence of cytoplasmic granules rich in perforin and granzymes does not degranulate in normal pregnancy. UNK cells are important producers of angiogenic factors that permit normal dilation of uterine arteries to provide increased blood flow for the growing feto-placental unit. Gram-negative bacteria lipopolysaccharide (LPS) administration can trigger an imbalance of pro-inflammatory and anti-inflammatory cytokines impairing the normal immune cells activity as well as uterine homeostasis. The present study aimed to evaluate by immunohistochemistry the reactivity of perforin and α-actin on UNK cell from LPStreated pregnant mice. For the first time, we demonstrate that LPS injection in pregnant mice causes α-actin down regulation, concomitantly with perforin loss in UNK cells. This suggests that LPS alters UNK cell migration and activates cytotoxic granule release., B. Zavan, A. M. do Amarante-Paffaro, V. A. Paffaro Jr., and Obsahuje bibliografii