The article follows the spread of the cult of St Maurice in the Czech lands, where it penetrated apparently from the monastery of St Maurice in Niederaltaich. The chapel in the episcopal palace at Prague Castle might have been consecrated to him under Bishop Severus (Šebíř), primarily Bishop of Olomouc Bruno of Schauenburg was responsible for its spread in Moravia. The spread of the cult was helped also by Maurice´s reliquaries, deposited from the middle 12th century in the cathedral in Prague. In the 14th century, Charles IV brought a sword of St Maurice to Prague, which was part of the imperial treasury. The transport of the body of St Sigismund (1365), the founder of the Abbey of St Maurice d´Augane, was also important for the expansion of the cult in Bohemia. The study also follows all of the medieval artistic monuments that are connected with the cult., Petr Kubín., and Obsahuje literaturu a odkazy pod čarou
Streptozotocin (STZ) is used to induce experimental diabetes in animals and is also applied for the treatment of patients with insulinoma. The aim of the present work was to investigate the direct effect of STZ on lipolysis in isolated rat adipocytes. After the isolation, the cells were incubated in a Krebs-Ringer buffer of pH 7.4, at the temperature 37 °C for 90 min with different concentrations of STZ: 0.5, 1 or 2 mmol/l. STZ caused a significant rise in basal values (99 %, 199 %, and 377 %, respectively) and epinephrine-stimulated (1 µmol/l) lipolysis (15 %, 24 % and 46 %, respectively). Augmentation of basal lipolysis by STZ was neither restricted by insulin (1 nmol/l) nor by H-89 (an inhibitor of protein kinase A, 50 µmol/l). These results indicate the stimulatory influence of STZ on the action of hormone-sensitive lipase in isolated cells of white adipose tissue. The obtained outcomes suggest that in studies employing STZ, it is necessary to consider its direct effect upon lipolysis in adipocytes., T. Szkudelski, K. Szkudelska., and Obsahuje bibliografii