Search

Start Over Subject 615 Harvested from CDK Harvested from CDK Data provider Academy of Sciences Library/Knihovna Akademie věd ČR

1. Lapidář rukopisu Vodňanského: literární a kulturně-historická studie : k dějinám drog ve 14. století v Čechách

Creator:
Šedivý, Emil
Publisher:
Emil Šedivý and [Čsl. lékárnická společnost]
Format:
print and 45 s.
Type:
model:monograph and TEXT
Subject:
Farmacie. Farmakologie, 14. století, drogy, dějiny, Česko, 14, and 615
Language:
Czech and French
Description:
Emil Šedivý., Francouzské resumé, and Seaprát z Časopisu čsl. lékarnictva, r. 25, 1906
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

2. Miotic action of tramadol is determined by CYP2D6 genotype

Creator:
Ondřej Slanař, Milan Nobilis, Jaroslav Květina, Rudolf Mikoviny, Tomáš Zima, Jeffrey R. Idle, and František Perlík
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Farmacie. Farmakologie, farmakokinetika, cytochromy, genotyp, pharmacokinetics, cytochromes, genotype, cytochrom P450 2D6, miosa, tramadol, cytochrome P450 2D6, miosis, 14, and 615
Language:
English
Description:
Polymorphic CYP2D6 is the enzyme that activates the opioid analgesic tramadol by O-demethylation to its active metabolite O-demethyltramadol (M1). Our objective was to determine the opioid effects measured by pupillary response to tramadol of CYP2D6 genotyped volunteers in relation to the disposition of tramadol and M1 in plasma. Tramadol displayed phenotypic pharmacokinetics and it was possible to identify poor metabolizers (PM) with >99 % confidence from the metabolic ratio (MR) in a single blood sample taken between 2.5 and 24 h post-dose. Homozygous extensive metabolizers (EM) differed from PM subjects by an almost threefold greater (P=0.0014) maximal pupillary constriction (Emax). Significant correlations between the AUC and Cmax values of M1 versus pupillary constriction were found. The corresponding correlations of pharmacokinetic parameters for tramadol itself were weaker and negative. The strongest correlations were for the single-point metabolic ratios at all sampling intervals versus the effects, with rs ranging from 0.85 to 0.89 (p‹0.01). It is concluded that the concept of dual opioid/non-opioid action of the drug, though considerably stronger in EMs, is valid for both EM and PM subjects. This is the theoretical basis for the frequent use and satisfactory efficacy of tramadol in clinical practice when given to genetically non-selected population., O. Slanař, M. Nobilis, J. Květina, R. Mikoviny, T. Zima, J. R. Idle, F. Perlík., and Obsahuje biblografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public