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13292. CAPITALE IN PEDILAVIO BALNEUM, Pro Septem CAPITALIBUS Vitjs ...
- Creator:
- Gregor Georg de Kriegelstein and Jezuitská tiskárna (Praha, Česko)
- Publisher:
- Tiskárna jezuitská
- Format:
- print and 14 pp ; 4°
- Type:
- model:monograph and TEXT
- Subject:
- <z >Valdštejna, Jan Bedřich, 1644-1694, století 17., homiletika, chrám sv. Víta, Praha (Česko), Vyšehrad (Praha, Česko), Stará Boleslav (Česko), obřady církevní, pedilavium, obřad mytí nohou, and 094
- Language:
- Latin
- Description:
- Královská kanonie premonstrátů na Strahově - Strahovská knihovna Praha CZ BR V 42 adl. num. 49, Královská kanonie premonstrátů na Strahově - Strahovská knihovna Praha CZ BU II 128 adl. num. 2, Národní knihovna ČR Praha CZ 34 D 367, Klášter dominikánů - knihovna Praha CZ E VI 111 adl. 1, Klášter Rytířského řádu křižovníků s červenou hvězdou - knihovna Praha CZ XVI H 10 adl. num. 2, Klášter Rytířského řádu křižovníků s červenou hvězdou - knihovna Praha CZ XVI H 8 adl. num. 24, CZ Praha Metropolitní kapitula u sv. Víta v Praze C.d.B.45 adl. 1, and BCBT31830
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
13293. Capra aegagrus ad scat. aur. q. s.
- Creator:
- Miltner, Vladimír
- Format:
- Type:
- model:internalpart and TEXT
- Language:
- Czech
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
13294. Capsaicin-induced membrane currents in cultured sensory neurons of the rat
- Creator:
- Vlachová, V. and Vyklický, L.
- Type:
- article, model:article, and TEXT
- Subject:
- sensory neurons, rat, capsaicin, GABA, membrane currents, and primary culture
- Language:
- English
- Description:
- Membrane currents induced by capsaicin (CAPS) in cultured sensory neurons from 1- to 2-day-old rats were studied. Responses to CAPS (lO^M) exceeding 1 nA at -50 mV were found in smaller, usually bipolar or tripolar neurons in which GABA (30 yuM) induced small or no response. Large, unipolar neurons, which exhibited large responses to GABA, were completely insensitive to CAPS (10//M). In contrast to GABA, responses to CAPS exhibited a slow rise and slow decay and a marked tachyphylaxis after repeated CAPS applications at high concentrations which made it difficult to study the concentration-response relationship. In partially run-down neurons, which exhibited quasi stable responses, the slope of the ascending phase was concentration-dependent with an apparent association rate constant Ki 9x104 [M-1s-1]. The time constant of the decay was 3.5 s, and was concentration-independent. However, in 5 neurones the EC50 measured from the first series of CAPS applications at increasing concentrations was 0.31 ±0.5ptA with a Hill coefficient 1.66±0.35. The responses to CAPS reversed at +10.4±2.5 mV suggesting that the current is carried nonselectively by monovalent cations and Ca2+. The channel conductance of CAPS-gated channels at -50 mV calculated from the mean membrane current and variance of the current noise in outside-out patches or measured directly was 28 pS (n=5). It is suggested that the CAPS-gated channels are either controlled by receptors with a very high affinity or that the channels are controlled by membrane-bound protein(s) which do not depend in their function on the supply of GTP or other intracellular metabolites.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
13295. Capsazepine affects thermal preferences of the American cockroach (Blattodea: Blattidae)
- Creator:
- Maliszewska, Justyna and Tęgowska, Eugenia
- Format:
- print, počítač, and online zdroj
- Type:
- article, články, journal articles, model:article, and TEXT
- Subject:
- Zoologie, švábovití, Blattidae, Blattodea, American cockroach, behavioural thermoregulation, capsaicin, capsazepine, TRPV, 2, and 59
- Language:
- English
- Description:
- Capsazepine is a competitive antagonist of capsaicin, a TRPV1 agonist responsible for the spicy taste of pepper. TRPV1 agonists and antagonists are known to affect mammalian body temperature, but their action on thermoregulation in insects is poorly known. In this study we evaluated the effect of capsazepine on the thermal preference of the American cockroach, Periplaneta americana using a thermal gradient. Our results revealed that capsazepine in submicromolar concentrations induces a preference for higher ambient temperatures when compared to the control insects. To assess whether capsazepine may act also as an antagonist of capsaicin in insects, we determined this insects' thermal behaviour when capsazepine was applied before capsaicin. The hypothermic response to capsaicin was clearly blocked by pre-treatment with capsazepine only in female American cockroaches. Our results indicate the involvement of structures functionally similar to TRPV1 in insect thermosensation., Justyna Maliszewska, Eugenia Tęgowska., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
13296. Captopril attenuates proteosynthesis in the aorta and decreases endothelaemia in rabbits with aortic insufficiency
- Creator:
- Šimko, F., Pecháňová, O., Bernátová, I., Holécyová, A., Šimko, J., and Sochorová, R.
- Type:
- article, model:article, and TEXT
- Subject:
- aortic insufficiency, aorta, proteosynthesis, endothelaemia, and relaxation
- Language:
- English
- Description:
- The effect of the angiotensin converting enzyme (ACE) inhibitor, captopril, on proteosynthesis in the aorta, acetylcholine-stimulated aortic relaxation and endothelaemia (circulating endothelial cells) was investigated in rabbits with aortic insufficiency. The animals were studied 28 days after experimental intervention. Cardiac volume overload stimulated proteosynthesis in the aorta as reflected by increased ribonucleic acid (RNA) concentration and [14C] leucine incorporation into proteins of the aorta. Moreover, the number of endothelial cells in the blood was increased. The administration of captopril starting from the second day of the haemodynamic overload, partially prevented the increase both in aortic proteosynthesis and in endothelaemia. Despite these alterations, the relaxing ability of the aorta to acetylcholine was not changed either by the haemodynamic overload or by captopril. We conclude that the increase of proteosynthesis in the aorta and of endothelaemia in the early period of chronic cardiac volume overload in rabbits were partially prevented by chronic captopril treatment. Neither aortic insufficiency nor captopril changed the acetylcholine-induced relaxation of the aorta.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
13297. Captopril Fails to Reverse Hypertrophy of the Left Ventricle Induced by Aortic Insufficiency in Rabbits
- Creator:
- Fedor Šimko, Václav Pelouch, and Ján Kyselovič
- Format:
- print, bez média, and svazek
- Type:
- article, studie, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Aortic insufficiency, Hypertrophy regression, Fibrosis, Cardiac hypertrophy, 14, and 612
- Language:
- English
- Description:
- Angiotensin converting enzyme (ACE) inhibition has been reported to induce regression of hypertrophy in several models of hemodynamic pressure overload. The aim of the present study was to determine whether the ACE inhibitor captopril can reduce hypertrophy of the left ventricle induced by a chronic volume overload and modify collagen composition of the hypertrophied myocardium. Rabbits with four months lasting aortic insufficiency were divided into two groups: treated with captopril (20 mg/kg/day) for five weeks and treated with placebo. The respective control groups were represented by sham-operated animals. Aortic insufficiency induced a decrease of diastolic pressure, an increase of systolic and pulse pressure, hypertrophy of the left and right ventricle, and an increase of hydroxyproline content in the left ventricle without a change of hydroxyproline concentrations in either ventricle. Captopril treatment further enhanced pulse pressure by decreasing diastolic blood pressure. Hypertrophy of the left ventricle, hydroxyproline content and concentration in both ventricles were unaffected by captopril treatment. It is concluded that ACE inhibition did not reverse the left ventricular hypertrophy developed as a result of overload induced by aortic insufficiency. We suggest that mechanisms different from activation of the renin-angiotensin system may play a decisive role in the maintenance of hypertrophy in this particular model of volume hemodynamic overload., F. Šimko, V. Pelouch, J. Kyselovic., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
13298. Captopril partially decreases the effect of H2S on rat blood pressure and inhibits H2S-induced nitric oxide release from S-nitrosoglutathione
- Creator:
- Drobná, M., Misak, A., Holland, T., Kristek, F., Grman, M., Tomasova, L., Berenyiova, A., Cacanyiova, S., and Ondrias, K.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, sulfan, oxid dusnatý, krevní tlak, srdeční rytmus, hydrogen sulphide, nitric oxide, blood pressure, heart rate, captopril, H2S, 14, and 612
- Language:
- English
- Description:
- We studied the effects of the H2S donor Na2S on the mean arterial blood pressure (MAP) and heart and breathing rates of anesthetized Wistar rats in the presence and absence of captopril. Bolus administration of Na2S (1-4 μmol/kg) into the right jugular vein transiently decreased heart and increased breathing rates; at 8-30 μmol/kg, Na2S had a biphasic effect, transiently decreasing and increasing MAP, while transiently decreasing heart rate and increasing and decreasing breathing rate. These results may indicate independent mechanisms by which H2S influences MAP and heart and breathing rates. The effect of Na2S in decreasing MAP was less pronounced in the presence of captopril (2 μmol/l), which may indicate that the renin-angiotensin system is partially involved in the Na2S effect. Captopril decreased H2S-induced NO release from S-nitrosoglutathione, which may be related to some biological activities of H2S. These results contribute to the understanding of the effects of H2S on the cardiovascular system., M. Drobná, A. Misak, T. Holland, F. Kristek, M. Grman, L. Tomasova, A. Berenyiova, S. Cacanyiova, K. Ondrias., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
13299. Captopril prevents NO-deficient hypertension and left ventricular hypertrophy without affecting nitric oxide synthase activity in rats
- Creator:
- Bernátová, I., Pecháňová, O., and Šimko, F.
- Type:
- article, model:article, and TEXT
- Subject:
- nitric oxide synthase, captopril, L-NAME, angiotensin II, hypertrophy, and hypertension
- Language:
- English
- Description:
- The aim of the study was to assess whether angiotensin converting enzyme (ACE) inhibition with captopril prevents the development of hypertension and myocardial hypertrophy and affects nitric oxide synthase (NOS) activity in rats. Animals were divided into five groups: control, two groups receiving NG-nitro-L-arginine methyl ester (L-NAME) 20 or 40 mg/kg/day, a group receiving captopril 100 mg/kg/day and a group concomitantly treated with 40 mg/kg/day L-NAME plus 100 mg/kg/day captopril. After four weeks, systolic blood pressure (SBP) significantly increased in both L-NAME groups by 30 % and 34 %, respectively. In the captopril group, SBP significantly decreased by 30 % and in the captopril plus L-NAME group SBP was not changed as compared to the controL Although left ventricular weight/body weight (LVW/BW) ratio in both L-NAME groups was significantly elevated by 19 % and 29 %, respectively, no alterations in LVW/BW ratio were found in the captopril group and captopril plus L-NAME group. In both groups receiving L-NAME, NOS activity significantly decreased by 17 % and 69 % in the heart, by 14 % and 26 % in the aorta, by 60 % and 73 % in the brain and by 13 % and 30 % in the kidney, respectively. Captopril did not influence NO synthase activity in any of the studied tissues. We conclude that captopril prevents the development of hypertension and LV hypertrophy without affecting NO formation.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
13300. Car simulation and virtual environments for investigation of driver behavior
- Creator:
- Bouchner, Petr, Hajný , Michal, Novotný , Stanislav, Piekník , Roman, and Sojka, Jan
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- Driving simulation, driving safety, EEG, attention decrase, and driving in virtual environments
- Language:
- English
- Description:
- The operator is required to be constantly vigilant and even more attentive when operating the device. The paper introduces a cooperation of a car simulator realized in the virtual reality (VR) environments and measurements of "human driver behavior" focused mainly on the aspects of HMI and drivers' attention decrease. In the first part a conception and a development of our VR car simulation devices are described. During the development of the car simulators many problems need to be solved. One of these problems is represented by a simplification and a partial automation of a scenery creation. The first part is dedicated to the algorithms used in our tools, which help to automate the creation of virtual scenes. The next part analyses, in greater detail, the tools themselves and the rest of this section deals with demonstration of the scenes, which were modeled using these tools. For simpler and faster generation of virtual sceneries it is suitable to store the models within a hierarchical database 3D object. Our database includes model objects from which it subsequently forms surroundings for the road virtual scenes. In the article is described how to specify the 3D model properties - their fundamental characteristic and consequent differentiation into specific categories. Sound perception cues are one of the most important ones besides the visual cues in the car simulation. The audio section of this article deals with simulating a sound of a car engine as a most significant audio stimulant for the driver. It shows the basics of the cross fading system which renders the car audio from multiple looped samples. The first part contains an analysis of car engine sound, the second part describes how to synthesize it on the computer. Validation measurements and consequent results are shown at the end of this section. The final paragraphs show examples of experiments developed for measurements of the driver's fatigue and other aspects of the driver's behavior.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public