The paper follows from the theory of explosion and interaction of an impact wave formed by the explosion and a structure..As a rule, a number of simplifying assumptions must be applied as regards the characteristics of the explosion and of the threatened structure to analyze the structure. As example of dynamic analysis of a new reinforced concrete structure, loaded with a blast wave was used to apply the principles of simpflified ingineering analysis of an explosion-loaded structure. The way of structure failure was analyzed based on time courses of calculated internal forces and displacenets of individual structure elements. The criteria of structural elements failure due to explosion load effects were determined as a part of the dynamic structure response assessment. and Obsahuje seznam literatury
The influence of chronic angiotensin ATi receptor blockade by specific antibody on the development of genetic hypertension was studied in young spontaneously hypertensive rats (SHR). The immunization of 4-week-old SHR with a small part of the angiotensin ATi receptor molecule attenuated the development of hypertension in these animals. After five subcutaneous injections of the antigen both systolic and diastolic blood pressures were significantly lower (p<0.005) in immunized SHR compared to sham- immunized SHR. No effect on blood pressure was seen in immunized Wistar-Kyoto control rats. We conclude that renin-angiotensin system might be partially involved in the development of hypertension in young spontaneously hypertensive rats because it can be attenuated by a specific antibody raised against a part of the angiotensin ATi receptor.