Author gives the history of the Danish main outpost on Coromandel Coast of India from its inception to the sale to English EIC. Against the background of its territorial development, its relationship with the Indian authorities, the role in business networks and the position in the Danish colonies net he depicts an overview of architectural and cultural development of the city and its role as a center of missionary activity., Michal Wanner., and Obsahuje seznam literatury a poznámky
Článek se zabývá Levinasovou ideou „transcendence slov“. Sleduje úvahy tohoto autora o rozdílu mezi významem slov ve vztahu k Jinému a rolí slov v estetické události obrazu. Soustřeďuje se na Levinasovo zdůraznění kontrastu mezi tichem obrazu a zvukem dialogu., Dealing with Levinas’s idea of the “transcendence of words”, the article follows his treatment of the difference between the meaning of the words in relation to the Other and the role of the words in the aesthetic event of the image. The focus is on the way that Levinas emphasises the contrast between the silence of an image and the sound of a dialogue., and Miloš Ševčík.
Ve studii „Transcendence slov“ se Emmanual Levinas zabývá charakterem literárního obrazu. Porovnává ho s malbou a zdůrazňuje vizuální povahu obou těchto obrazů. Ticho těchto obrazů je však překonáno skandálem zaznívajících slov, která subjekt nabízí Jinému., In his study ‘The Transcendence of Words’, Emmanuel Levinas deals with the character of the literary image. He compares it with painting and emphasises the visual nature of both these images. However, the silence of both these images is overcome by the scandal of the resounding words which the subject offers to the Other., and Emmanuel Levinas.
The high prevalence of obesity and related metabolic complications has inspired research on adipose tissues. Three kinds of adipose tissues are identified in mammals: brown adipose tissue (BAT), beige or brite adipose tissue and white adipose tissue (WAT). Beige adipocytes share some characteristics with brown adipocytes such as the expression of UCP1. Beige adipocytes can be activated by environmental stimuli or pharmacological treatment, and this change is accompanied by an increase in energy consumption. This process is called white browning, and it facilitates the maintenance of a lean and healthy phenotype. Thus, promoting beige adipocyte development in WAT shows promise as a new strategy in treating obesity and related metabolic consequences. In this review, we summarized the current understanding of the regulators and hormones that participate in the development of brown fat and white fat browning., Jianmei Zhang, Huixiao Wu, Shizhan Ma, Fei Jing, Chunxiao Yu, Ling Gao, Jiajun Zhao., and Obsahuje bibliografii
Metabolic syndrome and one of its manifestations, essential hypertension, is an important cause of worldwide morbidity and mortality. Morbidity and mortality associated with hypertension are caused by organ complications. Previously we revealed a decrease of blood pressure and an amelioration of cardiac fibrosis in a congenic line of spontaneously hypertensive rats (SHR), in which a short segment of chromosome 8 (encompassing only 7 genes) was exchanged for a segment of normotensive polydactylous (PD) origin. To unravel the genetic background of this phenotype we compared heart transcriptomes between SHR rat males and this chromosome 8 minimal congenic line (PD5). We found 18 differentially expressed genes, which were further analyzed using annotations from Database for Annotation, Visualization and Integrated Discovery (DAVID). Four of the differentially expressed genes (Per1, Nr4a1, Nr4a3, Kcna5) belong to circadian rhythm pathways, aldosterone synthesis and secretion, PI3K-Akt signaling pathway and potassium homeostasis. We were also able to confirm Nr4a1 2.8x-fold upregulation in PD5 on protein level using Western blotting, thus suggesting a possible role of Nr4a1 in pathogenesis of the metabolic syndrome.
Covid-19 or SARS-CoV-2, a new RNA virus with high infectivity, and seemingly low mutability, which appeared in 2019 in the Wuhan province of China, has created a pandemic with dire consequences. At the end of May 2020, it became the first cause of mortality. As no treatment or vaccine may become available before many months, and because occurrence of similar pandemics is only a matter of time, arguments are presented here for testing the effect of transfer factor (TF), an immunomodulator devoid of toxicity, which has been extensively studied in the past for the treatment and prevention of viral infections.
Motto Strategie AV21 „Špičkový výzkum ve veřejném zájmu“ mj. předesílá podporu mezioborové a meziinstitucionální synergie více než 50 pracovišť Akademie věd. Právě proto, aby výzkum opravdu sloužil společnosti, otevřela Akademie věd nové Centrum transferu technologií, jehož prostory se hostům slavnostně představily 16. května 2016. and Marina Hužvárová.