Endovaskulární terapie (EVT) je nejúčinnější metoda léčby akutního uzávěru velké tepny (arteria carotis interna, arteria cerebri media, arteria basilaris). Recentně publikované prospektivní randomizované kontrolované studie porovnávající kombinovanou EVT a medikamentózní léčbu (intravenózní trombolýzu; IVT) prokázaly superioritu kombinované EVT a IVT oproti samotné IVT v terapii akutních ischemických příhod v karotickém povodí. Cílem naší práce je podat přehled sedmi studií publikovaných v letech 2014–2015. V druhé části pojednáváme o faktorech, které ovlivňují výsledný klinický stav: věk, komorbidity, hyperglykemie při příjmu, známky časné ischemie na CT hodnocené pomocí Alberta Stroke Program Early CT Score (ASPECTS), absence kolaterálního zásobení, doba do dosažení rekanalizace a použití celkové anestezie. Úspěch EVT závisí na správném výběru vhodných pacientů., The endovascular therapy (EVT) is the most efficacious treatment for recanalisation of large vessel artery occlusion. Recently published prospective randomized controlled trials (RCT) demonstrated better outcomes with combined EVT and intravenous thrombolysis (IVT) versus IVT alone in the treatment of proximal arterial occlusion in the anterior cerebral circulation. In this article seven of these RCT studies published in 2014 - 2015 are reviewed. In the latter part of the article, the factors influencing final clinical outcome are discussed: age, comorbidities, hyperglycemia on admission, signs of early ischemia as evaluaed by Alberta Stroke Program Early CT Score (ASPECTS), absence of collateral supply, time before recanalisation occurs and application general anesthesia. The careful selection of patients indicated for EVT is of utmost importance for the succes of therapy. Key words: acute ischemic stroke – endovascular therapy – mechanical thrombectomy – stent-retriever The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers., and M. Tinková, P. Malý
Background: Obstetric complications developing at antiphospholipid syndrome are serious medical-social problem. Seeking of the treatment methods sets conditions for urgency of the article reviewed. Enzyme preparations are widely applied for treatment of women with fecundity disorder and hemorheology changes. Research objective was in clinico-laboratorial evaluation of Serrata drug impact in antiphospholipid syndrome in women with reproductive losses of Andijan state. Methods: Data of 43 women in the non-pregnancy state with reproductive losses (RL) in past history with revealed APS had been studied by us. Results: Thus, conducted therapy with Serrata was conductive to haemostasis. Conducted researches confirm the safety of application., Gulnoza Maniyozova, Habiba Negmatshaeva, Ozoda Yuldasheva, Gulnoza Turaeva, Dilfura Parpieva, and Literatura