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Start Over Date 2010 Harvested from CDK

635. Testování HER-2/neu u karcinomu žaludku - nová výzva i naděje?

Creator:
Ryška, Aleš, Rozkoš, Tomáš, and Laco, Jan
Type:
model:article, article, Text, přehledy, and TEXT
Subject:
lidé, nádory žaludku--diagnóza--patologie--terapie, receptor erbB-2, prognóza, karcinom žaludku, HER-2/neu, c-erbB-2, imunohistochemie, and in situ hybridizace
Language:
Czech and English
Description:
Karcinom žaludku je ve světě druhou nejčastější příčinou úmrtí na malignitu. V rámci jednotlivých stadií může být prognóza nádoru velmi rozdílná, proto se zájem onkologů upíná k hledání nových prognostických a prediktivních markerů, jako je např. HER-2/neu (HER2). Po jeho stimulaci dochází k nastartování signální dráhy, vedoucí ke zvýšené proliferaci, zablokování apoptózy, ztrátě diferenciace a zvýšení invazivity nádoru. HER2 je negativním prognostickým faktorem, sdruženým s vyšší invazivitou, postižením serózy, metastazováním do uzlin a kratším přežitím, i negativním prediktivním faktorem a cílem pro biologickou léčbu trastuzumabem. Existují dvě metody detekce HER2 – imunohistochemie (IHC) a in situ hybridizace (ISH). Pozitivita HER2 se u karcinomu žaludku pohybuje v rozmezí 6,8–34 % (průměrně 17,6 %) při stanovení IHC, resp. 7,1–42,6 % (průměrně 19,2 %) pomocí ISH. HER2 je častěji přítomen v intestinálním, než v difuzním typu karcinomu. Při stanovení HER2 platí některá specifika – za pozitivní považovány jak buňky s kompletní, tak s pouze bazolaterální expresí proteinu, vzhledem k častěji nehomogenní expresi je dolní hranice v resekátech 10 % pozitivních buněk, ale u endobioptických vzorků je vyžadována přítomnost alespoň jedné skupiny barvících se (2+ nebo 3+) neoplastických buněk., Gastric carcinoma is the second cause of cancer related death worldwide. Prognosis significantly varies among patients within the same stage, therefore oncologists urge for identification of new prognostic and predictive markers, such as HER-2/neu (HER2). Stimulation of HER2 triggers molecular pathway resulting in increased proliferation, blocked apoptosis, loss of differentiation and increased tumor invasion. HER2 is a negative prognostic factor, associated with increased invasiveness, serosal involvement, lymph-node metastases and shorter survival, as well as a negative predictive marker and target for trastuzumab treatment. There are two methods of HER2 detection – immunohistochemistry (IHC) and in situ hybridisation (ISH). Positivity of HER2 in gastric cancer ranges from 6,8 to 34 % (mean 17,6 %) in IHC detection, and 7,1–42,6 % (mean 19,2 %) in ISH detection, respectively. HER2 is more often positive in intestinal than in diffuse type. HER2 detection in gastric carcinoma shows certain specific features – positive cells show either complete or incomplete basolateral (Ushaped) membranous expression. Due to more frequent inhomogenity of tumor population, the threshold has been set at 10 % of positive cells in resection specimens, but even one cohesive cluster of positive (2+ or 3+) neoplastic cells is sufficient in biopsy samples., Aleš Ryška, Tomáš Rozkoš, Jan Laco, and Lit.: 24
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

638. The combined operation the cancer of the rectum with germination in genital organs

Creator:
Bobokulov, H. B. and Hakimov, A. M.
Format:
braille, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, statistics, and TEXT
Subject:
nádory rekta--komplikace--terapie, nádory ženských pohlavních orgánů--terapie, chirurgie operační--metody, výsledek terapie, dospělí, staří, ženské pohlaví, lidé, lidé středního věku, and mladý dospělý
Language:
English
Description:
The Purpose of the study: define the indications and contraindications to, combined operation in locally invasive tumor of the rectum. The Material and methods of the study: we have analysed results combined operation in cancer of the rectum with germination in genital organs, performed in department of coloproctology in National Oncological Scientific centre during 20052009 years. Under observation were 118 women at age from 21 to 68 years. This before 45 years 26 patients, from 46 to 59 years 54 patients, 60 and above years. The Results and their discussion: Postoperative complications suppurativeinflammatory character appeared beside 36 patients (30,5%), most of all after abdomeno perineal extirpation of rectum (35,5%) and abdominoanal resection of the rectum (33,3%). In lesser extend after front resection of the rectum and after operation Hartman (28,5% and 22,7%). The General lethality has formed 3,4%, have died after combined operation 4 patients from 118 operated patients. The Conclusion: thereby, brought data evident that such important factors, as frequency of the origin relapse (28%), 5year probability of survival (37,1%), under combined interference and operation of the standard volume in the cancer of the rectum practically the same., H. B. Bobokulov, A. M. Hakimov, and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

639. The disease girshprunga beside adult: modern approaches to diagnostics & treatment

Creator:
Mirzahmedov, M. M., Ahmedov, M. A., and Sapaev, D. A.
Format:
braille, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, statistics, and TEXT
Subject:
Hirschsprungova nemoc--diagnóza--terapie, popis nemoci, příznaky a symptomy, pooperační komplikace, výsledek terapie, mladiství, dospělí, ženské pohlaví, lidé, mužské pohlaví, lidé středního věku, and mladý dospělý
Language:
English
Description:
The Material of the study has formed 78 sick, found on stationary treatment in Republican Scientific Centre Coloproktologii since 1992 on 2010. As it is seen, from table, from 78 sick mans was 58(74,3%), womans 20(25,7%). 19(24,3), sick were at age from 15 before 20 years, 49(60,2%) at age from 21 before 40 years and 13 (16,6%) sick from 41 before 60 years. The Main complaint sick at arrival were a stubborn constipations, which noted beside 70 (89,7%) sick, including absence of the independent chair existed beside 55(70,5%), but beside 54(69,2%) sick were noted periodic stomachache, growing on measure of the absence of the chair. The Ballooned belly existed beside all 78 (100%) sick moreover beside 20(25,6%) of them flatulence was constant. The Sickness and retching existed beside 24(30,7%), weakness, reduction to capacity to work beside 52(66,6%), increasing of the temperature of the body beside 10(12,8%), paradoxical diarrhoeas beside 6(7,6%) sick. Endoskopicheskiy method (rectoromonoscopy, colonoscopy) turned out to be else less informations 51,8% coincidences of the diagnosis. So we biopsy on Svensonu executed beside all sick, entered with suspicion on disease Girshprunga. In our observations from 78 sick beside 42(53,8,1%) were aboveanalni, beside 20(25,6%) sick rectalis, beside 13(16,6%)rectosigmoideys , beside 2(2,5%) leftside and beside 1(1,2%) sick subtotalis form hipoganglios. At biopsies on Svensonu on observations, from 78 sick, beside 44(56,4%) is revealled hipoganglios, but beside 35(44,8%) аganglios rectum. As can be seen from presented tables, from 78 sick beside 68(87,2%) us is executed onemoments radical operation, 10(12,8%) sick is as far as possible made resection hipoor aganglionarnaya of the zone, decompensate part of the large intestine and is formed colostomy. In all events at operations. The Remote results executed radical operation on cause disease Girshprunga traced from 1 before 10 years beside 57(73%) sick. The Results of the surgical treatment were valued on scale Vezika: good, satisfactory and unsatisfactory. In our observations beside 46(80,7%) sick results came in well, beside 10(17,5%) satisfactory and beside 1(1,8%) sick was an unsatisfactory result., Mirzahmedov M. M., Ahmedov M. A., Sapaev D. A., and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

640. The effect of time in a multi-dimensional marriage market model

Creator:
Vozár, Mário, Kejak, Michal, Univerzita Karlova. Centrum pro ekonomický výzkum a doktorské studium, and Národohospodářský ústav (Akademie věd ČR)
Publisher:
CERGE-EI
Format:
electronic and 32 s.
Type:
model:monograph and TEXT
Subject:
Sociální interakce. Sociální komunikace, partnerské vztahy, stárnutí, rozvod, matematické modelování, 316.472.42, 612.67, 364.642, 519.673, (048.8), 18, and 316.4/.7
Language:
English
Description:
Mário Vozár., Evropský sociální fond Praha & EU: Investujeme do vaší budoucnosti, and born digital
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

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