Již podruhé se v bubenečské vile Lanně sešli odborníci zabývající se historickými astronomickými deskami. První setkání se konalo před dvěma lety, kdy se diskutovaly problémy desek sužovaných degradací emulze vlivem dlouhého a často nešetrného skladování - letošní akce se zúčastnilo 44 odborníků z 20 zemí od Mexika až po Čínu. and Petr Skala.
The atherogenic impact and functional capacity of LCAT was studied and discussed over a half century. This review aims to clarify the key points that may affect the final decision on whether LCAT is an anti-atherogenic or atherogenic factor. There are three main processes involving the efflux of free cholesterol from peripheral cells, LCAT action in intravascular pool where cholesterol esterification rate is under the control of HDL, LDL and VLDL subpopulations, and finally the destination of newly produced cholesteryl esters either to the catabolism in liver or to a futile cycle with apoB lipoproteins. The functionality of LCAT substantially depends on its mass together with the composition of the phospholipid bilayer as well as the saturation and the length of fatty acyls and other effectors about which we know yet nothing. Over the years, LCAT puzzle has been significantly supplemented but yet not so satisfactory as to enable how to manipulate LCAT in order to prevent cardiometabolic events. It reminds the butterfly effect when only a moderate change in the process of transformation free cholesterol to cholesteryl esters may cause a crucial turn in the intended target. On the other hand, two biomarkers - FERHDL (fractional esterification rate in HDL) and AIP [log(TG/HDL-C)] can offer a benefit to identify the risk of cardiovascular disease (CVD). They both reflect the rate of cholesterol esterification by LCAT and the composition of lipoprotein subpopulations that controls this rate. In clinical practice, AIP can be calculated from the routine lipid profile with help of AIP calculator www.biomed.cas.cz/fgu/aip/calculator.php., M. Dobiášová., and Obsahuje bibliografii
The library of the Order of St Augustine in the Lesser Town of Prague, comprising more than 18,000 volumes, is an extraordinary book set of significant scientific and historical value. Nevertheless, a scientific study that would cover the entire history of the library was not available until now. This article provides a brief outline of the history of the monastic library at St Thomas, mentioning some remarkable figures that have contributed to its prosperity. The introductory part brings information on the binding rules governing the librarian practice in the monastic libraries of the Order of Saint Augustine in the Middle Ages. Because of the long time span, this treatise has been divided into two parts - the medieval and modern history of the library. Particular attention is paid to two periods - the 14th and 18th centuries, during which some members of the Order held leading positions at the university in Prague and, through their pastoral, preaching and educational activities, they were actively involved in the social, cultural and spiritual edification of broad social classes., Veronika Sladká., Obsahuje anglický abstrakt a shrnutí., and Obsahuje bibliografii
This study focuses on the early modern history of the monastic library of the Order of St Augustine at St Thomas in Prague. On the basis of archival sources (monastic chronicles, the catalogue of the members of the Order) and research into provenances in extant collections, this paper primarily aims to map the development of the Augustinian library in the 16th and 17th centuries. Provenance research has discovered that the monastic library was mainly used for monastic studies and for preaching and pastoral activities of the Augustinians. The research into book provenances has revealed numerous personal ties between the Lesser Town Augustinians and people at the court of Rudolph II. The results of the archival and provenance research have not confirmed the hypothesis of the complete looting of the library at the end of the Thirty Years’ War, but neither have they clearly proved the true extent of the losses suffered by the library. The research has shown the primary role of the library within the Order of St Augustine in the Czech lands and has indicated the position of the library in a broader social and cultural context., Veronika Sladká., and Obsahuje bibliografické odkazy
International Workshop on Astronomical X-Ray-Optics (AXRO) organized by the Institute of Astronomy of the CAS was focused on presentation and discussion of recent and future technologies for future X-ray astronomy missions. One session was aimed on astrophysical aspects of X-ray telescopes/satellites, in which some review talks were given from leading scientists in this field plus some presentations of relevant Czech scientists. The goal of the workshop was to present and to discuss recent and future technologies for X-ray astronomy missions. These missions require development of mostly inovative technologies, and discussed the possibilities, the results obtained so farm and new ideas in detail. It is obvious that the requirements of future large space X-ray optics based on Si wafers, advanced glass forming for precise X-ray optics, but also other possible technologies and alternatives, as well as related advanced metrology, measurements and tests. and Martin Blažek.
Monstrozní, obří, tajemné, vražedné, vymykající se známým fyzikálním zákonům, přímo nepozorovatelné brány do jiných vesmírů... Jen málokteré objekty v kosmu se honosí tak barvitými a rozpruplnými označeními jako černé díry. A současně málokteré tolik dráždí zvědavost nejen veřejnosti, ale také astronomů, kosmologů a (astro)fyziků, kteří se snaží kousek po kousku odrhrnout roušku jejich tajemství. Černé díry se však nehodlají vzdát a vzdorovitě připravují jedno překvapení za druhým. and Jana Olivová, Michal Švanda.
Each cell types or tissues contain certain “physiological” levels of R-2-hydroxyglutarate (2HG), as well as enzymes for its synthesis and degradation. 2HG accumulates in certain tumors, possessing heterozygous point mutations of isocitrate dehydrogenases IDH1 (cytosolic) or IDH2 (mitochondrial) and contributes to strengthening their malignancy by inhibiting 2-oxoglutaratedependent dioxygenases. By blocking histone de-methylation and 5-methyl-cytosine hydroxylation, 2HG maintains cancer cells de-differentiated and promotes their proliferation. However, physiological 2HG formation and formation by non-mutant IDH1/2 in cancer cells were neglected. Consequently, low levels of 2HG might play certain physiological roles. We aimed to elucidate this issue and found that compared to highest 2HG levels in hepatocellular carcinoma HepG2 cells and moderate levels in neuroblastoma SH-SY5Y cells, rat primary fibroblast contained low basal 2HG levels at early passages. These levels increased at late passage and likewise 2HG/2OG ratios dropped without growth factors and enormously increased at hypoxia, reaching levels compared to cancer HepG2 cells. Responses in SH-SY5Y cells were opposite. Moreover, external 2HG supplementation enhanced fibroblast growth. Hence, we conclude that low 2HG levels facilitate cell proliferation in primary fibroblasts, acting via hypoxia-induced factor regulations and epigenetic changes., A. Dvořák, J. Zelenka, K. Smolková, L. Vítek, P. Ježek., and Obsahuje bibliografii
At present, there are insufficient information about baroreflex sensitivity (BRS) and factors that determine BRS in premature newborns. The objective of this study was to determine the relationship between BRS and the characteristics that reflecting the intrauterine development (gestational age and birth weight), as well as postnatal development (postconception age and the actual weight of the child at the time of measurement). We examined 57 premature infants, who were divided into groups according to gestational age and postconception age as well as birth weight, and weight at the time of measurement. Continuous and noninvasive registration of peripheral blood pressure (BP) was perf ormed in every child within 2-5 m in under standard conditions using a Portapres (FMS) device. The results showed a close correlation of baroreflex sensitivity, heart rate and respiratory rate with gestational age, postconception age, birth weight and actual weight at the time of measureme nt premature newborns. An increase in the characteristics (ages and weights) resulted in increased BRS and diastolic arterial pressure (DAP), and in decreased heart and respiratory rates. Baroreflex sensitivity in the first week was in the group of very premature newborns the lowest (4.11 ms/mmHg) and in the light premature newborns was almost double (8.12 ms/mmHg). BRS increases gradually in relation to postnatal (chronological) and to postconception age as well as to birth and actual weight. The multifact or analysis of BRS identified birth weight and postconception age as the best BRS predictors. The two independent variables together explained 40 % of interindividual BRS variability., K. Haskova, M. Javorka, B. Czippelova, M. Zibolen, K. Javorka., and Obsahuje bibliografii