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11172. Úřad moravského zemského hejtmana za posledních Lucemburků (1411-1423)
- Creator:
- Svoboda, Josef
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- moravian land captain, margravate of Moravia, 15th century, and Hussitism in Moravia
- Language:
- Czech, English, and German
- Description:
- This study deals with the changes in position of the office of moravian land captain during the reign of last members of house Luxemburg in Moravia, since the ascension of king Venceslaus IV. in the year 1411, over the reign of Sigismund of Hungary, to the granting of Moravian margravate to Albrecht V. of Habsburg in october 1423. The author corrects some deficiencies of existing literature and specifies the chronology of holders of this office. Based on the analysisi of sources are also reconstructed purviews and areas, in which the land captain could intervene and their changes in time of hussite wars and reign of different margraves. This work also captures the way of appointment and deposition of land captains by the ruler and different strategies and attempts to alternate arrangement of administration of Moravian margravate by Sigismund of Hungary, when he tried to sideline this office, which became more and more dependent on the forming high nobility estate.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
11173. Uric acid levelis positively associated with NT-proBNP concentration in Slovak heart failure patients
- Creator:
- Sabaka, P., Dukat, A., Gajdosik, J., Caprnda, M., Bendzala, M., and Simko, F.
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- uric acid, heart failure, NT-proBNP, confounding factors, and biochemical marker
- Language:
- English
- Description:
- Increased concentration of uric acid (UA) is positively associated with the clinical severity but negatively associated with the prognosis of heart failure (HF). However, data related to the association between UA concentration and N-terminal pro brain natriuretic peptide (NT-proBNP) are still lacking. The aim of the study was to analyze the relationships between UA, NT-proBNP, clearance of creatinine and NYHA function class and echocardiographic variables in the Slovak population of primary care patients diagnosed with HF. The association between UA and NT-proBNP was assessed by multivariate analysis. 848 patients (402 men, 446 women) with HF were included in the study. NT-proBNP correlated with UA in both men and women after adjustment based on age, BMI and glomerular filtration rate (r=0.263, p<0.0001; r=0.293, p<0.0001). UA concentration rose with the severity of the NYHA class and was significantly higher in patients with moderate and severe systolic dysfunctions as well as with diastolic dysfunction in the multivariate analysis. In conclusion, our study in Slovak population with HF has revealed a positive correlation between the concentration of UA and NT-proBNP, and the independency of this association on confounding factors. The results support the role of UA as a biochemical marker of HF severity and prognosis.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
11174. Uridine - an indicator of post-exercise uric acid concentration and blood pressure
- Creator:
- Dudzinska, W., Lubkowska, A., Dolegowska, B., Suska, M., and Janiak, M.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, kyselina močová, krevní tlak, tělesná cvičení, uric acid, blood pressure, exercises, uridine, 14, and 612
- Language:
- English
- Description:
- Studies have shown that uridine concentration in plasma may be an indicator of uric acid production in patients with gout. It has been also postulated that uridine takes part in blood pressure regulation. Since physical exercise is an effective tool in treatment and prevention of cardio-vascular diseases that are often accompanied by hyperuricemia and hypertension, it seemed advisable to attempt to evaluate the relationship between oxypurine concentrations (Hyp, Xan and UA) and that of Urd and BP after physical exercise in healthy subjects. Sixty healthy men (17.2±1.71 years, BMI 23.2±2.31 kg m-2, VO2max 54.7±6.48 ml kg-1 min-1) took part in the study. The subjects performed a single maximal physical exercise on a bicycle ergometer. Blood for analyses was sampled three times: immediately before exercise, immediately after exercise, and in the 30th min of rest. Concentrations of uridine and hypoxanthine, xanthine and uric acid were determined in whole blood using high-performance liquid chromatography. We have shown in this study that the maximal exercise-induced increase of uridine concentration correlates with the post-exercise increase of uric acid concentration and systolic blood pressure. The results of our study show a relationship between uridine concentration in blood and uric acid concentration and blood pressure. We have been the first to demonstrate that a maximal exercise-induced increase in uridine concentration is correlated with the post-exercise and recovery-continued increase of uric acid concentration in healthy subjects. Thus, it appears that uridine may be an indicator of post-exercise hyperuricemia and blood pressure., W. Dudzinska, A. Lubkowska, B. Dolegowska, M. Suska, M. Janiak., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
11175. Urinary urea nitrogen excretion during the hyperinsulinemic euglycemic clamp in type 1 diabetic patients and healthy subjects
- Creator:
- Pavel Wohl, Eva Krušinová, Marta Klementová, Petr Wohl, Simona Kratochvílová, and Terezie Pelikánová
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, diabetologie, inzulín, kalorimetrie, diabetology, insulin, calorimetry, substrate utilization, urinary urea nitrogen excretion, glycemic clamp, indirect calorimetry, 14, and 612
- Language:
- English
- Description:
- The hyperinsulinemic euglycemic clamp (HEC) combined with indirect calorimetry (IC) is used for estimation of insulin-stimulated substrate utilization. Calculations are based on urinary urea nitrogen excretion (UE), which is influenced by correct urine collection. The aims of our study were to improve the timing of urine collection during the clamp and to test the effect of insulin on UE in patients with type 1 diabetes (DM1; n=11) and healthy subjects (C; n=11). Urine samples were collected (a) over 24 h divided into 3-h periods and (b) before and during two-step clamp (1 and 10 mIU.kg-1.min-1; period 1 and period 2) combined with IC. The UE during the clamp was corrected for changes in urea pool size (UEc). There were no significant differences in 24-h UE between C and DM1 and no circadian variation in UE in either group. During the clamp, serum urea decreased significantly in both groups (p<0.01). Therefore, UEc was significantly lower as compared to UE not adjusted for changes in urea pool size both in C (p<0.001) and DM1 (p<0.001). While UE did not change during the clamp, UEc decreased significantly in both groups (p<0.01). UEc during the clamp was significantly higher in DM1 compared to C both in period 1 (p<0.05) and period 2 (p<0.01). The UE over 24 h and UEc during the clamp were statistically different in both C and DM1. We conclude that urine collection performed during the clamp with UE adjusted for changes in urea pool size is the most suitable technique for measuring substrate utilization during the clamp both in DM1 and C. Urine collections during the clamp cannot be replaced either by 24-h sampling (periods I-VII) or by a single 24-h urine collection. Attenuated insulin-induced decrease in UEc in DM1 implicates the impaired insulin effect on proteolysis. and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
11176. Urine composition in pigs is regulated in both the ureter and the bladder
- Creator:
- Kaasgaard Jakobsen, L., Andersson, K.-E., Nørregaard, R., and Henning Olsen , L.
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- urine composition and animal model
- Language:
- English
- Description:
- The former perception of the urothelium as an impermeable barrier has been revised during the last decade, as increasing evidence of changes in urine composition during its passage of the urinary tract has been presented. Since differences in urothelial permeability between upper and lower urinary tract have been found, our aim is to demonstrate whether changes in urine composition occur during passage through the ureter. We studied consecutive urine samples from both renal pelvises in six pigs and compared them to samples from the bladder and distal ureter. We further sampled urine during storage in the bladder at a fixed volume. All samples were analysed by measuring osmolality and pH, along with the concentration of the following parameters: Na+, K+, Cl- , creatinine, urea. Urine alkalinity increased significantly during passage of the ureter. Creatinine concentration, pH and K+ increased significantly during the passage from pelvis to the bladder. All other parameters increased non-significantly during the passage to the bladder. The increase in concentration was more pronounced at low concentrations in the pelvis. During storage in the bladder, there was a significant increase in urea concentration. Changes in the composition of urine occur during its passage from the renal pelvis to the bladder and during storage in the bladder. Despite the brief transit time, significant changes in alkalinity were found already during passage through the ureter.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
11177. Urine sample used for detection of Toxoplasma gondii infection by loop-mediated isothermal amplification (LAMP)
- Creator:
- Hu, Xin, Pan, Chang-Wang, Li, Ya-Fei, Wang, Han, and Tan, Feng
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- Toxoplasma gondii, toxoplasmosis, loop-mediated isothermal amplification (LAMP), urine, B1, and mouse
- Language:
- English
- Description:
- In this study, a loop-mediated isothermal amplification (LAMP) assay was established to detect Toxoplasma gondii DNA in mice infected with T. gondii PRU strain. This LAMP assay was based on the sequence of highly repetitive B1 gene. The detection limit of T. gondii LAMP assay was 1 pg of T. gondii DNA, which was evaluated using 10-fold serially diluted DNA of cultured parasites. The LAMP assay was also highly specific for T. gondii and able to detect T. gondii DNA in urine of mice treated with dexamethasone at 90 day post infection (p.i.), although this assay could not detect the DNA in mice urine 2-6 days p.i. These results demonstrated that LAMP is effective for evaluation of therapy effectiveness for T. gondii infection. The established LAMP assay may represent a useful and practical tool for the routine diagnosis and therapeutic evaluation of human toxoplasmosis.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
11178. Urysohn’s lemma, gluing lemma and contraction∗ mapping theorem for fuzzy metric spaces
- Creator:
- Roja, Elango, Uma, Mallasamudram Kuppusamy, and Balasubramanian, Ganesan
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- fuzzy contraction mapping and fuzzy continuous mapping
- Language:
- English
- Description:
- In this paper the concept of a fuzzy contraction∗ mapping on a fuzzy metric space is introduced and it is proved that every fuzzy contraction∗ mapping on a complete fuzzy metric space has a unique fixed point.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
11179. Use of 3D geometry modeling of osteochondrosis-like iatrogenic lesions as a template for press-and-fit scaffold seeded with mesenchymal stem cells
- Creator:
- Petr Krupa, Pavel Kršek, Javorník, M., Otto Dostál, Robert Srnec, Dušan Usvald, Pavel Proks, Helga Kecová, Evžen Amler, Josef Jančář, Peter Gál, Ladislav Plánka, and Alois Nečas
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, chrupavka, mezenchymální kmenové buňky, cartilage, mesenchymal stem cells, CT imaging, tissue segmentation, joint resurfacing, miniature pig, 14, and 612
- Language:
- English
- Description:
- Computed tomography (CT) is an effective diagnostic modality for three-dimensional imaging of bone structures, including the geometry of their defects. The aim of the study was to create and optimize 3D geometrical and real plastic models of the distal femoral component of the knee with joint surface defects. Input data included CT images of stifle joints in twenty miniature pigs with iatrogenic osteochondrosis-like lesions in medial femoral condyle of the left knee. The animals were examined eight and sixteen weeks after surgery. Philips MX 8000 MX and View workstation were used for scanning parallel plane cross section slices and Cartesian discrete volume creation. On the average, 100 slices were performed in each stifle joint. Slice matrices size was 512 x 512 with slice thickness of 1 mm. Pixel (voxel) size in the slice plane was 0.5 mm (with average accuracy of ± 0.5 mm and typical volume size 512 × 512 × 100 voxels). Three-dimensional processing of CT data and 3D geometrical modelling, using interactive computer graphic system MediTools formerly developed here, consisted of tissue segmentation (raster based method combination and 5 % of manual correction), vectorization by the marching-cubes method, smoothing and decimation. Stifle- joint CT images of three individuals of different body size (small, medium and large) were selected to make the real plastic models of their distal femurs from plaster composite using rapid prototyping technology of Zcorporation. Accuracy of the modeling was ± 0.5 mm. The real plastic models of distal femurs can be used as a template for developing custom made press and fit scaffold implants seeded with mesenchymal stem cells that might be subsequently implanted into iatrogenic joint surface defects for articular cartilage-repair enhancement., P. Krupa, P. Kršek, M. Javorník, O. Dostál, R. Srnec, D. Usvald, P. Proks, H. Kecová, E. Amler, J. Jančář, P. Gál, L. Plánka, A. Nečas., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
11180. Use of a right ventricular continuous flow pump to validate the distensible model of the pulmonary vasculature
- Creator:
- Vanden Eynden, F. , Segers, P., Bové, T. , De Somer, F., El Oumeiri, B., and Van Nooten, G.
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- Pulmonary circulation, Distensibility, Assist device, and Vascular resistence
- Language:
- English
- Description:
- In the pulmonary circulation, resistive and compliant properties overlap in the same vessels. Resistance varies nonlinearly with pressure and flow; this relationship is driven by the elastic properties of the vessels. Linehan et al. (1982) correlated the mean pulmonary arterial pressure and mean flow with resistance using an original equation incorporating the distensibility of the pulmonary arteries. The goal of this study was to validate this equation in an in vivo porcine model. In vivo measurements were acquired in 6 pigs. The distensibility coefficient (DC) was measured by placing piezo-electric crystals around the pulmonary artery (PA). In addition to experiments under pulsatile conditions, a right ventricular (RV) bypass system was used to induce a continuous pulmonary flow state. The Linehan's equation was then used to predict the pressure from the flow under continuous flow conditions. The diameter-derived DC was 2.4 %/mmHg (±0.4 %), whereas the surface area-based DC was 4.1 %/mmHg (±0.1 %). An increase in continuous flow was associated with a constant decrease in resistance, which correlated with the diameter-based DC (r=-0.8407, p=0.044) and the surface areabased DC (r=-0.8986, p=0.028). In contrast to the Linehan’s equation, our results showed constant or even decreasing pressure as flow increased. Using a model of continuous pulmonary flow induced by an RV assist system, pulmonary pressure could not be predicted based on the flow using the Linehan’s equation. Measurements of distensibility based on the diameter of the PA were inversely correlated with the resistance.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public