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8882. ScreenPro FH: from the Czech MedPed to international collaboration. ScreenPro FH is a participating project of the EAS-FHCS
- Creator:
- Richard Češka, Tomáš Freiberger, Martina Vaclová, Aleksicova, T., Votavova, L., and Michal Vrablík
- Format:
- print, bez média, and svazek
- Type:
- article, články, journal articles, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, familiární hypercholesterolémie, familial hypercholesterolemia, MedPed, screenPro FH, FHSC, statin intolerance, 14, and 612
- Language:
- English
- Description:
- This article describes the evolution of our understanding of familial hypercholesterolemia (FH) in the Central, Eastern, and Southern Europe (CESE) region, and the dissemination of this understanding to other count ries. Using the ScreenPro FH project as an example, we would like to illustrate the progression from national objectives, to regional networking and, finally, to international collaboration via the Familial Hypercholesterolemia Studies Collaboration (FHSC) project under the leadership of the European Atherosclerosis Society (EAS). It is essential to improve our ability to diagnose FH. In this regard, the EAS and its FHSC project must be commended for their educational and organizational activities which, ab ove all, are dedicated to the creation of a global FH patient registry. In the CESE region, FH diagnostics and treatment situation are markedly different than in Western Europe or North America. Since the Czech MedPed project (Make Early Diagnoses to Preve nt Early Deaths in Medical Pedigrees) has been so successful (with results not only comparable to, but, for some parameters, even surpassing the results of many Western countries) we decided to apply the Czech experience to the CESE region. Thus, the ScreenPro FH project was created. The aim of ScreenPro FH is to create a specialist network in the CESE region. The primary objective of the ScreenPro FH project was to dramatically reduce the number of premature deaths due to clinical complications of atherosc lerosis in FH patients. At present, ScreenPro FH comprises 18 member countries with a total population of 500,000,000; which, in terms of the FH population, represents 1-2 million patients., R. Ceska, T. Freiberger, M. Vaclova, T. Aleksicova, L. Votavova, M. Vrablik., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
8883. SEA0400, a novel Na+/Ca2+ exchanger inhibitor, reduces calcium overload induced by ischemia and reperfusion in mouse ventricular myocytes
- Creator:
- Wang, J., Zhang, Z., Yuehua Hu, Hou, X., Cui, Q., Zang, Y., and Wang, Chen
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, ischemie, human physiology, ischemia, SEA0400, patch clamp, Na+/Ca2+ exchanger current, 14, and 612
- Language:
- English
- Description:
- Given the potential clinical benefit of inhibiting Na+/Ca2+ exchanger (NCX) activity dur ing myocardial ischemia reperfusion (I/R), pharmacological approaches have been pursued to both inhibit and clarify the importance of this exchanger. SEA0400 was reported to have a potent NCX selectivity. Thus, we examined the effect of SEA0400 on NCX currents and I/R induced intracellular Ca2+ overload in mouse ventricular myocytes using patch clamp techniques and fluorescence measurements. Ischemia significantly inhibited inward and outward NCX current (from -0.04±0.01nA to 0 nA at -100 mV; from 0.23±0.08 nA to 0.11±0.03 nA at +50 mV, n=7). Subsequent reperfusion not only restored the current rapidly but enhanced the current amplitude obviously, especially the outward currents (from 0.23±0.08 nA to 0.49±0.12 nA at +50 mV, n=7). [Ca2+]i, expressed as the ratio of Fura-2 fluorescence intensity, increased to 138±7 % (P<0.01) during ischemia and to 210±11 % (P<0.01) after reperfusion. The change of NCX current and the increase of [Ca 2+]i during I/R can be blocked by SEA0400 in a dose-dependent manner with an EC50 value of 31 nM and 28 nM for the inward and outward NCX current, respectively. The results suggested that SEA0400 is a potent NCX inhibitor, which can protect mouse cardiac myocytes from Ca2+ overload during I/R injuries., J. Wang, Z. Zhang, Y. Hu, X. Hou, Q. Cui, Y. Zang, C. Wang., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
8884. Seasonal scarcity and sharing norms
- Creator:
- Bartoš, Vojtěch
- Publisher:
- CERGE-EI
- Format:
- electronic, bez média, svazek, and 53 stran : ilustrace.
- Type:
- model:monograph and TEXT
- Subject:
- Ekonomie, experimentální ekonomie, venkov, chudoba, experimental economics, countryside, poverty, Afghánistán, Afghanistan, 33-028.77, 316.334.55, 364.662, (581), (048.8), 4, and 33
- Language:
- English and Czech
- Description:
- Vojtěch Bartoš., Obsahuje bibliografii a bibliografické odkazy, and České a anglické resumé
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
8885. Seasonal stability in parasite assemblages of the Brazilian flathead, Percophis brasiliensis (Perciformes: Percophidae): predictable tools for stock identification
- Creator:
- Braicovich, Paola E. and Timi, Juan T.
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- parasite communities, temporal stability, biological tags, fish populations, and south-west Atlantic
- Language:
- English
- Description:
- A comparison of the composition and structure of parasite communities of the Brazilian flathead, Percophis brasiliensis Quoy et Gaimard (Perciformes: Percophidae) among seasons during one year was carried out in the Argentine Sea. A total of 195 fish specimens were examined and 25 parasite species were found. Parasite communities in seasonal samples showed a high degree of homogeneity in taxonomic composition and infection levels. Similarity analysis showed that the seasonal stability within and between samples was constant in both the composition and community structure throughout the year. Parasites can, therefore, be considered predictable markers for fish stock identification, independently of the season of capture, at least on an annual scale.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
8886. Seasonal variations in properties of healthy and diabetic rat heart mitochondria: Mg2+-ATPase activity, content of conjugated dienes and membrane fluidity
- Creator:
- Jana Mujkošová, Miroslav Ferko, Humeník, P., Waczulíková, I., and Atila Ziegelhöffer
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Experimentální medicína, kardiovaskulární fyziologie, mitochondrie, srdce, dieny, cardiovascular physiology, mitochondrias, heart, diens, seasonal variations, mitochondrial Mg2+-ATPase, membrane fluidity, diabetic heart, 14, and 616-092
- Language:
- English
- Description:
- Our previous preliminary results pointed to possible seasonal variations in Mg2+-ATPase activity of rat heart mitochondria (MIT). It is not too surprising since seasonal differences were already reported in myocardial function, metabolism and ultrastructure of the intact as well as hemodynamically overloaded rabbit hearts and also in other tissues. The present study is aimed to elucidate whether seasonal differences observed in rat heart MIT Mg2+-ATPase activity will be accompanied with changes in membrane fluidity and in the content of conjugated dienes (CD) in the lipid bilayers of MIT membranes as well as whether the above seasonal differences will also be present in the diabetic heart. Our results revealed that values of Mg2+-ATPase activity in the winter/spring-period (W/S-P) exceeded significantly (p<0.05-0.001) those in the summer/autumn-period (S/A-P). Similar trend was also observed in hearts of animals with acute (8 days) streptozotocin diabetes. With the exception of values of CD in the S/A-P, all values of Mg2+-ATPase activities, membrane fluidity and CD concentrations in diabetic hearts exceeded those observed in the healthy hearts. Our results indicate that seasonal differences may play a decisive role in the evaluation of properties and function of rat heart MIT., J. Mujkošová, M. Ferko, P. Humeník, I. Waczulíková, A. Ziegelhöffer., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
8887. Seasonal variations of gonadotropins and prolactin in the laboratory rat. Role of maternal pineal gland
- Creator:
- Vázquez, N., Díaz, E., Fernández, C., Jiménez, V., Esquifino, A., and Díaz, Beatrice López
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, hormony hypofýzy, laboratorní zvířata, physiology, pituitary hormones, laboratory animals, gonadotropiny, prolaktin, maternal pineal gland, seasonal variations, gonadotropins, prolactin, 14, and 612
- Language:
- English
- Description:
- The laboratory rat, a non-photoperiodic rodent, exhibits seasonal fluctuations of melatonin. Melatonin has been found to be readily transferred from the maternal to the fetal circulation. No data exist on the possible influence of maternal pineal gland upon seasonal variations of the offspring. The aim of the present study was to asses the influence of the maternal melatonin rhythm on the offspring postnatal development of the reproductive hormones LH, FSH and prolactin. Male offspring from control, pinealectomized (PIN-X) and PIN-X + melatonin (PIN-X+MEL) mother Wistar rats were studied at 21, 31, and 60 days of age. Seasonal age-dependent variations were found for all hormones studied in control offspring but PIN-X offspring showed a tendency to have reduced duration or altered seasonal variations. Maternal melatonin treatment to PIN-X mothers partially restored the effect of pinealectomy. The chronological study of LH, FSH, and prolactin in PIN-X offspring also showed an altered pattern as compared to control-offspring. Melatonin treatment to the mothers partially restored the developmental pattern of reproductive hormones. Results of this study indicate that maternal pineal gland of the laboratory rat is involved in the seasonal postnatal development variations of reproductive hormones of the offspring., N. Vásquez, E. Díaz, C. Fernández, V. Jiménez, A. Esquifino, B. Díaz., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
8888. Second centralizers of partial transformations
- Creator:
- Konieczny, Janusz
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- partial transformation and second centralizer
- Language:
- English
- Description:
- Second centralizers of partial transformations on a finite set are determined. In particular, it is shown that the second centralizer of any partial transformation $\alpha $ consists of partial transformations that are locally powers of $\alpha $.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
8889. Second generation of conical strain gauge probe for stress measurement in rock massif
- Creator:
- Jaromír Knejzlík, Rambouský, Zdeněk, Kamil Souček, and Staš, Lubomír
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Geologie. Meteorologie. Klimatologie, geodynamika, geodynamics, stress measurement, over-coring, 7, and 551
- Language:
- English
- Description:
- Compact conical strain gauge probe for borehole over-coring rock massif stress measurement (CCBO), based on experiences of K. Sugavara and Y. Obara, has been developed in Institute of Geonics ASCR, v.v.i. from 2004. First generation of CCBO is equipped by simple electronic circuit which requires continuous communication with control computer in the course of measurement. Prototypes of this type probes are used for long term stress changes monitoring induced by longwall advancement in mine. Solving of continuous data communication through rotating drilling tool filled by wash water in course of over-coring is very difficult technical task, which is not possible to solve in terms of grant project. To avoid this problem a development of second generation of CCBO equipped by microprocessor and internal data logger was initialised. Simplified modification of CCBO is developed as a probe for long-term monitoring of rock massif stress changes (Compact Conical Ended Borehole Monitoring - CCBM). Design of both models probes, discussion of measurement errors and technique of sensitivity self-calibration is described., Jaromír Knejzlík, Zdeněk Rambouský, Kamil Souček and Lubomír Staš., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
8890. Second moments of Dirichlet $L$-functions weighted by Kloosterman sums
- Creator:
- Wang, Tingting
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- general $k$-th Kloosterman sum, Dirichlet $L$-function, the mean square value, and asymptotic formula
- Language:
- English
- Description:
- For the general modulo $q\geq 3$ and a general multiplicative character $\chi $ modulo $q$, the upper bound estimate of $ |S(m, n, 1, \chi , q)| $ is a very complex and difficult problem. In most cases, the Weil type bound for $ |S(m, n, 1, \chi , q)| $ is valid, but there are some counterexamples. Although the value distribution of $ |S(m, n, 1, \chi , q)| $ is very complicated, it also exhibits many good distribution properties in some number theory problems. The main purpose of this paper is using the estimate for $k$-th Kloosterman sums and analytic method to study the asymptotic properties of the mean square value of Dirichlet $L$-functions weighted by Kloosterman sums, and give an interesting mean value formula for it, which extends the result in reference of W. Zhang, Y. Yi, X. He: On the $2k$-th power mean of Dirichlet L-functions with the weight of general Kloosterman sums, Journal of Number Theory, 84 (2000), 199–213.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public