Metabotropic glutamate receptors (mGluRs) represent a potential therapeutic target. Possible anticonvulsant action of AMN 082, an agonist of mGluR7 subtype, was studied in immature rats using pentylenetetrazol (PTZ)-induced seizures as a model. Five age groups of rats (7-, 12-, 18-, 25-day-old and adult animals) were pretreated with AMN 082 in doses of 0.5, 1, 2, and 5 mg/kg i.p. and 30 min later PTZ was administered (100 mg/kg s.c.). Controls received saline instead of the agonist. AMN 082 did not exhibit clear anticonvulsant action with the exception of suppression of the tonic phase of generalized tonic-clonic seizures (GTCS) in 12-day-old rats. Shorter latencies of GTCS after AMN 082 pretreatment indicate a proconvulsant action. Involuntary movements (mostly tremor) appeared after AMN 082 before PTZ administration, therefore we performed another experimental series with AMN 082 only (1, 2, 5, and 10 mg/kg i.p.). During 60-min observation period tremor appeared in all age groups; sensitivity to this action decreased with age from the 2 mg/kg dose in 7- and 12-day-old rats to the 10 mg/kg dose in adult rats. Mixed anti- and proconvulsant actions of AMN 082 together with unwanted motor effects makes clinical use of this drug highly improbable., Pavel Mareš., and Obsahuje bibliografii a bibliografické odkazy
This paper explores the notion of “power” prevalent in Václav Havel’s understanding of the post-totalitarian regime. With this notion of power, which is “seeping” in nature, rather than rooted solely in an individual agent’s actions, the role of the individual in the formation of the political “we” becomes a central issue. The starting point is Havel’s well-known example of “the greengrocer,” that illustrate how Havel pictures the way out of the post-totalitarian regime as one in which individuals move from living a lie to living in truth. I show how Havel’s talk about truth and authenticity, and his emphasis on a life in truth (which may appear judgemental, naive and cliché-like) is best understood. The wrong way to understand this is simply to say that people who merely obeyed that government, as the greengrocer did, are to be held accountable because they did not put up a fight against their oppressor. Such an understanding goes wrong because it fails to take into account the complexity of the relationship between power and language. In contrast to this, I argue that the central issue here is not that particular agents are to be held responsible for countersigning messages that they think are false. More precisely, I argue that the moral difficulty here is that the greengrocer’s deeds, which appear as countersignatures of the regime, are possible because the messages conveyed are “innocent” on the surface, in a “literal” sense. The moral dimension of the greengrocer’s actions, aiming to shed light on the complex relation between the government and the individual, is revealed as located in a field of tension between inherited sense and new projections. This, in turn, can help us to see the real nature of the transition Havel’s grocer undergoes when he moves from living a lie to living in truth. It is not a matter of negating a false statement or utterance, nor of replacing it with a true one. It is a matter of realising that the responsibility for meaning is, ultimately, ours – and that the way in which he, the grocer, is one of us is something that has to be earned.
The object of the research was to investigate the spectral properties of Rayleigh-type surface waves, generated by shot-hole explosions during seismic refraction experiments which were carried out in the area of the Bohemian Massif and West Carpathians. The records of displacement amplitudes were spectrally analyzed and prevailing frequency fp, relative Δfr and absolute widths of the spectra Δfa were chosen as essential parameters. Whilst the prevailing frequencies were recorded within the interval f ÷ 0.80 - 3.70 Hz at the site of the observations, situated on the territory of the Bohemian Massif, the respecti ve frequency range f ÷ 0.80 - 2.6 Hz was found in the West Carpathians. Some functional dependences of the spectral amplitude parameters on epicentral distance were observed and regularities of their decrease were defined. Moreover, the influence of local seismogeological conditions at the shot point as well as at the site of observation occurred., Karel Holub., and Obsahuje bibliografické odkazy