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2102. Anthropogenic impact on selected oxbow lakes in the Elbe River floodplain
- Creator:
- Chalupová, Dagmar and Janský, Bohumír
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- oxbow lake, Elbe, flood, water quality, pollution, plankton, heavy metals, sediment, slepé rameno, Labe, povodeň, kvalita vody, znečištění, and těžké kovy
- Language:
- Slovak
- Description:
- From the year 2000, the environmental state and the impact of human activities on fluvial lakes in the central part of the Czech section of the Elbe River is evaluated. For that reason, three oxbow lakes were chosen: Lake Labiště pod Opočínkem (east of Pardubice), Lake Doleháj (near Kolín), and Lake Obříství (near Mělník). All of them are situated within an area with a well-developed chemical industry and the nearby lowlands are one of the most intensively farmed areas of the Czech Republic. In spite of the identical origin during the river canalization, major differences were found. E.g. very low oxygen saturation in Opočínek (mean saturation 46 %) was determined. Nutrient concentrations and their seasonal dynamics (nitrites, nitrates, ammoniated ions, and phosphates) differed in each lake as well. The lowest concentrations of heavy metals (Ag, Cd, Co, Cr, Cu, Fe, Hg, Mn, Ni, Pb and Zn) in sediment were found in the Doleháj. In samples from Obříství after a big flood in September 2002, the Index of Geoaccumulation increased only for Pb and decreased for Hg. This result indicated that the pollution has probably not been occurred during such floods. and Od roku 2000 jsou v oblasti středního Labe hodnoceny přírodní podmínky starých labských ramen a posuzován vliv antropogenní činnosti na ně. Z toho důvodu byly pro výzkum vybrány následující tři slepé opuštěné meandry: Labiště pod Opočínkem (východně od Pardubic), Doleháj (v blízkosti Kolína) a jezero Obříství (v blízkosti Mělníka). Všechna tato fluviální jezera leží v oblasti s velmi rozvinutým chemickým průmyslem, přilehlé nížiny jsou též jedny z nejintenzivněji obdělávaných zemědělských ploch v České republice. Ačkoliv jezera vznikla stejným způsobem při regulacích řeky, byly mezi nimi zjištěny značné rozdíly. Například lokalita Opočínek vykazovala značně nízké hodnoty nasycení vody kyslíkem (průměrné nasycení 46 %). Koncentrace živin a jejich sezónní dynamika (dusitany, dusičnany, amonné ionty a fosforečnany) se též v každém případě lišila. Nejnižší koncentrace těžkých kovů (Ag, Cd, Co, Cr, Cu, Fe, Hg, Mn, Ni, Pb a Zn) v sedimentu byly zaznamenány v Doleháji. Ve vzorcích z lokality Obříství po velké povodni v roce 2002 se zvýšil geoakumulační index jen v případě Pb, naopak hodnota u Hg poklesla. Výsledky proukázaly nepřítomnost výrazného znečištění po této povodni.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
2103. Anti-CD38 therapy with daratumumab for relapsed/refractory CD20-negative diffuse large B-Cell lymphoma
- Creator:
- Vockova, P. , Svaton, M. , Karolova, J. , Pokorna, E., Vokurka, M., and Klener, P.
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- Non-Hodgkin lymphomas, CD38, daratumumab, and patient-derived xenograft
- Language:
- English
- Description:
- Diffuse large B-cell lymphoma (DLBCL) is the most common and one of the most aggressive subtypes of non-Hodgkin’s lymphomas. Front-line therapy consists of chemotherapy in combination with anti-CD20 monoclonal antibody rituximab. Relapses after rituximab-based regimen have poor prognosis and call for new treatment options. Immunohistochemistry analysis of relapsed DLBCL often reveal CD20-negative lymphoma, which limits repeated use of rituximab in combination with salvage chemotherapy. CD38 is a surface antigen that binds to CD38, CD31/PECAM-1 and hyaluronic acid. CD38 is an important mediator of signal transmission from the microenvironment into the cell. Anti-CD38 monoclonal antibody daratumumab has been approved for the treatment of multiple myeloma. Expression of CD38 on the surface of DLBCL is highly variable (compared to strong expression on myeloma cells), but can be easily assessed by flow cytometry or immunohistochemistry. A patient-derived xenograft (PDX) model of CD20-negative, CD38-positive DLBCL derived from a patient with rituximab-refractory DLBCL was used for in vivo experiments. We demonstrated that daratumumab suppressed growth of subcutaneous PDX tumours significantly more effectively than rituximab. Analysis of tumours obtained from mice treated with daratumumab revealed down-regulation of surface CD38, suggesting endocytosis of CD38-daratumumab complexes. The results suggest a potential clinical use of daratumumab in combination with salvage chemotherapy in patients with relapses of CD20-negative DLBCL. In addition, daratumumab might potentially serve as a suitable antibody moiety for derivation of antibodydrug conjugates for the targeted delivery of toxic payloads to the lymphoma cells.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2104. Anti-Helicobacter pylori, anti-thyroid peroxidase, anti-thyroglobulin and anti-gastric parietal cells antibodies in Czech population
- Creator:
- Ivan Šterzl, Pavlína Hrdá, Petr Matucha, Jarmila Čeřovská, and Václav Zamrazil
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, endokrinologie, Helicobacter pylori, protilátky, endocrinology, antibodies, thyroid peroxidase, thyroglobulin, gastric parietal cells, 14, and 612
- Language:
- English
- Description:
- Autoimmune thyropathies are frequently linked to many infections, such as Helicobacter pylori, which are also supposed to play a role in their pathogenesis. The aim of this study was to evaluate the relationships between thyroid and gastric autoimmunity and H. pylori infection on a large sample of Czech population (n=1621) by monitoring the autoantibodies against thyroglobulin (anti-Tg) and thyroid peroxidase (anti-TPO) and gastric parietal cell (anti-GPC, representing thyrogastric syndrome) in correlation with antibodies against Helicobacter pylori (anti-H. pylori) of classes IgG and IgA. The interrelation between autoantibodies and H. pylori antibodies was assessed by H. pylori seropositivity. In H. pylori seropositive persons as compared to seronegative irrespective of age and sex, a higher occurrence of anti-TPO (10.4 % vs. 5.8 %, p=0.001) and anti-GPC (6.1 % vs. 1.7 %, p<0.001) was found. Differences in anti-TPO occurrence were significant in both men (7.0 % vs. 3.3 %, p=0.03) and women (12.7 % vs. 8.0 %, p=0.02), differences in anti-GPC occurrence were significant only in women (7.2 % vs. 1.7 %, p<0.001). Results of this study support the idea of a connection between infection of H. pylori and the occurrence of anti-TPO autoantibodies representing thyroid autoimmunity and gastric parietal cells autoantibodies representing the thyrogastric syndrome., I. Šterzl, P. Hrdá, P. Matucha, J. Čeřovská, V. Zamrazil., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
2105. Anti-oxidative effect of elevated CO2 concentration in the air on maize hybrids subjected to severe chill
- Creator:
- Bączek-Kwinta, R. and Kościelniak, J.
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- ascorbate peroxidase, catalase, photoinhibition, photosynthetic induction, membrane injury, superoxide dismutase, and Zea mays
- Language:
- Multiple languages
- Description:
- Elevated CO2 concentration (700 cm3 m-3, EC) inhibited chill-dependent (7 °C) depression of net photosynthetic rate of two maize hybrids with different sensitivity to low temperature. The rate of superoxide radical formation in leaves, leaf membrane injury, and the decrease in maximal quantum efficiency of photosystem 2 were successfully diminished by the treatment. The protective effect of EC toward stress conditions was prolonged at the recovery phase (20 °C). The genotypic impact on studied parameters was also notable. and R. Bączek-Kwinta, J. Kościelniak.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
2106. Anti-rómsky bilbord: analýza obrazu a médií
- Creator:
- Jana Plichtová and Paholíková, Vlasta
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Psychologie, psychologie, rasismus, stereotypy, racism, stereotypes, kritická systemická lingvistika, kritická diskurzívna analýza, anti-rómsky populizmus, dehonestácia, stigmatizácia, critical systemic linguistics, critical discursive analysis, anti-Roma populism, dehonestation, stigmatization, 17, and 159.9
- Language:
- Czech
- Description:
- Štúdia sa kriticky zaoberá diskurzívnymi aktivitami politikov a novinárov, ktorí slúžia ako modely pre imitáciu potvrdzovania, alebo naopak oponovania negatívnym stereotypom voči Rómom. Empiricky overuje tézu, že mediálny marketing politických strán zneužíva diskriminované a marginalizované skupiny na dosahovanie straníckych cieľov. Prostredníctvom kritickej systemickej lingvistiky analyzuje významové štruktúry predvolebného bilbordu, čím odhaľuje intencie komunikácie politickej strany s verejnosťou. Postupmi kritickej diskurzívnej analýzy mediálnych textov o anti-rómskom bilborde autorky identifikujú diskurzívne pozície rozmanitých aktérov, prípadne ich argumentačné stratégie, pričom kriticky reflektujú najmä asymetriu ich mediálnej prezentácie. Popisujú Diskuze / 401 sa spôsoby, akými parlamentná strana SNS implicitne (prostredníctvom bilbordu) a explicitne (vo svojich vyjadreniach) znevažuje celú etnickú skupinu. Z analýzy vyplýva, že hoci médiá uvádzajú názory rôznych diskurzívnych aktérov, v textoch chýba prezentácia argumentov, ktoré by pomohli širokej verejnosti pochopiť, prečo dehonestácia tejto stigmatizovanej skupiny je neprijateľná. Politické zneužívanie „rómskeho problému“ novinári demaskovali, avšak nevysvetlili negatívne dôsledky falošnej etnizácie nezamestnanosti, chudoby a verejnej dehonestácie Rómov., The study deals critically with discursive activities of politics and newspapermen which serve as models for imitation of confirmation or on the contrary of opposing the negative stereotypes against Roma. The thesis that the media marketing of political parties misuses the discriminated and marginalized groups for achieving the party goals is empirically verified. The meaning structures of pre-election billboard are analyzed by the means of critical systemic linguistics and thus reveals the intentions of communication of political party with the public. The authors identify the discursive positions of diverse participants, alternatively their argumentation strategies, and critically reflect especially the asymmetry of their media presentation by procedures of critical discursive analysis of media texts about the anti-Roma billboard. The ways how the parliament party SNS implicitly (through the billboard) and explicitly (in its statements) discredit the whole ethnic group are described. From the analysis follows that although media present the opinions of different discourse participants, the texts are lacking the presentation of arguments that could help the wide public to understand why the dehonestation of this stigmatized group is unacceptable. The political misuse of „Roma problem“ was unmasked by newspapermen but the negative consequences of false ethnic attribution of unemployment, poverty, and public dehonestation of Roma were not explained., Jana Plichtová, Vlasta Paholíková., and Obsahuje seznam literatury
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2107. Anti-social behavior in groups
- Creator:
- Bauer, Michal, Cahlíková, Jana, Celik Katreniak, Dagmara, Chytilová, Julie, Cingl, Lubomír, and Želinský, Tomáš
- Publisher:
- CERGE-EI
- Format:
- electronic, bez média, svazek, and 51 stran : ilustrace, tabulky, mapy.
- Type:
- model:monograph and TEXT
- Subject:
- Ekonomie, skupinové chování, rozhodování, experimentální ekonomie, group behavior, decision making, experimental economics, 316.454.3, 005.311.6, 33-028.77, (048.8), 4, and 33
- Language:
- English and Czech
- Description:
- Michal Bauer, Jana Cahlíková, Dagmara Celik Katreniak, Julie Chytilová, Lubomír Cingl, and Tomáš Želinský., Obsahuje bibliografii a bibliografické odkazy, and České a anglické resumé
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
2108. Anti-spurious-state neural network using nonlinear outer product and dynamic synapses
- Creator:
- XIa, M., Shen, M., Wang, J., Weng, L., and Yan , C.
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- associative memory, spurious state, nonlinear function constitution, and dynamic synapse
- Language:
- English
- Description:
- Associative memory (AM) is a very important part of the theory of neural networks. Although the Hebbian learning rule is always used to model the associative memory, it easily leads to spurious state because of the linear outer product method. In this work, nonlinear function constitution and dynamic synapses, against a spurious state for associative memory neural network are proposed. The model of the dynamic connection weight and the updating scheme of the states of neurons are presented. Nonlinear function constitution improves the conventional Hebbian learning rule to be a nonlinear outer product method. The simulation results show that both nonlinear function constitution and dynamic synapses can effectively enlarge the attractive basin. Comparing to the existing memory models, associative memory of neural network with nonlinear function constitution can both enlarge the attractive basin and increase the storage capacity. Owing to dynamic synapses, the attractive basin of the stored patterns is further enlarged, at the same time the attractive basin of the spurious state is diminished. But the storage capacity is decreased by using the dynamic synapses.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2109. Anti-suit injunctions in arbitral and judicial procedures in the Czech Republic
- Creator:
- Alexander J Bělohlávek
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- Česko., ordre public, rozhodčí smlouvy, ústavní právo, jurisdikce, překážka věci pravomocně rozhodnuté, arbitration agreements, constitutional law, jurisdiction, res judicata, anti-suit injunctions, anti-arbitration injunctions, recognition and enforcement of judgements, recognition and enforcement of arbitral awards, arbitration, Charter of Fundamental Rights, Kompetenz-Kompezenz, Lis Pendens, procedural conditions, objective arbitrability, 16, and 34
- Language:
- English
- Description:
- Anti-suit injunctions are rather unknown in the civil law legal system of the Czech Repbulic. The policy reasons for the rejection of anti-suit injunctions in the Czech Republic are rooted in the constitutional right of every person to assert, through the legally prescribed procedure, their rights before an independent and impartial court or, in specified cases, before another body. In other words, every person may commence proceedings before a competent court, or respectively before any court or another body (e.g. like an arbitral tribunal, etc.), which is then exclusively empowered to rule on its jurisdiction. Therefore, there is also no distinction between anti-suit injunctions in domestic and international litigation. Czech law does not have any alternative procedural or substantive devices that may have similar functions as anti-suit injunctions related to arbitration. It means that it is not possible to obtain a court order against a respondent prohibiting the respondent from commencing or continuing court proceedings in another forum in violation of an arbitration agreement., Alexander J. Bělohlávek., and Obsahuje bibliografické odkazy
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2110. Antiassociative groupoids
- Creator:
- Braitt, Milton, Hobby, David, and Silberger, Donald
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- groupoid and unification
- Language:
- English
- Description:
- Given a groupoid hG, ⋆i, and k ≥ 3, we say that G is antiassociative if an only if for all x1, x2, x3 ∈ G, (x1 ⋆ x2) ⋆ x3 and x1 ⋆ (x2 ⋆ x3) are never equal. Generalizing this, hG, ⋆i is k-antiassociative if and only if for all x1, x2, . . . , xk ∈ G, any two distinct expressions made by putting parentheses in x1 ⋆ x2 ⋆ x3 ⋆ . . . ⋆ xk are never equal. We prove that for every k ≥ 3, there exist finite groupoids that are k-antiassociative. We then generalize this, investigating when other pairs of groupoid terms can be made never equal.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public