The reports of analgesic effects of benzodiazepines are inconsistent. There is evidence of a hyperalgesic effect induced by activation of supraspinal GABAA receptors and an antinociceptive effect induced by activation of receptors located in the spinal cord (dorsal horns). The aim of the study was to discover whether the systemic administration of a benzodiazepine agent alprazolam increases the systemic analgesic efficacy of non-opioid analgesic ibuprofen. Experimental studies combining these agents have not yet been published. We used three experimental methods - writhing test (with acetic acid), tail-flick test and plantar test to assess analgesic action. The drugs were administered orally. Augmentation of the analgesic effect of ibuprofen by alprazolam was proved for the writhing test at a dose of 30 mg/kg of ibuprofen and alprazolam 1 mg/kg. The reaction time of the combination was significantly prolonged in comparison with ibuprofen alone. The results of the tail-flick test and plantar test were negative. The effect of ibuprofen was not enhanced by alprazolam in tests of acute thermal pain. Our results have demonstrated that the analgesic action of ibuprofen is only weakly enhanced by alprazolam., T. Doležal, M. Kršiak., and Obsahuje bibliografii
Let H be a finite abelian group of odd order, D be its generalized dihedral group, i.e., the semidirect product of C2 acting on H by inverting elements, where C2 is the cyclic group of order two. Let Ω (D) be the Burnside ring of D, Δ(D) be the augmentation ideal of Ω (D). Denote by Δn(D) and Qn(D) the nth power of Δ(D) and the nth consecutive quotient group Δn(D)/Δn+1(D), respectively. This paper provides an explicit Z-basis for Δn(D) and determines the isomorphism class of Qn(D) for each positive integer n., Shan Chang., and Obsahuje seznam literatury
Deterministic measures of stability are used for some parameters of graphs as connectivity, covering number, independence number and dominating number. For a long time, in the graph theory any vertex is considered with its neighbourhood. By means of this idea, we define the accessible set and the accessibility number of a connected graph. In this paper we search the accessibility number and other parameters of augmented cubes.
In this paper, the augmented Lagrangian method is investigated for solving recourse problems and obtaining their normal solution in solving two-stage stochastic linear programming problems. The objective function of stochastic linear programming problem is piecewise linear and non-differentiable. Therefore, to use a smooth optimization methods, the objective function is approximated by a differentiable and piecewise quadratic function. Using quadratic approximation, it is required to obtain the least 2-norm solution for many linear programming problems in each iteration. To obtain the least 2-norm solution for inner problems based on the augmented Lagrangian method, the generalized Newton method is applied.
The library of the Order of St Augustine in the Lesser Town of Prague, comprising more than 18,000 volumes, is an extraordinary book set of significant scientific and historical value. Nevertheless, a scientific study that would cover the entire history of the library was not available until now. This article provides a brief outline of the history of the monastic library at St Thomas, mentioning some remarkable figures that have contributed to its prosperity. The introductory part brings information on the binding rules governing the librarian practice in the monastic libraries of the Order of Saint Augustine in the Middle Ages. Because of the long time span, this treatise has been divided into two parts - the medieval and modern history of the library. Particular attention is paid to two periods - the 14th and 18th centuries, during which some members of the Order held leading positions at the university in Prague and, through their pastoral, preaching and educational activities, they were actively involved in the social, cultural and spiritual edification of broad social classes., Veronika Sladká., Obsahuje anglický abstrakt a shrnutí., and Obsahuje bibliografii
This study focuses on the early modern history of the monastic library of the Order of St Augustine at St Thomas in Prague. On the basis of archival sources (monastic chronicles, the catalogue of the members of the Order) and research into provenances in extant collections, this paper primarily aims to map the development of the Augustinian library in the 16th and 17th centuries. Provenance research has discovered that the monastic library was mainly used for monastic studies and for preaching and pastoral activities of the Augustinians. The research into book provenances has revealed numerous personal ties between the Lesser Town Augustinians and people at the court of Rudolph II. The results of the archival and provenance research have not confirmed the hypothesis of the complete looting of the library at the end of the Thirty Years’ War, but neither have they clearly proved the true extent of the losses suffered by the library. The research has shown the primary role of the library within the Order of St Augustine in the Czech lands and has indicated the position of the library in a broader social and cultural context., Veronika Sladká., and Obsahuje bibliografické odkazy