Alterations in mitochondrial parameters are an important hallmark of Huntington’s disease (HD). The ubiquitous expression of mutant huntingtin raises the prospect that mitochondrial disturbances can also be detected and monitored through buccal epithelial cells. In a group of 34 patients with Huntington’s disease and a group of 22 age-related healthy volunteers, respiratory complex I and IV protein quantities in buccal epithelial cells were measured using the dipstick immunocapture assay. The protein quantity of respiratory complex I correlates with age (r = 0.427, P = 0.026, FWE-P = 0.156) in the patient group, but not in the group of healthy subjects. Our non-invasive approach allows us to obtain valuable information for the studies of mitochondrial biochemical parameters in patients with neurodegenerative diseases and could also be useful in epidemiological studies. and Corresponding author: Hana Hansíková
Buckling and postbuckling behaviour of a delaminated plate subjected to shear loading has been studied by means of the finite element analysis. The plate was assumed to contain either one or two circular delamintions of various diameteers and of various out-of-plane and in-plane positions. The size of the plate corresponded to the size of laminate panels used in aircraft structures. It was therefore possible to assess the practical applicability of numerous studies which focused on the buckling behaviour of substantially smaller plates. and Obsahuje seznam literatury
This article discusses the thought of the Czech Marxist philosopher, writer, and poet Egon Bondy (1930–2007) and his dialectical interpretation of Buddhist philosophy, which strongly influenced Bondy’s “nonsubstantial ontology” with its teaching about the Emptiness (śūnyatā) of all entities, the central concept in the philosophy of the Buddhist monk Nāgārjuna (ca 150–250 AD). The second, shorter part of the article outlines recent developments in the field of philosophy inspired by Marxism and Buddhism.
The article presents different attitudes of Buddhist ethics and onthology towards plants in the course of the long history of the Doctrine from its beginings to contemporary teachers. To demonstrate the broader context and trace possible sources of Buddhist thought on this matter, pre-Buddhist Indian traditions and Jainism are also discussed. The main aim is to tackle the question whether plants have been regarded as sentient beings or not. Thus, the article mainly deals with for this purpose the most relevant Buddhist texts, scholars and time periods, namely the ancient layers of the Pali Canon, Japanese esoteric schools (Tendai, Shingon) and contemporary \buddhist preachers. The answer is much more complex than might be expected and varies across texts and scholars. Its extreme poles of 1. a sharp rejection of plants as sentient beings, and 2. plants attaining the nirvana merely by completing the vegetation process are shown., Jakub Kocurek., and Obsahuje bibliografii