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Start Over Format electronic Subject dospělí Subject ženské pohlaví Type srovnávací studie

1. Effectivenes of spironolacton in complex therapy of rheumatoid arthritis

Creator:
Komarova, Elena and Rebrov, Borys
Format:
electronic, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, srovnávací studie, and TEXT
Subject:
revmatoidní artritida--diagnóza--etiologie--farmakoterapie, antagonisté mineralokortikoidních receptorů--terapeutické užití, spironolakton--terapeutické užití, výsledek terapie, kvalita života, cytokiny--účinky léků, kohortové studie, statistika jako téma, dospělí, ženské pohlaví, lidé, mužské pohlaví, and lidé středního věku
Language:
English
Description:
Aldosterone blocker Spironolactone has anti­inflammatory, anti­proliferative and anti­oxidative effects, that is why pathogenetically it is expedient to use it in complex therapy of rheumatoid arthritis. Material and methods: 46 patients with RA took 25­50 mg/day of Spironolactone during 12 months as an addition to standard therapy, the comparison group consisted of 47 patients that got only standard therapy, all the patients were fully examined prior and post the treatment. Results: complex RA therapy leads to improved VAS, HAQ, the antioxidative potential index F; decreased blood concentrations of TNF­α, ICAM­1, FGF and VEGF in contrast to standard therapy. Complex therapy made reduced the DAS 28 more > 0.6. Conclusions: applying of Spironolactone in complex therapy of rheumatoid arthritis contributes to more pronounced improvement in indices of articular syndrome and patients life quality, reduce of anti­inflammatory, anti­proliferative and angiogenic cytokines, and more effectively reduces the activity of the disease comparing to standard therapy., Elena Komarova, Borys Rebrov, and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

2. The content of protective barrier of the stomach in patients with duodenal ulcer associated and non-associated with h. pylori infection

Creator:
Yakubov, Abdujalol Vahabovich and Pulatova, Nargiza Ihsanovna
Format:
electronic, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, srovnávací studie, and TEXT
Subject:
dvanáctníkové vředy--diagnóza--mikrobiologie--patofyziologie, žaludeční sliznice--sekrece, žaludeční šťáva--chemie, fukosa--analýza--nedostatek, infekce vyvolané Helicobacter pylori--komplikace--patofyziologie, pozorovací studie jako téma--statistika a číselné údaje, kyseliny sialové--analýza, stupeň závažnosti nemoci, prognóza, dospělí, ženské pohlaví, lidé, mužské pohlaví, and lidé středního věku
Language:
English
Description:
The condition of the protective barrier of the stomach in patients with duodenal ulcer associated and non-associated with H. pylori infection has been studied. The state of gastric mucosal barrier was studied in 72 patients with peptic ulcer disease association with H. pylori and 26 patients without H. pylori by determining the content of insoluble glycoproteins and its fractions in the basal portion of the gastric juice. In a comparative perspective the state of these indicators were studied depending on the association with H. pylori and the severity of the disease. In patients with H. pylori, damages of protective mucus barrier are characterized by the significant shortage of fucose, which is considered to be the main component of the insoluble glycoproteins. In patients without H. pylori, status of mucosal barrier is characterized by uniform and less significant reduction in the content of fractions of insoluble glycoproteins. In this patients the reduction of insoluble glycoproteins is not dependent on the frequency of exacerbation. The content of fucose in the mucous gel of gastric juice is a diagnostic criterion for determining the frequency of recurrence of the disease in patients with H. pylori infection., Abdujalol Vahabovich Yakubov, Nargiza Ihsanovna Pulatova, and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public