Metabolic syndrome is a prevalent, complex condition. The search for genetic determinants of the syndrome is currently undergoing a paradigm enhancement by adding systems genetics approaches to association studies. We summarize the current evidence on relations between an emergent new candidate, zinc finger and BTB domain containing 16 (ZBTB16) transcription factor and the major components constituting the metabolic syndrome. Information stemming from studies on experimental models with altered Zbtb16 expression clearly shows its effect on adipogenesis, cardiac hypertrophy and fibrosis, lipid levels and insulin sensitivity. Based on current evidence, we provide a network view of relations between ZBTB16 and hallmarks of metabolic syndrome in order to elucidate the potential functional links involving the ZBTB16 node. Many of the identified genes interconnecting ZBTB16 with all or most metabolic syndrome components are linked to immune function, inflammation or oxidative stress. In summary, ZBTB16 represents a promising pleiotropic candidate node for metabolic syndrome., O. Šeda, L. Šedová, J. Včelák, M. Vaňková, F. Liška, B. Bendlová., and Obsahuje bibliografii
The data derived from rat models and the preliminary results of human studies provide strong indices of involvement of common ZBTB16 variants in a range of cardiovascular and metabolic traits. This cross-sectional study in the Caucasian cohort of 1517 Czech adults aimed to verify the hypothesis that ZBTB16 gene variation directly affects obesity and serum lipid levels. Genotyping of nine polymorphisms of the ZBTB16 gene (rs11214863, rs593731, rs763857, rs2846027, rs681200, rs686989, rs661223, rs675044, rs567057) was performed. A multivariate bidirectional regression with the reduction of dimensionality (O2PLS model) revealed relationships between basal lipid levels and anthropometric parameters and some minor ZBTB16 alleles. In men, the predictors - age and presence of minor ZBTB16 alleles of rs686989, rs661223, rs675044, rs567057 - were associated with significantly higher body mass index, waist to hip ratio, body adiposity index, waist and abdominal circumferences, higher total cholesterol and LDL cholesterol and explained 20 % of variability of these variables. In women, the predictors - age and presence of the rs686989 minor T allele - were also associated with increased anthropometric parameters and total cholesterol and LDL cholesterol but the obtained O2PLS model explained only 7.8 % of the variability of the explained variables. Our study confirmed that the selected gene variants of the transcription factor ZBTB16 influence the obesity-related parameters and lipid levels. This effect was more pronounced in men., B. Bendlová, M. Vaňková, M. Hill, G. Vacínová, P. Lukášová, D. Vejražková, L. Šedová, O. Šeda, J. Včelák., and Obsahuje bibliografii
The trans-border area of the Sudetes between Žďarky and Pstrążna has attracted Prussian/German, Austrian, Czech and Polish geologists since the middle of the 19th century. The history of mapping of this area reflects the scientific development of geological centres in Berlin, Vienna, Prague and Wrocław. This paper presents a description of the oldest geological maps of Lower Silesia in the context of changing knowledge on the Carboniferous and Cretaceous stratigraphy and on the tectonics of the region. On the basis of DEM and field studies the author presents his own geological map of the area of the Pstrążna Elevation together with a description of the local structural geology. A regional structural model is suggested, that explains all the local elevations as having developed in response to a dextral strike-slip activity of the Žďarky-Jakubowice Fault during late Tertiary to Recent times, at an eastern extension of the Poříčí-Hronov Fault Zone., Jurand Wojewoda., and Obsahuje bibliografii
Minor intelligentsia, significantly influenced by the ideas of the Enlightenment and the policy and practice of the church before 1848, included the bishopric priests. The authors show not only their gradual formation, but on concrete examples they prove their mutual relationships, influences and individual activities. The fates of butcher’s, miller’s, farmer’s or weaver’s boys show, on the one hand, the social and professional variety of these representatives of future small town and village elites, on the other hand they point out to important relationships between centres such as Prague or Vienna and the periphery which, in the early nineteenth century, included Budweis and other cities not just in the South of Bohemia., Miroslav Novotný a Tomáš Veber., and Obsahuje bibliografické odkazy
Metoda zesilování rozmítnutých pulzů vyvinutá Donnou Stricklandovou a Gérardem Mourouem v roce 1985 a oceněná letošní Nobelovou cenou za fyziku způsobila doslova revoluci v konstrukci laserových systémů s vysokým špičkovým výkonem. Maximální intenzita dnešních laserů je až milionkrát vyšší než před 30 lety a jejich využití je celosvětové. Petawattové laserové systémy se uplatňují v celé řadě experimentů z oblasti biologie, fyziky materiálů, urychlování částic či laboratorní astrofyziky. Českou republiku v této oblasti úspěšně reprezentují laboratoře ELI Beamlines v Dolních Břežanech u Prahy, kde jsou v současnosti v provozu dva unikátní laserové systémy terrawatové a petawattové třídy L1 Allegra a L3 HAPLS., The Chirped Pulse Amplification method, developed by Donna Strickland and Gérard Mourou in 1985, which was awarded this year's Nobel Prize in Physics, has revolutionized the field of high peak power laser systems. The maximum intensity of today's lasers is almost a million times higher than it was 30 years ago and their application is worldwide. Experiments using petawatt laser systems range from biology, material physics, and particle acceleration to laboratory astrophysics. The Czech Republic is successfully represented in this field by the ELI Beamlines facility located in Dolní Břežany near Prague, which houses two unique terawatt and petawatt class laser systems L1 Allegra and L3 HAPLS., Lucia Koubíková., and Obsahuje bibliografické odkazy
This contribution gives a brief description of the characteristics of spectral lines formed in the solar chromosphere in the visual range and its continuum in the visual, millimetre, and sub-millimetre (mm-submm) spectral range. The contribution reviews processes responsible for continuum radiation of the limb in the visual range and continua in the mm-submm spectral range. The spectral lines of sodium doublet Na I D1 and D2 are not genuine chromospheric lines since their cores are formed predominately by resonant scattering of radiation from the upper photosphere. Therefore, the cores of Na I D1 and D2 provide information only about chromospheric velocities. An occurrence of the doublet Na I D1, D2 together with helium lines with large excitation and ionization potential indicates an intricate thermodynamic structure of the chromosphere. As numerical simulations indicate, the chromospheric internetwork comprises of cooler cavities surrounded with hotter sheets allowing the occurrence of spectral lines over a large range of excitation and ionization potentials. The contribution accentuates the large diagnostic potential of the mm-submm continua of the chromospheric spectrum. It will be fully exploited after finishing of the ALMA array for the study of the chromospheric fine structure with large angular and temporal resolution., Príspevok podáva stručnú charakteristiku čiarového spektra slnečnej chromosféry vo vizuálnej oblasti a jej spojitého spektra (kontinua) vo vizuálnej, milimetrovej a submilimetrovej (mm-submm) oblasti. Príspevok predstavuje procesy tvoriace vizuálne kontinuum pozorovatel'né na limbe a kontinuá v mm-submm oblasti. Čiary sodíkového dubletu NA I D1 a D2 nie sú v pravom slova zmysle chromosférické, pretože ich jadrá sú tvorené hlavne rezonančným rozptylom žiarenia hornej fotosféry, a preto poskytujú informáciu iba o rýchlostných poliach v chromosfére. Výskyt dubletu Na I D1 a D2 spolu s čiarami hélia s veľkou excitačnou a ionizačnou energiou naznačuje zložitú termodynamickú štruktúru chromosféry. Ako ukazujú numerické simulácie, chromosféra sa v oblastiach mimo magnetickej siete skládá z chladnejších oblastí obalených horúcou látkou, čo umožňuje vznik spektrálnych čiar vo vel'kom rozsahu excitačných a ionizačných energií. Príspevok poukazuje na vel'ký diagnostický potenciál kontinuí v mm-submm oblasti spektra chromosféry, ktorý bude naplno využitý po dokončení rádioteleskopu ALMA pri štúdiu jemnej štruktúry chromosféry s vel'mi vel'kým uhlovým a časovým rozlíšením., Július Koza., and Obsahuje bibliografii
Holanďan Christiaan Huygens významně přispěl k rozvoji mechaniky a optiky v návaznosti na problémy, které řešila astronomie. Je vynálezcem kyvadlových hodin, nejpřesnějšího časoměrného přístroje doby umožňujícího poprvé stanovení zeměpisné délky plujících lodí., The article deals with the life and work of Dutch astronomer, physicist and mathematician Christiaan Huygens. Describing his extensive scientific work, we start with his activities in the field of observational astronomy (e.g. the discovery of the rings and moon of Saturn and the summary of the existing knowledge of the planets in his publication Cosmotheoros). His discovery and quantitative description of centrifugal force contributed significantly to solving problems describes in Newton´s Principia. Huygens is also well-known as a technician and technical designer. He constructed the first pendulum clocks. Last but not least, we describe his work on the impact of solid bodies, when he reflected on the work of R. Descartes and J. Marek Marci., František Jáchim., and Obsahuje seznam literatury
Sofia Kovalevskaya was not only a great Russian mathematician, but also a writer and advocate of women's rights in the 19th century. After concluding her sexondary schooling, Sofia was determined to continue her education at the university level. She travelled to Heidelberg to study mathematics, but discovered there that as a woman she could not graduate. In 1870 she moved to Berlin to study with Karl Meierstrass, in 1874 she was granted a Ph.D. from the Göttingen University. In 1883 she received an invitation from Gösta Mittag-Leffler to lecture at the University of Stockholm. Sophia's most famous work is on the theory of partial differential equations, and on the rotation of a solid body about a fixed point. Sophia died very young, at the age of 41, from pneumonia., Ivo Kraus., and Obsahuje bibliografii
Thomas de Quincey ; přeložil Jaroslav Skalický ; upravil A.V. Vyskočil, V tiráži uvedeno: vydala nakladatelská společnost s r. o. Rozmach v Praze, and Přeloženo z angličtiny