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922. Contents of volume 47 (2000)
- Format:
- Type:
- model:internalpart and TEXT
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
923. Contractile effects of endothelins on isolated human ureter
- Creator:
- Jankovic, S. M., Jankovic, S. V., Stojanovic, V., Stojadinovic, D., Stojadinovic, M., Canovic, D., and Stefanovic, S.
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, hladké svaly, smooth muscles, endothelins, human ureter, intraluminal pressure, 14, and 612
- Language:
- English
- Description:
- The aim of our study was to inve stigate mechanism of action of endothelins 1, 2 and 3 on spontaneous activity, tone and intraluminal pressure of human ureter. Both longitudinal tension and intraluminal pressure were recorded from the isolated segments of proximal human ureter. Endothelins 1, 2 and 3 (5.35x10 -11 M- 5.05x10-8M) produced concentration-dependent tonic contraction and sustained increase in intraluminal pressure of isolated preparations of hum an ureter. Endo thelins 1 and 3 produced also concentration-dependent inhibition of spontaneous, phasic contractions of the isolated preparations. Selective antagonist of ETA receptors BQ123 and selective antagonist of ET B receptors BQ788 produced significant inhibition of endothelin-1-induced tonic contraction (pA2=8.80 and 6.55, respectively) and increase in intraluminal pressure (pA2=8.68 and 7.02, respectively), while they did not affect endothelin-1-induced inhibition of spontaneous activity. Endothelin 1 produces increase in tone and intraluminal pressure of isolated human ureter acting on both ETA and ETB receptors, the first one being functionally more important. On ly endothelins 1 and 3 inhibit spontaneous, phasic activity of human ureter, but this effect was not blocked by selective antagonists of ETA and ETB receptors., S. M. Jankovic ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
924. Contracting endomorphisms and dualizing complexes
- Creator:
- Nasseh, Saeed and Sather-Wagstaff, Sean
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- mathematics, Bass classes, contracting endomorphisms, dualizing complex, Frobenius endomorphisms, G_{C}-dimension, semidualizing complex, 13, and 51
- Language:
- English
- Description:
- We investigate how one can detect the dualizing property for a chain complex over a commutative local Noetherian ring R. Our focus is on homological properties of contracting endomorphisms of R, e.g., the Frobenius endomorphism when R contains a field of positive characteristic. For instance, in this case, when R is F-finite and C is a semidualizing R-complex, we prove that the following conditions are equivalent: (i) C is a dualizing R-complex; (ii) C\sim RHom_{R}(^{n}R,C) for some n > 0; (iii) G_{C}-dim^{n}R < ∞ and C is derived RHom_{R}(^{n}R,C)-reflexive for some n > 0; and (iv) G_{C}-dim^{n}R < ∞ for infinitely many n > 0., Saeed Nasseh, Sean Sather-Wagstaff., and Obsahuje seznam literatury
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
925. Contrasting books on clay mineral science: how should they be judged? (Shortened title: two books on clay mineral science)
- Creator:
- Jeans, Christopher V.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Geologie. Meteorologie. Klimatologie, Neumann, Barbara, rejstříky, indexes, laponite test, critical analysis, accuracy, editorial quality, 7, and 551
- Language:
- English
- Description:
- Clays (2005) and the Handbook of Clay Science (2006) are new textbooks. Clays, written by Alain Meunier, is for those studying earth sciences. The Handbook of Clay Science, edited by Faїza Bergaya, Benny Theng and Gerhard Lagaly, is concerned particularly with the industrial application of clay mineral science. Both books ar e timely and could fill important gaps in the library of mineral science. Their quality as textbooks is discussed. Critical an alysis of editorial accuracy, indexes and user-friendliness indic ate that both books fall short of the high standards that should be the hallmark of academic publication. Their shortcomings seem to be related to widespread problems that may beset commercial publica tion of scientific books., Christopher V. Jeans., and Obsahuje bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
926. Contribution of ABCB1 and CYP2D6 genotypes to the outcome of tamoxifen adjuvant treatment in premenopausal women with breast cancer
- Creator:
- Soňa Argalácsová, Ondřej Slanař, Pavel Vítek, Petra Tesařová, Bakhouche, H., Marcela Dražďáková, Bartošová, O., Tomáš Zima, and Luboš Petruželka
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, farmakogenomika, pharmacogenomics, p-glycoprotein, SNP, tamoxifen, CYP2D6, 14, and 612
- Language:
- English
- Description:
- Recent pre-clinical evidence suggests that the active metabolite of tamoxifen, endoxifen, is a substrate for efflux pump P-glycoprotein. The aim of our study was to evaluate, if the polymoprhisms within ABCB1 gene alter tamoxifen adjuvant treatment efficacy in premenopausal women. Totally 71 premenopausal women with estrogen receptor positive breast cancer indicated for tamoxifen adjuvant treatment were followed retrospectively for median period of 56 months. The gentic polymorphisms of CYP2D6 and ABCB1 were analyzed and potential covariates as tumor grading, staging, age at the diagnosis, comedication, quantitative positivity of ER or PR were also evaluated. Cox proportional-hazards regression model indicated that patients carrying at least one variant allele in ABCB1 rs1045642 had significantly longer time to event survival compared to wild type subjects. Non-significant trend was noted for better treatment outcome of patients carrying at least one variant allele in the SNP rs2032582, while for the CYP2D6 polymorphism poor metabolizer phenotype resulted in worse outcome in comparison to extensive metabolizers subjects with HR of 4.04 (95 % CI 0.31-52.19). Similarly, patients using CYP2D6 inhibitors had non-significantly shorter time-to-event as compared to never users resulting in hazard ratio of 2.06 (95 % CI 0.40-10.63). ABCB1 polymorphisms may affect outcome of tamoxifen adjuvant treatment in premenopausal breast cancer patiens. This factor should be taken into account in addition to the CYP2D6 polymorphism or phenotypic inhibition of CYP2D6 activity., S. Argalácsová, O. Slanař, P. Vítek, P. Tesařová, H. Bakhouche, M. Dražďáková, O. Bartošová, T. Zima, L. Pertuželka., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
927. Contribution of captopril thiol group to the prevention of spontaneous hypertension
- Creator:
- Oľga Pecháňová
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, hypertenze, thioly, hypertension, thiols, spontaneous hypertension, captopril, enalapril, nitric oxide synthase, reactive oxygen species, 14, and 612
- Language:
- English
- Description:
- We aimed to compare the effect of angiotensin converting enzyme (ACE) inhibitors captopril (containing thiol group) and enalapril (without thiol group) on the development of spontaneous hypertension and to analyze mechanisms of their actions, particularly effects on oxidative stress and NO production. Six-week-old SHR were divided into three groups: control, group receiving captopril (50 mg/kg/day) or enalapril (50 mg/kg/day) for 6 weeks. At the end of experiment, systolic blood pressure (SBP) increased by 41 % in controls. Both captopril and enalapril prevented blood pressure increase, however, SBP in the captopril group (121±5 mmHg) was significantly lower than that in the enalapril group (140±5 mmHg). Concentration of conjugated dienes in the aorta was significantly lower in the captopril group compared to the enalapril group. Captopril and enalapril increased NO synthase activity in the heart and aorta to the similar level. Neither captopril nor enalapril was, however, able to increase the expression of eNOS. Both ACE inhibitors increased the level of cGMP. However, cGMP level was significantly higher in the aorta of captopril group. We conclude that captopril, beside inhibition of ACE, prevented hypertension by increasing NO synthase activity and by simultaneous decrease of oxidative stress which resulted in increase of cGMP concentration., O. Pecháňová., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
928. Contribution of Frantisek Matus to the research on conditional independence
- Creator:
- Studený, Milan
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- teorie matroidů, matroid theory, conditional independence, polymatroid, entropy function, semimatroid, semigraphoid, 23, and 007
- Language:
- English
- Description:
- An overview is given of results achieved by F. Matúš on probabilistic conditional independence (CI). First, his axiomatic characterizations of stochastic functional dependence and unconditional independence are recalled. Then his elegant proof of discrete probabilistic representability of a matroid based on its linear representability over a finite field is recalled. It is explained that this result was a basis of his methodology for constructing a probabilistic representation of a given abstract CI structure. His embedding of matroids into (augmented) abstract CI structures is recalled and his contribution to the theory of semigraphoids is mentioned as well. Finally, his results on the characterization of probabilistic CI structures induced by four discrete random variables and by four regular Gaussian random variables are recalled. Partial probabilistic representability by binary random variables is also mentioned., Milan Studený., and Obsahuje bibliografické odkazy
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
929. Contribution of the Institute of Geonics of the ASCR Ostrava to seismological monitoring in Silesia and Northern Moravia
- Creator:
- Holub, Karel, Zdeněk Kaláb, Jaromír Knejzlík, and Rušajová, Jana
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Geologie. Meteorologie. Klimatologie, seizmicita, zemětřesení, seismicity, earthquake, Slezsko (Česko), Silesia (Czechia), natural seismicity, Moravo-Silesian region, microearthquake, 7, and 551
- Language:
- English
- Description:
- The paper presents selected results of seismological observations in Silesia and northern Moravia between 01/2004 - 08/2008, which are based on interpretation of three-component digital recordings at solitary seismic stations operated by the Institute of Geonics of the ASCR Ostrava (IGN) distributed in the region under investigation. Five seismic stations had recorded local tectonic seismic events in a continuous regime until 12/2005, when the grant project GA CR No. 205/03/0999 terminated. Meanwhile, the Ostrava - Krásné Pole (OKC) seismic station have continued in operation as a part of the Czech regional seismological network since 1983 up to present. Other three stations have been operating in a so-called triggered regime. At the mid-January 2007, seismic station in Klokočov village was re-opened in continuous regime. During 55 months of observation, 90 tectonic events have been detected at one or more seismic stations mentioned above. However, database of the Institute of Physics of the Earth of the MU contains more than 640 microearthquakes during the same time. This discrepancy is caused mainly due to a higher concentration of microearthquake foci distributed all over the western part of the region under investigation where the IPE seismic stations are situated. On the other hand, the IGN seismic stations are spread predominantly within the eastern part of the territory, i.e. relatively far from the recent foci, and moreover, some stations are operated using the triggered regime., Karel Holub, Zdeněk Kaláb, Jaromír Knejzlík and Jana Rušajová., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
930. Contribution to experimental geomechanical and seismological measurements in the Jeroným Mine
- Creator:
- Zdeněk Kaláb, Jaromír Knejzlík, Robert Kořínek, Radovan Kukutsch, Markéta Lednická, and Petr Žůrek
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Geologie. Meteorologie. Klimatologie, geomechanické monitorování, seizmicita, geomechanic monitoring, seismicity, medieval Jeroným Mine, seismological monitoring, 7, and 551
- Language:
- English
- Description:
- Experimental geomechanical and seismological measurements are performed in the medieval Jeroným Mine near Čistá (Sokolov district). The main aim of this activity is geomech anical stability evaluation of this monument. Periodical monitoring was started in 2001 whereas quarterly period was applied (measurement of crack development in the mine working, development in changes in convergence cross-sections of linear and spatial workings and fluctuations of water levels in underground spaces). Seismological monitoring was started during reconstruction of partly impassable drainage adit. At present, selected parts of described geomechanical system are newly instrumented to obtain continuous information. Data obtained from periodical and continuous monitoring are presented in this contribution. Interpretation of seismological data on both natural and technical seismicity and fluctuations of water levels is presented in details., Zdeněk Kaláb, Jaromír Knejzlík, Robert Kořínek, Radovan Kukutsch, Markéta Lednická and Petr Žůrek., and Obsahuje bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public