napsal V. Flajšhans, Otisk z Časopisu Musea král. Českého, Obsahuje bibliografické odkazy, and Converted from MODS 3.5 to DC version 1.8 (EE patch 2015/06/25)
The aim of the current study was to clarify the effect of high sucrose diet (HSD) on bile formation (BF) in rats with hereditary hypertriglyceridemia (HHTg). Potentially positive effects were studied for boldine, a natural choleretic agent. Administration of HSD to HHTg rats led to increased triglyceride deposition in the liver. HSD reduced BF as a consequence of decreased biliary secretion of bile acids (BA) and glutathione. Responsible mechanism was down-regulation of hepatic transporters for BA and glutathione, Bsep and Mrp2, respectively. Moreover, gene expressions of transporters for other constituents of bile, namely Abcg5/8 for cholesterol, Abcb4 for phospholipids, and Oatp1a4 for xenobiotics, were also reduced by HSD. Boldine partially attenuated cholestatic effect of HSD by promotion of biliary secretion of BA through up-regulation of Bsep and Ntcp, and by increase in biliary secretion of glutathione as a consequence of its increased hepatic disposition. This study demonstrates mechanisms of impaired BF during nonalcoholic fatty liver disease induced by HSD. Altered function of responsible transporters suggests also potential for changes in kinetics of drugs, which may complicate pharmacotherapy in subjects with high intake of sucrose, and with fatty liver disease. Sucrose induced alterations in BF may be alleviated by administration of boldine., M. Zagorova, A. Prasnicka, Z. Kadova, E. Dolezelova, L. Kazdova, J. Cermanova, L. Rozkydalova, M. Hroch, J. Mokry, S. Micuda., and Obsahuje bibliografii
Thirty-five 35 participants from 13 countries gathered at Villa Lanna July 16-19, 2014 to hear and discuss presentations on the life and work of one of the foremost European philosophers of the 19th century, Bernard Bolzano. Most of the 30 talks given were on philosophy but mathematics and theology. More than a quarter of the participants were research students. Several news stories have drawn attention to recent developments in Bolzano studies. In May the complete English translation of Bolzano’s major work Wissenschaftslehre (Theory of Science) was published. This year nearly three-quarters of the129 volumes of the Bernard Bolzano Gesamtausgabe will appear in print. The program and other details of the meeting can be found at bolzano2014.wordpress.com. The meeting enjoyed generous sponsorship. Details on the dissemination of the papers will appear in due course. This meeting was co-organised by the Institute of Philosophy of ASCR and the International Bernard Bolzano Society, Salzburg. The Society met in Prague in April 2010 on the 200th anniversary of a book of his published in 1810. Dr. Balzano (1781-1848) was a Bohemian mathematician, logician, philosopher and theologian of Italian extraction and taught at the University of Prague (Charles). and Arianna Betti, Steve Russ.