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3672. Evidence knihovních fondů a evidence činnosti v knihovnách jednotné soustavy

Creator:
Vojtek, Zdeněk
Publisher:
Krajská knihovna Maxima Gorkého
Format:
print and 21 s. : il. ; 21 cm
Type:
model:monograph, Text, metodické příručky, volume, and TEXT
Subject:
veřejné knihovny, veřejné knihovny--Česko, evidence knihovních fondů, evidence knihovních fondů--Česko, činnost knihoven, činnost knihoven--Česko, 027, 025, 005.912, and 021
Language:
Czech
Description:
zpracoval Zdeněk Vojtek, Název z obálky, and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3673. Evolokumab a projekt PROFICIO: první výsledky

Creator:
Kraml, Pavel
Format:
print, text, and regular print
Type:
model:article, article, Text, přehledy, and TEXT
Subject:
lidé, analýza podle původního léčebného záměru--statistika a číselné údaje, klinické zkoušky, fáze III - jako téma, statistika jako téma, výsledek terapie, hypolipidemika--aplikace a dávkování--terapeutické užití, injekce subkutánní, LDL-cholesterol--krev--účinky léků, hypercholesterolemie--farmakoterapie, hyperlipoproteinemie typ II--farmakoterapie, kardiovaskulární nemoci--prevence a kontrola, kombinovaná farmakoterapie, monoklonální protilátky--aplikace a dávkování--terapeutické užití, serinové endopeptidasy, konvertasy proproteinů--antagonisté a inhibitory, and evolocumab
Language:
Czech and English
Description:
Projekt PROFICIO zahrnuje 20 klinických studií hodnotících účinek evolokumabu na výskyt kardiovaskulárních onemocnění včetně jeho bezpečnostního profilu a tolerance. Většina zařazených studií sleduje průměrné procentuální snížení koncentrací LDL-cholesterolu za 10 a 12 týdnů podávání evolokumabu ve srovnání se vstupními hodnotami. První výsledky byly prezentovány na přelomu srpna a září 2015 na kongresu Evropské kardiologické společnosti (ESC) v Londýně. Do této subanalýzy bylo zařazeno 3 146 pacientů, kteří absolvovali jednu z vybraných studií 3. fáze klinického zkoušení a kterým byl evolokumab podáván v dávce 140 mg s.c. 1krát za 2 týdny nebo 420 mg s.c. 1krát za 4 týdny. Hodnoty LDL-cholesterolu se po evolokumabu snížily v jednotlivých studiích o 56,5–74,9 % ve srovnání s placebem a o 36,9–44,9 % oproti ezetimibu. Výskyt nežádoucích účinků se nelišil od skupiny užívající placebo. Klíčová slova: evolokumab – projekt PROFICIO – LDL-cholesterol – kardiovaskulární riziko, The PROFICIO project includes 20 clinical studies evaluating the effect of evolocumab on the incidence of cardio­vascular disease including its safety profile and tolerance. Most of the included studies follow the average proportional decrease of LDL-cholesterol concentrations over 10 and 12 weeks of administering evolocumab as compared to the input values. The first results were announced at the congress of the European Society of Cardiology (ESC) in London at the end of August and beginning of September 2015. This subanalysis comprised 3146 patients, who underwent one of the selected studies of phase 3 clinical testing and who were administered a dose of 140 mg s.c. evolocumab once in 2 weeks, or 420 mg s.c. once in 4 weeks. LDL-cholesterol levels decreased after evolocumab by 56.5 – 74.9% in the individual studies as compared to placebo and by 36.9 – 44.9% compared to ezetimib. The incidence of adverse effects did not differ from the group which used placebo. Key words: evolocumab – PROFICIO project – LDL-cholesterol – cardiovascular risk, and Pavel Kraml
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3675. Evoluce tolerance

Creator:
Natália Martínková
Format:
print, bez média, and svazek
Type:
article, text, články, journal articles, model:article, and TEXT
Subject:
Biologické vědy, biologie, plísně, netopýři, biology, molds (Fungi), bats, 2, and 57/59
Language:
Czech
Description:
Czech White-Nose Syndrome Team together with international collaborators discovered mechanisms of tolerance that protect Palearctic bats from white-nose syndrome (WNS), the disease that caused mass die-off in North America. The discovery raises hope for a better future of bats in North American ecosystems. White-nose syndrome (WNS) is caused by a generalist pathogen Pseudogymnoascus destructans with the worst possible characteristics of an infectious fungal agent. The generalist nature of the WNS fungus means that it can infect any bat hibernating in a contaminated cave or mine and, moreover, it may remain viable and virulent, waiting for its hosts until the next hibernation period. Harmless to humans, the WNS fungus kills hibernating North American bats in winter. However, loss of voracious insectivorous bats from agricultural ecosystems may result in economic costs required for increased pest control. Without mass die-offs of bats harbouring the WNS agent in Europe, the response to disease is an enigma. To study the survival crossroads, the Czech WNS Team focused on the relationship between pathogen quantity and disease under natural conditions. High disease prevalence together with high fungal loads in absence of bat population declines in Eurasia indicates disease tolerance mechanisms, where hosts limit harm inflicted by the pathogen but do not hinder its growth. The tolerance mechanisms revealed by the Czech WNS Team is a function of bat adaptation to the presence of the pathogen. and Natália Martínková.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3676. Evoluční koncepce v současném historickovědním studiu kultury: (teorie či narace; co si s nimi dnes počít?)

Creator:
Jan Horský
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Demografie. Populace, historiografie, vyprávění, teorie, historiography, theory, narration, partial developmental processes, 18, and 314
Language:
Czech
Description:
The article defends the possibility of using evolutionary schemes in historical sciences, as models for interpreting cultural-historical changes. It points out the possibilities for maintaining certain space within master narratives for explaining the theories of partial developmental processes. The demographic data could, then, be used as hypothetical indicators of the processes of cultural-historical change., Jan Horský., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3677. Evolution and function of the insect hexamerins

Creator:
Burmester, Thorsten
Format:
print, text, and regular print
Type:
article, bibliography, model:article, and TEXT
Subject:
zoologie, hmyz, hemolymfa, bílkoviny, hexameriny, funkce, evoluce, 595.2/.7, and 591.3
Language:
English
Description:
Hexamerins are hemocyanin-related haemolymph proteins that are widespread in insects and may accumulate to extraordinarily high concentrations in larval stages. Hexamerins were originally described as storage proteins that provide amino acids and energy for non-feeding periods. However, in recent years other specific functions like cuticle formation, transport of hormones and other organic compounds, or humoral immune defense have been proposed. During evolution, hexamerins diversified according to the divergence of the insect orders. Within the orders, there is a notable structural diversification of these proteins, which probably reflects specific functions. In this paper, the different possible roles of the hexamerins are reviewed and discussed in the context of hexamerin phylogeny., Thorsten Burmester, and Lit
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3678. Evolution equations governed by Lipschitz continuous non-autonomous forms

Creator:
Sani, Ahmed and Laasri, Hafida
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
matematika, mathematics, sesquilinear form, non-autonomous evolution equation, maximal regularity, convex set, 13, and 51
Language:
English
Description:
We prove L2-maximal regularity of the linear non-autonomous evolutionary Cauchy problem \dot u(t) + A(t)u(t) = f(t){\text{ for a}}{\text{.e}}{\text{. }}t \in \left[ {0,T} \right],{\text{ }}u(0) = {u_0}, where the operator A(t) arises from a time depending sesquilinear form a(t, ·, ·) on a Hilbert space H with constant domain V. We prove the maximal regularity in H when these forms are time Lipschitz continuous. We proceed by approximating the problem using the frozen coefficient method developed by El-Mennaoui, Keyantuo, Laasri (2011), El-Mennaoui, Laasri (2013), and Laasri (2012). As a consequence, we obtain an invariance criterion for convex and closed sets of H., Ahmed Sani, Hafida Laasri., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3679. Evropa a otázka rakouská na prahu XX. století

Creator:
Chéradame, André and Nerad, František
Publisher:
Samostatnost
Format:
print and 355 s. : il., 3 faks., 14 map.
Type:
model:monograph and TEXT
Subject:
Mezinárodní vztahy, světová politika, politika a vláda, mezinárodní vztahy, propaganda, Evropa střední, 15, and 327
Language:
Czech and French
Description:
André Chéradame ; přel. František Nerad.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

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