IMI is a unique Public-Private Partnership (PPP) between the pharmaceutical industry, represented by the European Federation of Pharmaceutical Industries and Associations (EFPIA), and the European Communities represented by the European Commission. The First Call of the IMI Joint Undertaking was launched by European Commissioner for Science and Research Janez Potočnik and EFPIA President Arthur Higgins on April 30. and Táňa Perglová.
Královská kanonie premonstrátů na Strahově - Strahovská knihovna Praha CZ CS III 67 adl. c, Královská kanonie premonstrátů na Strahově - Strahovská knihovna Praha CZ AM IX 100 adl. 6, Královská kanonie premonstrátů na Strahově - Strahovská knihovna Praha CZ AB VIII 44 adl. 27, Knihovna Akademie věd ČR Praha CZ TF 347 adl. 45, Národní knihovna ČR Praha CZ 50 G 44, Národní knihovna ČR Praha CZ 52 C 12 adl. 56, and BCBT37988
Immunity plays an important role in the reactivity of the organism and, in this context, is an essential factor in the pathogenesis of many diseases. Basically, there is no system or organ in the body, whose dysfunction is not related to immunity consequences. In addition, there are also multisystem diseases simultaneously involving multiple body systems. They are not always caused by weak immunity, but also often by modified immune reactions known as overshooting. The essence of all these diseases is a change in the reactivity of the organism where immunity plays an important role. The immunity as such is then part of the systems of neuroendocrine-immune regulation, which have common mediators and receptors. The establishment of psychoneuroimmunology, a relatively new discipline in neuroscience, contributed to a detailed understanding of these mechanisms between central and peripheral nervous system, the endocrine system and the immune system. This research enabled the uncovering of the nature of stress-diseases and impact of other regulatory disturbances on the function of various body organs and systems of the organism as a whole. The aim of this short review is to show complex interconnections of these relationships to better understand the human health and disease., F. Vožeh., and Seznam literatury
Insect peptidyl-dipeptidase A [angiotensin I - converting enzyme (ACE)] is a soluble single-domain peptidyl-dipeptidase that has many properties in common with the C-domain of mammalian somatic ACE and with the single-domain mammalian ACE. In agreement with a variety of insects, immunocytochemical studies reveal the presence of an ACE-like protein in Locusta migratoria. ACE-like immunoreactivity is present in neurosecretory cells of the pars intercerebralis. These cells have axons projecting into the nervus corporis cardiaci I and into the storage part of the corpus cardiacum, a neuroendocrine organ directly releasing into the aorta. The localisation of ACE in neurosecretory cells is consistent with its proposed role as a processing enzyme that is involved in the generation of active peptide hormones., Dirk Veelaert, Liliane Scoofs, Nathalie Macours, Anick Vandingenen, Arnold De Loof, Elwyn Isaac, Michel Salzet, Roger Huybrechts, and Lit