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23282. Toshihide Maskawa: Životopis: chlapec si přeje stát se vědcem
- Creator:
- Maskawa, Toshihide and Gregora, Ivan
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- Masukawa, Toshihide, 1940-, 20.-21. století, fyzika elementárních částic, fyzici, elementary particle physics, physicists, Japonsko, Japan, japonští fyzici, 6, and 539
- Language:
- Czech
- Description:
- Toshihide Maskawa ; přeložil Ivan Gregora. and Obrázky
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
23283. Total body response to mechanical ventilation of healthy lungs: an experimental study in piglets
- Creator:
- Jiří Kobr, Fremuth, J., Kateřina Pizingerová, Šárka Fikrlová, Petr Jehlička, Honomichl, P., Lumír Šašek, Jaroslav Racek, and Ondřej Topolčan
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, neurohumorální regulace, neurohumoral regulation, mechanical ventilation, inflammatory reaction, organ function, 14, and 612
- Language:
- English
- Description:
- The objective of our study was to assess the influence of mechanical ventilation on healthy body organs. Fifteen piglets (aged 6 weeks, 19-27 kg) were anesthetized, instrumented, and divided into three groups: Group A - spontaneously breathing, group B - mechanically ventilated with tidal volume 6 ml/kg, and group C - ventilated with tidal volume 10 ml/kg for 12 hours. The parameters of lung, heart, liver and kidney functions neurohumoral regulation and systemic inflammatory reaction were recorded initially (time-1) and after 12 hours (time-12) of mechanical ventilation. At the onset of experiment (time-1) the levels of soluble adhesive molecules were higher (CAM; P<0.01), glomerular filtration index and free water clearance were lower (P<0.05) in both ventilated groups than in group A. Right ventricle myocardial performance index was higher (RIMP; P<0.05) in group C when compared with group A. Levels of CAM (P<0.05) and creatinine clearance (P<0.01) were higher, free water clearance was lower (P<0.05) in group C when compared to group B. At time-12 the RIMP (P<0.05) and levels of CAM were increased (P<0.01), creatinine clearance was decreased (P<0.05) in both ventilated groups compared to the same parameter at time-1. Ventilation index was higher (P<0.05), and hypoxemic index was lower (P<0.01) in group C when compared to group B. In conclusion, this study showed that mechanical ventilation induced changes compatible with early inflammatory response in healthy animals. Higher tidal volumes had detrimental effect on ventilatory parameters, reduced myocardial performance and potentiated adverse reaction of other organs., J. Kobr ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
23284. Total HIP arthroplasty in patients with Parkinson's disease
- Creator:
- Pradeep, George Mathew, Šponer, Pavel, Kučera, Tomáš, Grinac, Michal, and Knížek, Jiří
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, časopisecké články, práce podpořená grantem, and TEXT
- Subject:
- staří, staří nad 80 let, náhrada kyčelního kloubu, kohortové studie, ženské pohlaví, nekróza hlavice femuru--komplikace--chirurgie, fraktury kyčle--komplikace--chirurgie, lidé, mužské pohlaví, Parkinsonova nemoc--komplikace--chirurgie, periprotetické fraktury--komplikace--chirurgie, selhání protézy, reoperace, and výsledek terapie
- Language:
- English
- Description:
- The aim of this study is to evaluate the results of total hip arthroplasty in patients with Parkinson's disease during a period of five years, focusing on the assessment of the risks and benefits of surgery. During this period we performed total hip arthroplasty in 14 patients (15 hips) with Parkinson's disease. Patients were evaluated by subjective symptoms and objective findings, with a focus on the use of support while walking and walking distance, severity of Parkinson's disease before surgery and at the time of the last follow-up. During the postoperative period, the following parameters were assessed: length of ICU stay, mobilization, complications, the total duration of hospitalization and follow-up care after discharge. Of the 11 patients (12 hips) followed-up 1-5 years with an average of 3 years after operation 8 cases showed progression of neurological disability. 5 patients (6 hips) showed an increased dependence on the use of support when walking and reduced distance that the patient was able to walk. Subjectively, 10 hip joints were completely painless and 2 patients complained of only occasional mild pain in the operated hip. Complications that were encountered were urinary tract infection (5 patients), cognitive impairment (3 patients) and pressure ulcer (2 patients). We did not observe any infection or dislocation of the prosthesis. Three patients fell and fractured the femur and 3 patients in our cohort died during follow up. Implantation of total replacement is possible with judicious indication after careful evaluation of neurological finding in patients with minimal or mild functional impairment of the locomotor system. Prerequisite for a good result is precise surgical technique and optimal implant position with balanced tension of the muscles and other soft tissues around the hip. and PG. Mathew, P. Sponer, T. Kucera, M. Grinac, J. Knízek
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
23285. Total β-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy
- Creator:
- Lee, S., Grafweg, S., Schneider, T., Jimenez, M., Giacobino, J.-P., Ghanem, A., Tiemann, K., Bloch, W., Müller-Ehmsen, J., Schwinger, R. H. G., and Brixius, K.
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, kardiologie, cardiology, beta-1 adrenoceptor, beta-2 adrenoceptor, beta-3 adrenoceptor, knockout, mice, 14, and 612
- Language:
- English
- Description:
- The present study investigated cardiac function in hearts of mice with total deficiency of the β1-, β2- and β3-adrenoceptors (TKO) in comparison to wildtype mice (WT). We investigated cardiac morphology and echocardiographic function, measured protein expression of Ca2+-regulatory proteins, SERCA 2a activity, myofibrillar function, and performed running wheel tests. Heart weight and heart-to-body weight ratio were significantly smaller in TKO as compared to WT. This was accompanied by a decrease in the size of the cardiomyocytes in TKO. Heart rate and ejection fraction were significantly diminished in TKO as compared to WT. Protein expressions of SERCA 2a, ryanodine receptor and Na+/Ca2+-exchanger were similar in TKO and WT mice, but phospholamban protein expression was increased. PKAdependent phosphorylation of phospholamban at serine 16 was absent and CaMKII-dependent phosphorylation at threonine 17 was decreased in TKO. All alterations were paralleled by a decrease in SERCA 2a-activity. A similar maximal calciumdependent tension but an increased myofibrillar calciumsensitivity was measured in TKO as compared to WT. We did not observe relevant functional impairments of TKO in running wheel tests. In the absence of β-agonistic stimulation, SERCA 2a activity is mainly regulated by alterations of phospholamban expression and phosphorylation. The decreased SERCA 2a activity following β-adrenoceptor deficiency may be partly compensated by an increased myofibrillar calcium-sensitivity., S. Lee ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
23286. Totálna duodenopankreatektómia pre metastázy renálneho karcinómu − kazuistika
- Creator:
- Donát, Róbert, Sabol, Martin, and Durdík, Štefan
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, kazuistiky, and TEXT
- Subject:
- lidé, lidé středního věku, ženské pohlaví, nádory ledvin, nádory slinivky břišní--chirurgie--sekundární, pankreatoduodenektomie, karcinom z renálních buněk, tomografie rentgenová počítačová, pozitronová emisní tomografie, multiplicitní metastázy, and izolované pankreatické metastázy
- Language:
- Czech, Slovak, and English
- Description:
- Úvod: Frekvencia pankreatických metastáz sa pohybuje od 2 % do 5 % všetkých malígnych tumorov pankreasu. Pankreas je elektívnym miestom metastáz renálneho karcinómu a všeobecne sa vyskytujú v siedmej dekáde a sú obyčajne asymptomatické. Kazuistika: V kazuistike prezentujeme prípad 58 ročnej ženy s multifokálnym a izolovaným postihnutím pankreasu metastázami renálneho karcinómu, ktorý sme riešili totálnou duodenopankreatektómiou. Záver: V selektovaných prípadoch považujeme resekčný výkon na pankrease pri metastázach renálneho karcinómu za indikovaný a zlepšujúci celkové prežívanie pacientov. Kľúčové slová: renálny karcinóm – izolované pankreatické metastázy – totálna duodenopankreatektómia, Introduction: The frequency of pancreatic metastases ranges from 2% to 5%. Pancreas is an elective site for metastases from renal carcinoma. Pancreatic metastases from renal cell carcinoma are frequently the only metastatic site and they typically occur in the seventh decade of life. Case report: We report 1 female patient (aged 58 years) with multifocal and isolated pancreatic metastases of renal cell carcinoma. Total duodenopancreatectomy was performed. Conclusion: In selected cases, pancreatic resection due to renal cell cancer metastases is deemed indicated, improving overall patient survival. Key words: renal cell carcinoma (RCC) − isolated pancreatic metastases − total duodenopancreatectomy, and R. Donát, M. Sabol, Š. Durdík
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
23287. Totální avulze bulbu kombinovaná s poraněním chiazmatu – kazuistika
- Creator:
- Hejsek, Libor, Kaňa, Vítězslav, Rozsíval, Pavel, Dusová, Jaroslava, Stepanov, Alexandr, Trávníček, P., and Tuček, Luboš
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, kazuistiky, and TEXT
- Subject:
- chiasma opticum--patofyziologie--zranění, poranění oka--diagnóza--etiologie--terapie, zraková ostrost, nervus opticus--anatomie a histologie--chirurgie, retrospektivní studie, hemianopsie--etiologie, zraková percepce--fyziologie, enukleace oka, poranění obličeje, hasiči, úrazy a nehody, dospělí, ženské pohlaví, and lidé
- Language:
- Czech and English
- Description:
- Autoři referují o vzácném případu traumatické totální avulze očního bulbu s optickým nervem v úrovni chiazmatu. Kazuistické sdělení retrospektivně popisuje průběh ročního sledování mladé ženy, která byla zraněna při hasičských závodech. Avulze bulbu a optiku, kombinovaná s poraněním chiazmatu, rezultovala v hemianopický defekt druhostranného zorného pole. Při traumatu vzniklo subarachnoidální krvácení do oblasti cisteren chiazmatu, jež spontánně ustoupilo. Nedošlo k rozvoji vaskulárních spazmů mozku. Celková kortikoterapie a neuroprotekce neměla vliv na průběh onemocnění. Během sledovací doby objektivně došlo k descendentní atrofii korespondujících axonů a retinálních gangliových buněk. V současné době neexistuje efektivní terapie poranění v oblasti chiazmatu., The authors report a rare case of complete traumatic avulsion of the eyeball with the optic nerve at the level of chiasm. The case report retrospectively describes a year-long monitoring of a young woman who was injured in fire-fighter races. Avulsion of the globe and optic nerve combined with injured chiasm resulted in contralateral hemianopic visual field defect. The trauma led to subarachnoid hemorrhage in cisterns of chiasm, which spontaneously resolved. There was no development of vascular spasms in the brain. Systemic corticosteroid therapy and neuroprotection did not affect the course of the disease. During the observation period, descending atrophy of the corresponding axons and retinal ganglion cells developed. There is currently no effective therapy of chiasm injuries., and L. Hejsek, V. Kaňa, P. Rozsíval, J. Dusová, A. Stepanov, P. Trávníček, L. Tuček
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
23288. Totální nasazení po Japonsku
- Creator:
- Vasiljevová, Zdeňka
- Format:
- Type:
- model:internalpart and TEXT
- Language:
- Czech
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
23289. Touha po štěstí: povídky
- Creator:
- Josef Sokol
- Publisher:
- F. Šimáček
- Format:
- print, text, regular print, and 187 s. : il. ; 17 cm
- Type:
- model:monograph and TEXT
- Subject:
- Česká próza, 821.162.3-32, (0:82-32), 25, and 821.162.3-3
- Language:
- Czech
- Description:
- Josef Sokol
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
23290. TOUJEO? – nová modalita v inzulinové léčbě
- Creator:
- Skalka, Boris
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, zprávy, and TEXT
- Subject:
- dlouhodobě působící inzulin, lidé, and diabetes mellitus--farmakoterapie
- Language:
- Czech
- Description:
- Boris Skalka
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public