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8792. Intramurální hematom jícnu – kazuistika a přehled literatury

Creator:
Šnajdauf, Martin, Pazdro, Alexandr, Haruštiak, Tomáš, Mrázková, H., and Lischke, Robert
Format:
print, text, and regular print
Type:
model:article, article, Text, kazuistiky, práce podpořená grantem, and TEXT
Subject:
diferenciální diagnóza, hematom--diagnóza--patologie--terapie, ezofágus--patologie, tomografie rentgenová počítačová, hospitalizace, gastroskopie, staří nad 80 let, ženské pohlaví, and lidé
Language:
Czech and English
Description:
Intramurální hematom jícnu je vzácně se vyskytující diagnóza. Prezentuje se retrosternální bolestí, dysfagií či hematemezou. Je způsoben barotraumatem či přímým poraněním jícnu, nebo se může objevit spontánně bez zjevné příčiny, což je častější u pacientů užívajících antiagregační či antikoagulační preparáty. Ve většině případů je léčba konzervativní, v ojedinělých případech endoskopická, endovaskulární či chirurgická. Tento článek prezentuje kazuistiku pacientky se spontánním hematomem jícnu řešeným konzervativně a diskuzi o dalších možnostech průběhu a léčby onemocnění., Intramural hematoma of the oesophagus is a rare diagnosis presenting with retrosternal pain, dysphagia and haematemesis. It is caused by barotrauma or direct injury to the esophagus, or it may occur spontaneously without apparent cause, which is more common in patients taking antiplatelet or anticoagulant medications. In most cases, treatment is conservative. Rarely, endoscopic, endovascular or surgical treatment is effective. This article presents a case report of a female patient with spontaneous haematoma of the oesophagus solved conservatively and discusses further possibilities of the course and treatment of the disease., and M. Šnajdauf, A. Pazdro, T. Haruštiak, H. Mrázková, R. Lischke
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

8793. Intraparietální hemoragie tenkého střeva při antikoagulační terapii pacienta jako neobvyklá příčina hemoperitonea

Creator:
Puszkailer, Leo and Smékalová, Sylva
Format:
print, text, and regular print
Type:
model:article, article, Text, kazuistiky, and TEXT
Subject:
hemoperitoneum--etiologie--chirurgie, gastrointestinální krvácení--chemicky indukované--chirurgie--komplikace, střevo tenké--krevní zásobení, warfarin--škodlivé účinky, výsledek terapie, staří nad 80 let, lidé, mužské pohlaví, pooperační komplikace, and demence
Language:
Czech and English
Description:
Autoři prezentují případ náhlé příhody břišní, spontánního hemoperitonea, kde příčinou byla intraparietální hemorhagie tenkého střeva pří hypokoagulačním stavu pacienta, který byl farmakologicky navozený antikoagulační terapií warfarinem. Zamýšlí se nad možnou etiologickou příčinou stavu., The authors present a case of acute abdomen, spontaneous hemoperitoneum, caused by intraparietal hemorrhage of the small intestine in a patient with hypocoagulation that was pharmacologically induced by warfarin anticoagulation therapy. Potential etiology of the described case is considered by the authors., and L. Puszkailer, S. Smékalová
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

8794. Intrapulmonary activation of the angiotensin-converting enzyme type 2/angiotensin 1-7/G-protein-coupled Mas receptor axis attenuates pulmonary hypertension in Ren-2 transgenic rats exposed to chronic hypoxia

Creator:
Václav Hampl, Jan Herget, Jana Bíbová, Alena Baňasová, Zuzana Husková, Zdeňka Vaňourková, Jíchová, Š., Kujal, P., Zdenka Vernerová, Sadowski, J., and Luděk Červenka
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, hypertenze, hypertension, hypoxic pulmonary hypertension, renin-angiotensin system, 14, and 612
Language:
English
Description:
The present study was performed to evaluate the role of intrapulmonary activity of the two axes of the renin-angiotensin system (RAS): vasoconstrictor angiotensin-converting enzyme (ACE)/angiotensin II (ANG II)/ANG II type 1 receptor (AT 1 ) axis, and vasodilator ACE type 2 (ACE2)/angiotensin 1-7 (ANG 1-7)/ Mas receptor axis, in the development of hypoxic pulmonary hypertension in Ren-2 transgenic rats (TGR). Transgene-negative Hannover Sprague-Dawley (HanSD) ra ts served as controls. Both TGR and HanSD rats responded to two weeks' exposure to hypoxia with a significant increase in mean pulmonary arterial pressure (MPAP), however, the increase was much less pronounced in the former. The attenuation of hypoxic pulmonary hypertension in TGR as compared to HanSD rats was associated with inhibition of ACE gene expression and activity, inhibition of AT 1 receptor gene expression and suppression of ANG II levels in lung tissue. Simultaneously, there was an increase in lung ACE2 gene expression and activity and, in particular, ANG 1-7 concentrations and Mas receptor gene expression. We propose that a combination of su ppression of ACE/ANG II/AT 1 receptor axis and activation of ACE2/ANG 1-7/Mas receptor axis of the RAS in the lung tissue is the main mechanism explaining attenuation of hypoxic pulmonary hypertension in TGR as compared with HanSD rats., V. Hampl, J. Herget, J. Bíbová, A. Baňasová, Z. Husková, Z. Vaňourková, Š. Jíchová, P. Kujal, Z. Vernerová, J. Sadowski, L. Červenka., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

8795. Intrarenal gene expression of proinflammatory chemokines and cytokines in chronic proteinuric glomerulopathies

Creator:
Irena Brabcová, Kotsch, K., Petra Hřibová, Loužecká, A., Kateřina Bartošová, Hyklová, K., Lácha, J., Volk, H.-D., and Ondřej Viklický
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Patologie. Klinická medicína, nefrologie, glomerulonefritida, proteinurie, genová exprese, nephrology, glomerulonephritis, proteinuria, gene expression, chemokiny, chemokines, 14, and 616
Language:
English
Description:
Proteinuria has been recently shown to be an independent risk factor for the progression of chronic nephropathies, but the actual mechanisms by which urinary protein load damages renal tissue in humans remain unsolved. Using real-time RT-PCR method we evaluated intrarenal mRNA expression of various cytokines and chemokines in patients with biopsy-proven IgA nephropathy (IgAN, n=11), membranous nephropathy (MN, n=6) and focal and segmental glomerulosclerosis (FSGS, n=6) who exhibited proteinuria over 0.5 g/day. There was a significant positive correlation between the proteinuria extent and the intrarenal RANTES (regulated upon activation normal T cell expressed and secreted) mRNA expression in patients with IgAN, a similar trend was also observed in patients with MN and FSGS. There were no clear relationships between the proteinuria and intrarenal mRNA expression of tumor necrosis factor α, transforming growth factor β1 and monocyte chemoattractant peptide-1. There were no differences in the pattern of cytokine mRNA expression between different glomerulopathies. In conclusion, our results support the hypothesis that lymphocytes, macrophages and their products provoke tissue in jury in response to proteinuria independently of the nature of renal diseases in man., I. Brabcová, K. Kotsch, P. Hřibová, A. Loužecká, K. Bartošová, K. Hyklová, J. Lácha, H.-D. Volk, O. Viklický., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

8796. Intraspecific morphometric variation in myxosporeans

Creator:
Zhai, Yanhua, Whipps, Christopher M, Gu, Zemao, Guo, Qingxiang, Wu, Zizhen, Wang, Hongmei, and Liu, Yang
Format:
print, počítač, and online zdroj
Type:
model:article and TEXT
Subject:
morfologie (biologie), morphology (biology), intraspecific variation, Myxozoa, species differentiation, Myxobolidae, 2, and 59
Language:
English
Description:
Morphometric data from spores of ten myxosporean species were statistically analysed to explore myxosporean intraspecific variation in measurements when obtained from a sample from: (1) the same plasmodium, (2) different plasmodia from the same host and (3) different host individuals and localities. In some cases, significant differences in spore dimensions were found between samples from the same plasmodium, highlighting the difficulty of obtaining representative measurements of myxosporean spore. In addition, significant differences in spore dimensions were found when plasmodia from the same site of infection were compared, suggesting that measurements of spores should come from several different plasmodia of the sampling to increase the reliability of the morphology data. Moreover, significant differences in spore dimensions were observed for most spore dimensions when data were compared between localities. In all cases, there was clear overlap in ranges of dimensions even when means differed significantly. The present statistical analysis shows that intraspecific morphometric variation of myxosporean species commonly occurs, highlighting the importance of reporting ranges of measurements for a species, not just the mean dimensions, and taking into account all evidence when assigning or describing myxosporean species., Yanhua Zhai, Christopher M. Whipps, Zemao Gu, Qingxiang Guo, Zizhen Wu, Hongmei Wang, Yang Liu., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

8797. Intrauterine undernutrition and programming as a new risk of cardiovascular disease in later life

Creator:
Peter Szitányi, Janda, J., and Rudolf Poledne
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, programování, ateroskleróza, kardiovaskulární nemoci, programming, atherosclerosis, cardiovascular diseases, intrauterine undernutrition, low birth weight, risk factors of cardiovascular disease, 14, and 612
Language:
English
Description:
It is believed that atherogenesis is a multifactorial process, which could already start in utero. Development of atherosclerosis progresses over decades and leads to the cardiovascular morbidity and mortality in adulthood. At present, we have no exact explanation for all the risk factors acting in the pathogenesis of atherosclerosis. This review should provide an overview about the possible role of intrauterine undernutrition in the development of risk factors for cardiovascular disease. Intrauterine undernutrition leads to changes in fetal growth and metabolism and programs later development of some of these risk factors. A number of experimental and human studies indicates that hypertension as well as impaired cholesterol and glucose metabolism are affected by intrauterine growth. Intrauterine undernutrition plays an important role and acts synergistically with numerous genetic and environmental factors in the development of atherosclerosis. There is evidence that undernutrition of the fetus has permanent effects on the health status of human individuals., P. Szitányi, J. Janda, R. Poledne., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

8798. Intraventricular pressure gradients in heart failure

Creator:
Guerra, M., Brás-Silva, C., Amorim, M. J., Moura, C., Bastos, P., and Leite-Moreira, A. F.
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, srdeční selhání, heart failure, intraventricular, gradients, diastole, systole, myocardial segments, 14, and 612
Language:
English
Description:
M. Guerra ... [et al.]. and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

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