Pharmacological preconditioning by diazoxide and a model of experimental streptozotocin-induced acute diabetes mellitus (STZ-DM) provided similar levels of cardioprotection assessed as limiting myocardial infarct size. The aim was to explore the possibility of existence of another in vitro mechanism, which could be contributory to cardioprotection mediated by diazoxide treatment. Mitochondrial membrane fluidity and ATP synthase activity in isolated heart mitochondria were determined under the influence of two factors, STZ-DM condition and treatment with diazoxide. Both factors independently increased the ATP synthase activity (p<0.05), as no interaction effect was observed upon the combination of STZ-DM with diazoxide. On the other hand, the mitochondrial membrane fluidity was significantly increased by STZ-DM only; no significant main effect for diazoxide was found. Based on the results from measurements of enzyme kinetics, we assume a direct interaction of diazoxide with the molecule of ATP synthase stimulated its activity by noncompetitive activation. Our present work revealed, for the first time, that cardioprotection induced by diazoxide may not be caused exclusively by mitochondrial KATP opening, but presumably also by a direct interaction of diazoxide with ATP synthase, although the mechanisms for achieving this activation cannot be fully delineated., M. Jašová, I. Kancirová, M. Muráriková, V. Farkašová, I. Waczulíková, T. Ravingerová, A. Ziegelhöffer, M. Ferko., and Obsahuje bibliografii
The stimulating effect of 1-alkyl-1-ethyl piperidinium bromides on the oxygen evolution rate in spinách chloroplasts was caused by rearrangement of thylakoid membrane.
Současné laserové systémy s výkonem na petawattové úrovni obsahují většinou ve své koncové části optické kompresory s ohromnými difrakčními mřížkami. Bude tomu tak navždy, nebo se najde metody, jak vyrobit petawattové laserové svazky v laboratoři na optickém stole? V článku je objasněn princip stimulovaného zpětného Ramanova rozptylu v plazmatu, který by takovouto metodou mohl být., Current laser systems at petawatt-level outputs usually include huge diffraction gratings in the rear-end of optical compressors. Will this be the case forever, or has a new method appeared which makes the production of petawatt laser beams feasible even on an optical lab table? The article explains the principle of the stimulated Raman backscattering in laser plasma which could be the way., Hana Turčičová., and Obsahuje seznam literatury
Polycultural locality in Kuřim with prevailing Neolithic settlement was partly excavated in rescue research, which was carried out by Ústav archeologické památkové péče Brno. Moravian Painted Ware Culture represents insignifi cant component of this settlement. The excavated pottery was chronologically classifi ed into the end of its earlier phase. Regarding objects, there was gained not a very large collection of chipped and polished stone industry. The results of analysis of stone industry contribute to mapping of distribution network of stone material during Neolithic in the north of Brno, mainly in relation to Boskovická brázda, which was an important long-distance communication in prehistory., Martin Kuča., and Obsahuje seznam literatury