Působení člověka a jeho zemědělské činnosti ovlivnilo přirozený vývoj měkkýších společenstev v průběhu holocénu. Nicméně, prehistorické a historické vlivy na přírodu vedly k vytvoření mozaiky rozmanitých stanovišť s vysokou druhovou diverzitou. Ve smutném kontrastu k tomu stojí moderní snahy o vylepšení přírody, jakými jsou různé rekultivace krajiny., Human influence and agriculture affected the natural development of mollusc communities during the Holocene. Nevertheless, prehistorical and historical impacts on nature have created a mosaic of different habitats with high species diversity, in sad contrast to modern attempts to improve nature, such as various landscape reclamations., and Vojen Ložek, Lucie Juřičková.
One of the most abundant immunologic cell types in early decidua is the uterine natural killer (UNK) cell that despite the presence of cytoplasmic granules rich in perforin and granzymes does not degranulate in normal pregnancy. UNK cells are important producers of angiogenic factors that permit normal dilation of uterine arteries to provide increased blood flow for the growing feto-placental unit. Gram-negative bacteria lipopolysaccharide (LPS) administration can trigger an imbalance of pro-inflammatory and anti-inflammatory cytokines impairing the normal immune cells activity as well as uterine homeostasis. The present study aimed to evaluate by immunohistochemistry the reactivity of perforin and α-actin on UNK cell from LPStreated pregnant mice. For the first time, we demonstrate that LPS injection in pregnant mice causes α-actin down regulation, concomitantly with perforin loss in UNK cells. This suggests that LPS alters UNK cell migration and activates cytotoxic granule release., B. Zavan, A. M. do Amarante-Paffaro, V. A. Paffaro Jr., and Obsahuje bibliografii