This article examines the thoughts of Ali Abd al-Raziq, an important Egyptian scholar and author of a book called Islam and the Bases of Rule (al-Islam wa Usul al-Hukm), published in 1925. In this work, Abd al-Raziq presented fundamental arguments in support of the separation of religion and politics, which were fully supported by a very original analysis of Islam's holy text, the Quran, as well as by the historical situation of the Muslim community at the time of the Prophet Muhammad. Although the publication of this book caused a great scandal in Egypt, with its author being forced to withdraw from Egyptian public life for quite a long period of time, the arguments contained in the book represent an important contribution to the debates about the desirable degree of linkage between Islam and politics in the Muslim world., Jan Kondrys., and Obsahuje bibliografii
A list of alien plant species recorded from Svalbard in the summer of 1988 is presented. Two localities, the Russian settlements of Barentsburg and Pyramiden on the Isfjorden, Spitsbergen, were studied. Prior to this study, almost 60 alien species were recorded from Svalbard by other investigators. During the research reported here, 44 taxa were found, 14 of which are new records for the Svalbard archipelago. Six species are considered to be possibly naturalized; however, it is difficult to assess their naturalization status because of the severity of the climate in the study area. A complete list of species is presented, with information on height and phenological stage of particular specimens. Most of the alien plants recorded at the two settlements belong to the family Brassicaceae.
ALKB-8 is a 2-oxoglutarate-dependent di-oxygenase homologous to bacterial AlkB, which oxidatively demethylates DNA substrates. The mammalian AlkB family contains AlkB homologues denominated ALKBH1 to 8 and FTO. The C. elegans genome
includes five AlkB-related genes, homologues of ALKBH1, 4, 6, 7, and 8, but lacks homologues of ALKBH2, 3, and 5 and FTO. ALKBH8 orthologues differ from other AlkB family members by possessing an additional methyltransferase module and an RNA binding N-terminal module. The ALKBH8 methyltransferase domain generates the wobble nucleoside 5-methoxycarbonylmethyluridine from its precursor 5-carboxymethyluridine and its (R)- and (S)-5-methoxycarbonylhydroxymethyluridine hydroxylated forms in tRNAArgUCG and tRNAGlyUCC. The ALKBH8/ALKB-8 methyltransferase domain is highly similar to yeast TRM9, which selectively modulates translation of mRNAs enriched with AGA and GAA codons under both normal and stress conditions. In this report, we studied the role of alkb-8 in C. elegans. We show that downregulation of alkb-8increases detection of lysosome-related organelles visualized by Nile red in vivo. Reversely, forced
expression of alkb-8 strongly decreases the detection of this compartment. In addition, overexpression of alkb-8 applied in a pulse during the L1 larval stage increases the C. elegans lifespan. and Corresponding author: Marta Kostrouchová
The optimization of functions subject to partial differential equations (PDE) plays an important role in many areas of science and industry. In this paper we introduce the basic concepts of PDE-constrained optimization and show how the all-at-once approach will lead to linear systems in saddle point form. We will discuss implementation details and different boundary conditions. We then show how these system can be solved efficiently and discuss methods and preconditioners also in the case when bound constraints for the control are introduced. Numerical results will illustrate the competitiveness of our techniques.
Fundamentals of the theory of system alliances are briefly reviewed. An accent is put on interfaces (IFs). The model of IFs consisting of a pair of finite deterministic automata sharing a part of their internal state space is introduced. The presented model of alliance interface can be successfully implemented for the study of typical phenomena in complex heterogeneous objects with a significant degree of uncertainty.