Týdenní soustředění středoškoláků na "Jaderce" nabízí každému z nich vyzkoušet si po šest dní na vlastní kůži vědeckou práci ve skutečném výzkumném prostoru. Cílem akce je dozvědět se nové informace z oblasti přírodních a technických věd a zažít na vlastní kůži, jak vědci doopravdy pracují a jak náročné to je. Součástí programu jsou i exkurze na vrcholová vědecká pracoviště v Praze. Soustředění je zakončeno malou konferencí, kde středoškoáloci prezentují výsledky vlastního výzkumu a jejich úsilí je završeno sborníkovým příspěvkem. Letos tato akce z důvodů karantény neproběhla, a tak si připomeňme tu loňskou a těšme se na tu budoucí v roce 2021 - některé věci prostě distančně dělat nelze! and Jana Žďárská.
This article deals with pairs of synonymous words in Tamil. These pairs are very frequent in modern Tamil but only a few words constituting these pairs can be considered complete synonyms. Most of them differ in meaning, emotive charge or source of origin. The pairs are arranged into several major groups according to their nature and then commented upon. The article also touches upon the question of the function of these pairs in the language.
Small typographic elements such as pilcrows, pointing fingers, and type-ornaments optically separated the typeset and helped the reader to grasp the text. The latter also boosted the aesthetic quality of the printed work. However, whether such material occurs in a book and to what extent varies with time, genre, and printing house. Any specific use reflects not only the typesetter practice but can also indicate the intentions of the particular printer (printing house) or reading habits of the intended readership. Considering that the Brethren bishops carefully scrutinised and supervised every edition printed in their illegal printing house in Ivančice (South Moravia), one can assume a thoughtful and discreet attitude towards the content, likewise the typography. The present study explores the visual practices adopted by the Brethren for the typesetting of hymnbooks, Bibles, and confessions. The aim is to provide a detailed account of the design and function of the Brethren pilcrows and printers’ ornaments based on a typography analysis of all known pieces printed between 1562-1578 on the Brethren press. The results provide strong evidence that the Brethren developed a sophisticated typographical system to strengthen and partly to reform the Brethren liturgy. The unique way of the Brethren for marking stanzas and repetition within the printed hymns using pilcrows and “trefoil” is an entirely new finding. Whatsmore, a comparison of the Brethren’s book with similar production published by the local printers indicates unprecedented precision of the Brethren’s typesetters devoted to the graphic design of the liturgical texts (hymnbooks, Bibles). Considering the extant historical sources, the outcomes presented here indicate a systematic effort to implement a unified order into Brethren liturgy urged by the leading Brethren bishops., Veronika Sladká., and Obsahuje bibliografické odkazy
The article deals with the typology of Baroque frontispieces in printed books published in Bohemian and Moravian printing houses in 1618-1765, which is viewed in terms of the function of the frontispieces in printing. The paper contains a detailed analysis of the main thematic variants of frontispieces. The thematic variants are analysed with respect to the content and genre of the work concerned with the aim to determine the main marketing strategies of Bohemian and Moravian printers, publishers or booksellers in the visual promotion of their products., Hana Beránková., Obsahuje anglický abstrakt a shrnutí., and Obsahuje bibliografii
The paper studies the typology of the initials following the way of construction of their corpus in the mutual ties in the development – departing from the late antique, considering the Byzantine and Pre-Romanesque and Romanesque types. The modifications of the initials are studied together with the changes of their function in the decoration system and in the cultural-historical context. The contribution also studies the changes of the terminology connected with the typology of the initials.
The paper is engaged with a definition of the typolotgy and modifications fo the caligraphic initials, compared with the typology of painted initials, and also with a comparative study of the terminoloty used in different languages for the specific compositions. The interest is also focused on relations among countries, regions and workshops that participated in the transformations of the caligrafic initials. The subject is studied on a broad period, from the Late Antiquity till the 16th century, but without a typology of fleuronée, only compositions of the body of the initials have been taken into consideration.
The Patent of Toleration of the year 1781 cleared the way for activities of two Protestant churches in the Habsburg Monarchy. In the two borderland regions chosen for analysis - the regions of Děčín and Šluknov - the Protestant inhabitants were affected by the religious influences from Saxony that acquired various forms. From the period before the year 1620 there was, exceptionally, preserved the Lutheran religion, whose followers visited churches on the Saxon side of the border. Also, the regions were continuously settled by Saxon immigrants who were not organized within the structures of the Augsburg confession. Only after the commencement of industrialization and the subsequent wave of Saxon immigration was made possible the establishment of independent Protestant choirs. Absolutely exceptional was the Lutheran choir of Saxon officials in Podmokly that was founded after railroad had been finished in 1851. Already before the year 1850 the mission of the renewed Unity of Brethren from Herrnhut instigated the popular religious movement. At the turn of the nineteenth and twentieth century, religious propaganda of the movement „Away from Rome“ (Los von Rom), in many cases supported from Saxony, found response in these regions. The typology of religious influences from Saxony and their manifestations on the Bohemian side of the border, established on the basis of the examples of Děčín and Šluknov regions, could be used for the nineteenth century also for other borderland regions inhabited predominantly by German-speaking population.
The contraction of gastrointestinal (GI) smooth muscles is
regulated by both Ca2+-dependent and Ca2+ sensitization
mechanisms. Proline-rich tyrosine kinase 2 (Pyk2) is involved in
the depolarization-induced contraction of vascular smooth muscle
via a Ca2+ sensitization pathway. However, the role of Pyk2
in GI smooth muscle contraction is unclear. The spontaneous
contraction of colonic smooth muscle was measured by using
isometric force transducers. Protein and phosphorylation levels
were determined by using western blotting. Pyk2 protein was
expressed in colonic tissue, and spontaneous colonic contractions
were inhibited by PF-431396, a Pyk2 inhibitor, in the presence of
tetrodotoxin (TTX). In cultured colonic smooth muscle cells
(CSMCs), PF-431396 decreased the levels of myosin light chain
(MLC20) phosphorylated at Ser19 and ROCK2 protein expression,
but myosin light chain kinase (MLCK) expression was not altered.
However, Y-27632, a Rho kinase inhibitor, increased
phosphorylation of Pyk2 at Tyr402 and concomitantly decreased
ROCK2 levels; the expression of MLCK in CSMCs did not change.
The expression of P(Tyr402)-Pyk2 and ROCK2 was increased
when CSMCs were treated with Ach. Pyk2 is involved in the
process of colonic smooth muscle contraction through the
RhoA/ROCK pathway. These pathways may provide very
important targets for investigating GI motility disorders.
Incubation of maize NADP-malic enzyme with tetranitromethane (TNM) resulted in a total loss of enzyme activity. The loss of enzyme activity was not observed at pH 6.3 but at pH 8.0. NADP-malic enzyme was inactivated to almost 90 % by incubation with an 80-fold molar excess of TNM for 5 min at 30 °C. The substrate malate or Mg2+ alone gave no protection, while NADP provided considerable protection. NADP in the presence of malate and Mg2+ totally protected the enzyme activity, suggesting that tyrosine residue may be located at or near the active site of maize NADP-malic enzyme. The spectral analysis of the modified enzyme indicated that modification of at least one tyrosine residue per subunit resulted in complete loss of the enzyme activity. The fluorescence study of unmodified and modified enzymes postulated that essential tyrosine residue at maize NADP-malic enzyme is possibly involved in malate binding. and S. R. Rao, B. G. Kamath, A. S. Bhagwat.