Alveolar echinococcosis is a severe chronic helminthic disease that mimics slow-growing liver cancer. The immune evasion strategy of Echinococcus multilocularis Leuckart, 1863 remains poorly understood. The aim of this study was to investigate in vitro the impact of E. multilocularis vesicular fluid (Em-VF) on peripheral blood mononuclear cells (PBMC) and on natural killer (NK) cells. PBMC and NK cells were exposed to Em-VF (1 µg/ml) during six days. The effect of Em-VF was assessed on CD69, viability and proliferation, and on and transforming growth factor β (TGF-β), interferon γ (IFN-γ), interleukin 17 (IL-17) and interleukin 10, using flow cytometry and ELISA, respectively. Exposure to Em-VF had no bearing on PBMC's viability, proliferation and expression of CD69. In contrast, higher levels of IL-17 at day three and of TGF-β at day six were observed in PBMC supernatant after exposure to Em-VF (p < 0.05, Wilcoxon signed-rank test). Exposure to Em-VF induced a significant decrease of CD69 expression of NK cells at day three and a significant decrease of proliferation of NK cells at day six (p < 0.05, Wilcoxon signed-rank test). In contrast, NK cells viability and levels of cytokines did not vary significantly over Em-VF stimulation. Exposure to Em-VF had a significant bearing on activation and proliferation of NK cells. NK cells may play an important role in the immune response of the host against E. multilocularis., Anne-Pauline Bellanger, Valentine Mougey, Jean-René Pallandre, Houssein Gbaguidi-Haore, Yann Godet, Laurence Millon., and Obsahuje bibliografii
Collections of ‘Echinorhynchus salmonis’ from Britain and Ireland deposited in The Natural History Museum, London (1921.7.19.3–12 and 1952.10.30.122–127) were reidentified as Acanthocephalus clavula and Acanthocephalus lucii respectively. The amphipod, Pontoporeia affinis, European intermediate host of E. salmonis, does not occur in the British Isles, so it is concluded that E. salmonis is absent from British and Irish freshwater fishes.
In order to study cardiac pathology in different subtypes of ischemic stroke we examined 165 stroke patients. The 1st group included 90 (54.5%) patients with hemodynamic stroke, the 2nd one - 75 (45.5%) patients with cardioembolic stroke. Control group consisted of 45 individuals without cerebrovascular diseases. Cardiac pathologies with the prevalence of various types of ischemic heart disease were observed in all groups. The parameters of left ventricular stroke volume and ejection fraction were lower in patients with hemodynamic stroke than in other groups, but were within normal limits. Potential sources of cardiogenic embolism were found in all groups: in the 1st group at 74.4%, in the 2nd one at 100%. Thus, most patients with ischemic stroke have different heart defects related to the subtypes of ischemic stroke., Natalya Dadamyants, and Literatura
Rejskovití hmyzožravci (čeleď Soricidae) jsou drobní savci, kterých si v přírodě často sotva všimneme. Vyznačují se však mnoha zajímavostmi, díky kterým rozhodně stojí za naši pozornost. K těmto zajímavostem lze zařadit i schopnost echolokace, tj. schopnost orientovat se v prostoru za pomoci ozvěn cvakání, které vydávají. Kromě cvakání se během pohybu prostředím patrně orientují i pomocí štěbetavých hlasů. Bělozubky hnědé (Suncus murinus) při pohybu v neznámém prostředí také „duní“. Zda se i toto dunění uplatňuje při orientaci v prostoru není zatím jasné. Bělozubky pouštní (Diplomesodon pulchellum) zase při přechodu mezi různými typy substrátu vibrují, a tyto vibrace vytvářené celým tělem jim pravděpodobně pomáhají odhadnout vlastnosti substrátu a vyhnout se tak zbytečnému hrabání v hustém písku., Shrews (Soricidae) are small mammals that can be barely noticed in nature. However, there are many interesting facts that make them noteworthy, including echolocation - the ability to navigate with the help of echoes of the clicks they produce. Apart from the clicks, twitters are also probably used for navigation. The Asian House Shrew (Suncus murinus) moving through an unfamiliar environment produces boom, but it is not yet clear whether this sound is used for navigation. The Piebald Shrew (Diplomesodon pulchellum) produces body vibrations in response to a change in the substrate under their feet. These vibrations may be used for exploration of substrate density to avoid digging in dense sand., and Irena Schneiderová.
Rejskovití hmyzožravci (Soricidae) vydávají v nejrůznějších situacích mnoho typů hlasů. Dospělí jedinci se ozývají, pokud jsou v nebezpečí nebo se dostanou do potyčky s jiným jedincem svého druhu, během námluv a páření nebo při kontaktu s potomky. Také mláďata vydávají nejrůznější hlasy, jimiž se často snaží upozornit na své strádání nebo udržet kontakt s matkou a sourozenci. Přestože v poslední době přibývá publikací zabývajících se problematikou akustické komunikace rejskovitých, je to stále poměrně neprobádaná oblast. Mnohé otázky by mohly být zodpovězeny studiem bělozubky hnědé (Suncus murinus), která dobře prospívá i v péči člověka., Shrews (Soricidae) utter many types of vocalization in various situations. Adult individuals emit vocalizations when they are in danger or in a fight with conspecifics, during courtship and mating or when they keep contact with their offspring. Juveniles utter variable vocalizations mostly to prevent their discomfort and to keep contact with their mother and siblings. Although the number of publications has increased recently, acoustic communication among shrews still remains a quite unexplored field. Our knowledge might be significantly expanded by studying the Asian House Shrew (Suncus murinus), a species that can be successfully kept and bred in captivity., and Irena Schneiderová.
K tisku upravil za přispění vynikajících odborníků Jan Eckert, odborný hospodářský učitel v Litomyšli a majitel "České Hospodyně" vycházející v Chrudimi