Nephrotoxicity of cisplatin (CP) involves renal oxidative stress and inflammation, and sesamin (a major liganin in many plants) has strong antioxidant and antiinflammatory actions. Therefore, we investigated here the possible mitigative action of sesamin on CP nephrotoxicity in rats. Sesamin was given orally (5 mg/kg/day, 10 days), and on the 7th day, some of the treated rats were injected intraperitoneally with either saline or CP (5 mg/kg). On the 11th day, rats were sacrificed, and blood and urine samples and kidneys were collected for biochemical estimation of several traditional and novel indices of renal damage in plasma and urine, several oxidative and nitrosative indices in kidneys, and assessment of histopathological renal damage. CP significantly and adversely altered all the physiological, biochemical and histopathological indices of renal function measured. Kidneys of CP‐treated rats had a moderate degree of necrosis. This was markedly lessened when CP was given simultaneously with sesamin. Sesamin treatment did not significantly alter the renal CP concentration. The results suggested that sesamin had ameliorated CP nephrotoxicity in rats by reversing the CP-induced oxidative stress and inflammation. Pending further pharmacological and toxicological studies sesamin may be considered a potentially useful nephroprotective agent.
The abundance, diet, and prey relationships of American mink Mustela vison were studied in the Słońsk Reserve (W Poland) on two plots: shore and reservoir. Estimated mink number within the Reserve was 69 in autumn–winter 1998/1999 and 50 during spring 1999. The diet of American mink consisted mainly of mammals, birds and fish. In autumn–winter, birds formed 4–16%, whereas mammals constituted up to 56% and fish up to 62% of the biomass consumed, depending on the plot. In spring and summer, however, birds formed 45–60% of the biomass consumed in the reservoir and 35–46% of the biomass taken by mink on the shore. The European coot Fulica atra was the most frequently consumed prey. In spring, mink removed 7.8% (N=278 killed birds) of coots nesting in the Reserve, 1.8% (N=9) of breeding grebes Podiceps spp. and 11.2% of ducks (N=93 taken birds). On straw platforms only 13.6% of greylag geese Anser anser broods were successful. From 35 to 77% of the nests on straw platforms were destroyed by mink. In wooden boxes 46.4% of mallard Anas platyrhynchos and 33.3% of shelduck Tadorna tadorna nests were successful. American mink destroyed 22–40% of the nests in boxes. However, the arrival of American mink to the Słońsk Reserve has not resulted in a noteworthy decrease in waterfowl populations.
In this article, the author traces how the lessons of the Munich Agreement of September 1938 (on the basis of which Czechoslovakia was forced to cede the predominantly ethnic-German Sudetenland to Nazi Germany) were projected into US foreign policy. In Part One of the essay, based on published sources and unpublished documents from American archives, the topic is covered from the late 1930s to the outbreak of the Korean War (which is discussed in Part Two, to be published in the next issue of Soudobé dějiny). The author looks at immediate American reaction to the North Korean attack on South Korea in June 1950, and then returns to autumn 1938 to test his hypothesis that behind the unusual unity of this reaction was the ingrained negative attitude of the United States to the policy of appeasement. He demonstrates that since the late 1930s the terms ‘Munich’ and ‘appeasement’ have remained forever linked in US policy and US public discourse, and he discusses the transformations of the perception of the two concepts during the Second World War, after the war, and at the beginning of the Cold War. The lessons of Munich, he argues, have drawn on the idealistic as well as the pragmatic sources of US policy, because they stem from the conviction that appeasement is immoral and does not pay. Whereas in Roosevelt’s policy the general lesson was not to allow Hitler’s expansion, Harry S. Truman, Roosevelt’s successor in the White House, had to use the lessons, despite his own self-restraint, to try to counter the steps of a wartime ally, Stalin’s Soviet Union. The Communist take-over in Czechoslovakia in February 1948 and the blockade of the western sectors of Berlin beginning in the summer of that year were important events on this path.The author further considers the infl uence of this factor on the US approach taken in the Korean War in the early 1950s. He seeks to demonstrate that the decision of the Truman Administration to substantially intervene in this confl ict was a direct consequence of the negative attitude to the policy of appeasing an aggressor. This attitude was also shared by the American public, regardless of party affi liation and political sympathies. Arguments based on the rejection of appeasement, however, soon began to be used by the Republicans as ammunition in the election campaign against the incumbent Democrats and the choice of strategy also became a matter of dispute in the choice of strategy on the Korean battlefi eld after China entered the war. Whereas the White House wished to avoid an unlimited confl ict with China, the Commander-in-Chief of the United Nation Command in Korea, General Douglas MacArthur (1880–1964), was in favour of an uncompromising approach and in fact ceased to obey President Harry S. Truman (1884-1972). After being relieved of his command by Truman, MacArthur became the chief critic of his policies and a hero of Truman’s Republican opponents. In spring 1951, the Republicans organized a special Senate committee hearing on the circumstances of MacArthur’s suspension. The author looks in detail at this exceptional clash in post-war US domestic politics, which was meant to be triumphantly used against MacArthur, but gradually changed into a debacle in consequence of, among other things, the compelling testimonies of Secretary of State Dean Acheson (1893-1971) and Secretary of Defense George C. Marshall (1880-1959). In his conclusion, the author seeks to demonstrate how other US presidents returned to the ‘lessons of Munich’, and he argues that these lessons became Truman’s lasting political legacy and as such became fi rmly rooted in American political discourse. and Přeložil: Jiří Mareš