In this review we summarize several synthetic approaches to the advanced synthesis of star-like polymer-based drug carriers. Moreover, their application as nanomedicines for therapy or the diagnosis of neoplastic diseases and their biodistribution are reviewed in detail. From a broad spectrum of star-like systems, we focus only on fully water-soluble systems, mainly based on poly(ethylene glycol) or N-(2-hydroxypropyl)methacrylamide polymer and copolymer arms and polyamidoamine dendrimers serving as the core of the star-like systems., L. Kotrchová, L. Kostka, T. Etrych., and Obsahuje bibliografii
Biological membrane mimetics, such as liposomes, lipid bilayers and model membranes, are used in a broad range of scientific and technological applications due to the unique physical properties of these amphiphilic aggregates. They serve as platforms for studying soft matter physics of membranes and membrane dynamics, interactions of bilayers with drugs, and effects of various additives of environmental changes. State-of-the-art research takes advantage of the combination of the brilliance of X-ray scattering sources with peculiar properties of neutrons and the power of computer simulations. The advances in chemistry, and in particular the possibility of deuteration, enables improved experimental spatial resolution and the ability to pi-point labels within membranes. It is only a matter of time for many biological functions, which occur at the membrane interface, to be matched with the structural properties of these membranes., Článok referuje o zákonitostiach stavby lipidových membrán a ich interakciách s biologicky aktívnymi molekulami. Vplyv iónov nachádzajúcich sa v prirodzenom prostredí bunkovej membrány, anestetický efekt alkánov a účinok cholesterolu a melatonínu pri zabudovaní do membrány je diskutovaný najmä z pohľadu zmeny štruktúry lipidovej matrice membrány. Štruktúrne výsledky sú získané pomocou experimentálnych prístupov, pričom dôraz sa kladie na pokrok dosiahnutý v metódach využívajúcich moderné zdroje röntgenového žiarenia a neutrónov., Norbert Kučerka., and Obsahuje bibliografii