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24262. Nanolime - Small Particles with a Great Potential /
- Creator:
- Dietze, Claudia
- Type:
- text and studie
- Subject:
- Chemie. Mineralogické vědy, konzervace, kameny, světové dějiny od r. 1945 do současnosti, vědy o neživé přírodě, přírodní prostředí, astronomie, and chemické vědy, alchymie
- Language:
- English
- Rights:
- unknown
24263. Nanoparticles show potential to retard bradyzoites in vitro formation of Toxoplasma gondii
- Creator:
- Adeyemi, Oluyomi Stephen, Murata, Yuho, Sugi, Tatsuki, Han, Yongmei, and Kato, Kentaro
- Format:
- print, počítač, and online zdroj
- Type:
- model:article and TEXT
- Subject:
- infekce, lékařská biochemie, nanomedicína, toxoplazmóza, infections, medical biochemistry, nanomedicine, toxoplasmosis, cyst, 2, and 59
- Language:
- English
- Description:
- Toxoplasmosis is a common parasitic disease caused by Toxoplasma gondii (Nicolle et Manceaux, 1908), an obligate parasite capable of infecting a range of cell types in almost all warm-blooded animals. Upon infecting an intermediate host, the parasites differentiate into tachyzoites which rapidly infect host tissues. Usually, the invading parasites are cleared by the immune system and administered drugs, but some tachyzoites differentiate into bradyzoites forming tissue cysts. These tissue cysts could serve as a source for re-infection and exacerbations. Currently, treatment for toxoplasmosis is limited and, moreover, there are no drugs for treating the cystic stage thus rendering toxoplasmosis a global burden. Recently, we demonstrated that inorganic nanoparticles showed promising activity against the tachyzoite stage T. gondii. In the present study, we evaluated nanoparticles for effect on bradyzoite formation in vitro. Data revealed that the nanoparticles limited bradyzoite burden in vitro. Further, the nanoparticles decreased the bradyzoite-specific BAG-1 promoter activity relative to the untreated control under a bradyzoite-inducing culture condition, even though this reduction in BAG-1 promoter activity waned with increasing concentrations of nanoparticles. In contrast, a parallel experiment under normal cell culture conditions showed that the nanoparticle treatment mildly increased the BAG-1 promoter activity relative to the untreated control. Taken together, the findings are evidence that nanoparticles not only possess anti-tachyzoite potential but they also have anti-bradyzoite potential in vitro., Oluyomi Stephen Adeyemi, Yuho Murata, Tatsuki Sugi, Yongmei Han, Kentaro Kato., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
24264. Nanostruktury a nanojevy v křemíku
- Creator:
- Kočka, Jan, Fejfar, Antonín, Mutombo, Pingo, and Cháb, Vladimír
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- fyzika, nanočástice, křemík, physics, nanoparticles, silicon, 6, and 53
- Language:
- Czech and English
- Description:
- Jan Kočka, Antonín Fejfar, Pingo Mutombo, Vladimír Cháb. and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
24265. Nanotechnology - new trends in the treatment of brain tumours
- Creator:
- Krůpa, Petr, Řehák, Svatopluk, Diaz-Garcia, Daniel, and Filip, Stanislav
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, časopisecké články, práce podpořená grantem, přehledy, and TEXT
- Subject:
- antitumorózní látky--terapeutické užití, nádory mozku--terapie, diagnostické zobrazování, nosiče léků, systémy cílené aplikace léků, genetická terapie, genetické vektory, lidé, nanočástice--terapeutické užití, nanotechnologie--trendy, nanotrubičky, and transplantace kmenových buněk
- Language:
- English
- Description:
- High grade gliomas are some of the deadliest human tumours. Conventional treatments such as surgery, radiotherapy and chemotherapy have only a limited effect. Nowadays, resection is the common treatment of choice and although new approaches, such as perioperative magnetic resonance imaging or fluorescent microscopy have been developed, the survival rate of diagnosed patients is still very low. The inefficacy of conventional methods has led to the development of new strategies and the significant progress of nanotechnology in recent years. These platforms can be used either as novel imaging tools or to improve anticancer drug delivery into tumours while minimizing its distribution and toxicity in healthy tissues. Amongst the new nanotechnology platforms used for delivery into the brain tissue are: polymeric nanoparticles, liposomes, dendrimers, nanoshells, carbon nanotubes, superparamagnetic nanoparticles and nucleic acid based nanoparticles (DNA, RNA interference [RNAi] and antisense oligonucleotides [ASO]). These nanoparticles have been applied in the delivery of small molecular weight drugs as well as macromolecules - proteins, peptides and genes. The unique properties of these nanoparticles, such as surface charge, particle size, composition and ability to modify their surface with tissue recognition ligands and antibodies, improve their biodistribution and pharmacokinetics. All of the above mentioned characteristics make of nanoplatforms a very suitable tool for its use in targeted, personalized medicine, where they could possibly carry large doses of therapeutic agents specifically into malignant cells while avoiding healthy cells. This review poses new possibilities in the large field of nanotechnology with special interest in the treatment of high grade brain tumours. and P. Krůpa, S. Řehák, D. Diaz-Garcia, S. Filip
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
24266. Nanotherapeutics with anthracyclines: methods of determination and quantification of anthracyclines in biological samples
- Creator:
- Koziolova, E., Olga Janoušková, Chytil, P., Martin Studenovský, Kostka, L., and Tomáš Etrych
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, anthracycline, nanocarrier, quantification, 14, and 612
- Language:
- English
- Description:
- Anthracyclines, e.g. doxorubicin, pirarubicin, are widely used as cytostatic agents in the polymer nanotherapeutics designed for the highly effective antitumor therapy with reduced side effects. However, their precise dosage scheme needs to be optimized, which requires an accurate method for their quantification of the cellular level in vitro during nanocarrier development and in body fluids and tissues during testing in vivo. Various methods detecting the anthracycline content in biological samples have already been designed. most of them are highly demanding and they differ in exactness and reproducibility. The cellular uptake and localization is predominantly observed and determined by microscopy techniques, the anthracycline content is usually quantified by chromatographic analysis using fluorescence detection. We reviewed and compared published methods concerning the detection of anthracycline nanocarriers., E. Koziolova, O. Janouskova, P. Chytil, M. Studenovsky, L. Kostka, T. Etrych., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
24267. Naomi and Ruth: the Birth of the Son. In Reference to a Painting of Willem Drost /
- Creator:
- Deurloo, Karel
- Subject:
- Lastman, Pieter,, Drost, Willem,, Starý zákon, malířství, malíři němečtí, světové dějiny 1492-1648, Německo, církevní a náboženské dějiny, and malířství, malíři
- Language:
- English
- Rights:
- unknown
24268. Naplňování politiky podpory veřejného zdraví
- Creator:
- Hamplová, Lidmila, Kotrbová, Kvetoslava, and Velikovský, Zdeněk
- Format:
- 9-11, braille, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, statistics, and TEXT
- Subject:
- veřejné zdravotnictví, zdravotní politika--ekonomika, programy podpory zdraví--ekonomika, and lidé
- Language:
- Czech and English
- Description:
- Národní program zdraví ČR, který byl zahájen v 90. letech na základě formulovaných cílů obnovy a podpory zdraví v rámci tvorby zdravotní politiky, se postupně vytratil. Došlo k poklesu počtu finančních zdrojů a v jeho důsledku také programů. Trend úspor byl realizován dvou fázích. První byla zahájen v souvislosti s tzv. měnovou krizí v roce 1997 a druhá fáze úspor až k nule je patrna v souvislosti se vstupem do EU, jejíž prostředky zjevně umožňují Českým veřejným financím realizovat ještě větší úspory. Otázkou je, proč nebyly evropské prostředky aspoň částečně využity také v rámci Národního programu zdraví ČR?, National Health Programme of the Czech Republic, which was launched in the 90 years on the basis of formulated policy goals of health promotion, gradually disappeared. There has been a decline in financial resources and consequently also the programs. Trend of savings was realized in two phases. The first one was launched in connection with the monetary crisis in 1997 and the second phase to zero savings is evident in the context of EU accession, which allowed in the Czech public finances to realize even greater savings. The question is, why were not at least partly European funds also used within the National Health Programme of the Czech Republic and how was National Health Programme substituted?, MUDr. Lidmila Hamplová Ph.D., doc. MUDr. Květoslava Kotrbová Ph.D., MUDr. Zdeněk Velikovský, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
24269. Napoleon
- Creator:
- Baily, James Thomas Herbert
- Publisher:
- The connoisseur Magazine
- Format:
- print and 126 s. : tb.
- Type:
- model:monograph and TEXT
- Subject:
- Biografie, I., francouzský císař, Napoleon, 1769-1821, panovníci, vojevůdci, 8, and 929
- Language:
- English
- Description:
- James Thomas Herbert Baily ; illustrated with prints from contemporary and other portraits.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
24270. Napoleon and Eastern Europe. = Napoleon a evropský východ /
- Creator:
- Procházka, Jiří
- Subject:
- Napoleon, války napoleonské (1803-1815), zahraniční politika, mezinárodní vztahy, vojenské operace, války, bitvy, světové dějiny 1789-1918, and Francie
- Language:
- English and Czech
- Rights:
- unknown