This essay aims to describe hitherto unknown notes of aesthetics lectures given by August Gottlieb Meißner (1753-1807) at Prague University. It compares these notes (made by a certain Wagner, and deposited in the Wienbibliothek im Rathaus) with notes deposited in Czech libraries, and seeks to determine their place chronologically amongst notes made by others attending Meißner’s lectures over the years. The most important difference in content between the earlier known notes and Wagner’s is Meißner’s negative attitude towards the Schlegel brothers. This attitude slightly alters our existing notion of his views on the relationship between literature and morality. Taken alone, the collections of notes in Czech libraries had led one to conclude that this Prague ordinarius was an ardent libertine, who dared, even at a conservative Austrian university, to push for the autonomy of art, including a thorough split between art and morality, regarding not only works of art, but also, to a certain extent, the artists themselves. By contrast, the Vienna MS as a matter of priority restricts this split to art, and limits it to the higher, moral aims of the artist as citizen. His approach to questions of morality and to the Schlegel brothers demonstrates that while Meißner considered himself part of the liberally enlightened current of contemporaneous literature, which made moving the emotions the central aim of art, he was no longer an adherent of upandcoming Romanticism with its extreme conviction about unlimited authorial liberty, which stemmed from the philosophical Idealism of the times. This attitude to the Schlegel brothers also suggests that Wagner attended Meißner’s lectures in aesthetics and rhetoric in the winter of 1800/1., Tomáš Hlobil., and Obsahuje bibliografické odkazy
Cisplatin is a commonly used chemotherapeutic drug. It is known
for its nephrotoxic side effects with an increased risk of acute
kidney injury. Finding of clinically feasible cisplatin nephrotoxicity
markers is of importance. In our study, we compared neutrophil
gelatinase-associated lipocalin (NGAL) in serum and urine, the
estimated glomerular filtration rate (based on serum cystatin C)
and urine albumin as markers of nephrotoxicity. The study
involved 11 men and 9 women (mean ± SD age 58.2 ± 9.5 years)
with different malignancies treated with cisplatin in four cycles of
chemotherapy (I – IV). Samples 0-4 were taken before,
immediately after, in 3, 6 and 24 hours after administering
chemotherapy. We detected significant increase of ACR in
Sample 2 (p=0.03) and decrease of eGFR in Sample 4 (p=0.03)
up to 24 hours after cisplatin administration in the first
chemotherapy cycle only. When cumulative effect of cisplatin was
assessed, significantly increased values of urine albumin (vs cycle
I) were found in Sample 0 (p=0.00058), 1 (p=0.00256),
2 (p=0.00456), 3 (p=0.00006) and 4 (p=0.00319) in cycles II to
IV. We found a correlation between values of urine NGAL and
urine albumin (r=0.68, p<0.0001). In conclusion, urine albumin
was the only measured marker that consistently and statistically
significantly increased after cisplatin containing chemotherapy
cycles.
Generalizing earlier results about the set of idempotents in a Banach algebra, or of self-adjoint idempotents in a C*-algebra, we announce constructions of nice connecting paths in the connected components of the set of elements in a Banach algebra, or of self-adjoint elements in a C*-algebra, that satisfy a given polynomial equation, without multiple roots. In particular, we prove that in the Banach algebra case every such non-central element lies on a complex line, all of whose points satisfy the given equation. We also formulate open questions., Endre Makai Jr., Jaroslav Zemánek., and Obsahuje seznam literatury