Lidské papilomaviry jsou v centru pozornosti jako původci mnoha benigních i maligních onemocnění ženského genitálu. V posledních desetiletích byl učiněn významný pokrok ve výzkumu v oblasti virové genetiky, etiopatogeneze, prevence a léčby papilomavirových infekcí. Výsledkem jsou informace, které umožnily zavedení nových metod v prevenci a diagnostice cervikálního karcinomu. Tento článek shrnuje aktuální poznatky o infekcích lidskými papilomaviry v gynekologii., Human papillomavirus gained a lot of attention during past years for being the main cause of many benign and malignant diseases of female genital tract. During the last few decades the significant progress in research of genetics, etiopathogenesis, prevention and treatment of papillomavirus infections have been made. These results enable us to implement new methods in the prevention and diagnostics of cervical cancer. This article summarizes current knowledge about human papillomavirus infections in gynecology., Alena Kubečková, Ondřej Kubeček, Jiří Špaček, and Literatura
Parabens are a group of chemicals used as preservatives in the food, cosmetic and pharmaceutical industries. They are known to possess estrogenic effects, and therefore have been classified as endocrine disruptors. In addition to the classical endocrine organs, other tissues have endocrine activity, including adipose tissue. Several chemicals are known to cause obesogenic effects, and parabens are currently being studied in this context. The aim of this study was to investigate the possible connections of paraben exposure and obesity. Blood plasma from 27 healthy women was collected during their menstrual cycle. Basal anthropometric measures, levels of parabens (methylparaben, ethylparaben and propylparaben), adipokines (adiponectin, adipsin, leptin, resistin and visfatin) and hormones affecting energy balance and metabolic health (c-peptide, ghreline, GIP, GLP-1, glucagon, insulin, PAI-1) were measured. A Kolmogorov- Smirnov test showed higher methylparaben and propylparaben levels in women with BMI 25-34.9 compared to those with BMI 18.5-24.9. Plasma levels of methylparaben as well as the sum of parabens were positively associated with the plasma adipsin levels. Negative associations for methylparaben were found for glucagon, leptin and PAI-1. In accordance with other experimental studies we observed important associations of methylparaben and hormones affecting energy balance and metabolic health, indicating its obesogenic potential., L. Kolatorova, M. Sramkova, J. Vitku, J. Vcelak, O. Lischkova, L. Starka, M. Duskova., and Obsahuje bibliografii