Isogeometric analysis is a quickly emerging alternative ot the standard, polynomial-based finite element analysis. It is only the question of time, when it will be implemented into major software packages and will be intensively used by engineering community to the analysis of complex realistic problems. Computational demands of such analyses, that may likely exceed the capacity of a single computerk can be parallel processing requires usuall an appropriate decomposition of the investigated problem to the individual processing units. In the case of he isogeometric analysis, the decomposition corresponds to the spatial partitioning of the underlying spatial discretization. While there are several matured graphs-based decomposers which can be readily applied to the subdivison of finite element meshes, their use in the context of the isogeometric analysis is not straightforward because of a rather complicated construction of the graph corresponding to the computational isogeometric mesh. In this paper, a new technology for the construction of the dual graph of a two-dimensional NURBS-based (non-uniform rational B-spline) isogeometric mesh is introduced. This makes the partitioning of the isogeometric meshes for parallel processing accessible for the standard graph-based partitioning of the isogeometric meshes for parallel processing accessible for the standard graph-based partitioning approaches. and Obsahuje seznam literatury
Expression of parvalbumin (PV) and transient receptor potential vanilloid (TRPV1) receptors in the lumbar dorsal root ganglion neurons (DRG) was evaluated in control animals and in rats after acute carageenan-induced knee joint inflammation. PV is a calcium binding protein that acts as a calcium buffer, affects intracellular calcium homeostasis and may thus influence signal transduction and synaptic transmission. TRPV1 receptors are viewed as molecular integrators of nociceptive stimuli and modulate spinal cord synaptic transmission beside their function in the peripheral nerve endings. In naive rats, 13 % of the L4 DRG neurons had PV immunopositivity (PV+) and 36 % expressed TRPV1 receptors (TRPV1+). The soma of the PV+ neurons was of medium to large size, while the TRPV1 receptors were expressed in small diameter neurons. The co-localization of the PV and TRPV1 immunoreactivity was minimal (0.2 %). There was no significant change in the PV+ (11 %), TRPV1+ (42 %) and PV+TRPV1+ (0.25 %) expression, or shift in the neuronal size distribution 28 h after the unilateral peripheral inflammation, both when compared to controls and when ipsilateral to contralateral sides were evaluated. Thus under the given experimental conditions, no change in somatic TRPV1 receptors and PV expression in L4 DRG neurons was found., G. Zachařová, J. Paleček., and Obsahuje seznam literatury
Pásový opar je vyvolán jedním z lidských herpetických virů. Jde o projev reaktivace viru, ke které dochází nejčastěji u starších osob. Příčinou může být těžké základní onemocnění, ale i přirozený pokles imunity, ke kterému dochází ve stáří. Pásový opar se však může objevit i u dětí a mladých lidí, jejichž imunita je narušena těžkým onemocněním či jeho léčbou., Shingles is caused by one of the human herpetic viruses. It is an expression of reactivation of the virus which mostly occurs in elderly people. Shingles can be caused by a severe underlying illness, as well as by natural decline in immunity brought about by the advancing age. However, herpes zoster can also occur in children or young people whose immunity has been compromised by severe illness or its treatment., and Hana Roháčová