Whole cell patch-clamp recordings from GABAergic cells of thalamic reticular nucleus (RTN) in thalamocortical slices made from postnatal day 6 (P6) to 10 (P10) were used to investigate the pattern of rebound bursts (RBs) triggered by an injection of hyperpolarizing current into RTN cells. The number of RBs in the RTN and the overlying Na+/K+ spikes changed in an agedependent manner. The generation of RBs depended largely on the amplitude of the after-hyperpolarizations (AHPs). RB patterns in response to hyperpolarizing current injection into relay cells were markedly different from RB patterns in RTN cells with an after-depolarization. GABAA receptor antagonist bicuculline methiodide (BMI) changed burst firing patterns, increasing the duration of RB and decreasing the amplitude of AHP in RTN cells. Furthermore, local puffs of NMDA in the presence of BMI induced RBs. K+ channel blocker 4-aminopyridine partially mimicked the effect of BMI on AHPs. The shapes of RBs were altered by a selective CaMKII inhibitor KN-62, but not by an inactive analog KN-04., X. Wang ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
We present a 73 year old female with intractable pruritus and nonspecific cutaneous rash for a period of 9 months. She had recieved symptomatic therapy with no improvement. A complete examination revealed axillary and abdominal lymphadenopathy. A biopsy confirmed the diagnosis of Hodgkins lymphoma with Langerhans cell histiocytosis. She received 5 cycles of chemotherapy with resolution of pruritus and reduction in axillary and abdominal lymphadenopathy. The patient presented 6 months later with relapse and succumbed to the illness. Simultaneous occurrence of Langerhans cell histiocytosis and Hodgkins lymphoma may lead to misdiagnosis. The awareness of such an association is important to make an accurate diagnosis and guide appropriate therapy., Afsha A. Topal, Ram H. Malkani, Ganapathi Bhat, Reshma T. Vishnani, and Literatura 17
Micro-displacement monitoring in Slopy a nd Zbojnícka caves is described. It st arted at the end of 2005 with the use o f verified, stable and sensitive 3D crack gauges TM71 produced by GESTRA Sedloňov. Two gauges were installed in the caves across significant tectonic structures. Registered displacements are pertinent to the last significant earthquake events. The f irst one appeared in March 13, 2006 at Vrbové, M=3.2; and later in August 5-8, 2006, a swarm of 10 quakes M max = 2.2 at Trstín was registered. The results indicated trends of dextral strike-slip displacements across observed fault structures in both of those caves., Miloš Briestenský and Josef Stemberk., and Obsahuje bibliografické odkazy
The paper is focused to the analysis of permanent and epoch-wise GPS networks extending over the region of Slovakia. We considered almost all available GPS data measured in Slovakia and its close surroundings over the period of last 17 years. Our analysis is based on combination of homogenized permanent and epoch-wise network solutions leading to the ITRF2005 related coordinates, velocities and their global covariance matrix. Estimated velocities were further reduced for APKIM2005d plate motion model and submitted to the velocity filtering and smoothing using the least square collocation approach. The obtained homogenized intra-plate velocity field is then used for the surface deformation analysis. The final and partial results of this procedure are discussed in order to extend information about recent regional geo-kinematics of Slovakia., Ján Hefty, Linda Hipmanová, Ľubomíra Gerhátová, Miroslava Igondová and Branislav Droščák., and Obsahuje bibliografii
We present the crustal deformation field in the Penola Strait – Lemaire Channel fault area (West Antarctica), based on the analysis of the 5 seasonal cycles of static GNSS survey. This 5 GNSS campaigns were conducted with approximately a 16-year interval from 2003 to 2019. The analyses indicate that average linear velocities of horizontal movements are multidirectional but no larger than 1 – 2 mm/yr. Average linear velocities of vertical movements are no larger than ±3 mm/yr. In the present work scheme of vertical and horizontal movements has been drawn out. The obtained results correlate well with the movements of the surrounding GNSS stations. Based on the analysis of spatial distribution of the Earth’s surface dilatation velocity the zones of extreme compression and expansion values were revealed. The analyses of spatial distribution of the Earth’s surface total shear velocity indicate that the studied region is horizontally heterogeneous. Based on the analysis of obtained results, a new kinematic model of fault area was developed. The possibility of using static GNSS survey to study recent local geodynamic processes in Antarctica has been demonstrated.