Ventricular assist devices (VAD ) have recently established themselves as an irreplaceable th erapeutic modality of terminal heart failure. Because of the worldwide shortage of donors, ventricular assist devices play a key role in modern heart failure therapy. Some clinical data have revealed the possibility of cardiac recovery during VAD applic ation. On the other hand, both clinical and experiment al studies indicate the risk of the cardiac atrophy development, especially after prolonged mechanical unloading. Little is known about the specific mechanisms governing the unloading-induced cardiac atrophy and about the exact ultrastructural changes in cardiomyocytes, and even less is known about the ways in which possible therapeutical interventions may affect heart at rophy. One aim of this review was to present important aspects of the development of VAD- related cardiac atrophy in humans and we also review the most significant observations linking clinical data and those derived from studies using experimental mo dels. The focus of this article was to review current methods applied to alleviate cardiac atrophy which follows mechanical unloading of the heart. Out of many pharmacological agents studied, only the selective beta2 agonist clenbuterol has been proved to have a significantly beneficial effect on unloading-induced atrophy. Mechanical means of atrophy alleviation also seem to be effective and promising., M. Pokorný ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
Aims of the study were to compare the development of electrocardiographic responses of the ischemia-induced heterogeneities of activation and repolarization in the ventricular myocardium of normal and diabetic animals. Body surface ECGs and unipolar electrograms in 64 epicardial leads were recorded before and during 20 min after the ligation of the left anterior descending artery in diabetic (alloxan model, 4 weeks, n=8) and control (n=8) rabbits. Activation times (ATs), end of repolarization times (RTs) and repolarization durations (activation-recovery intervals, ARIs) were determined in ischemic and periischemic zones. In contrast to the controls, the diabetic rabbits demonstrated the significant prolongation of ATs and shortening of ARIs (P<0.05) during ischemia in the affected region resulting in the development and progressive increase of the ARI and RT gradients across the ischemic zone boundary. The alterations of global and local dispersions of the RTs in diabetics correlated with the Tpeak-Tend interval changes in the limb leads ECGs. In the ischemic conditions, the diabetic animals differed from the controls by the activation delay, significant repolarization duration shortening, and the increase of local repolarization dispersion; the latter could be assessed by the Tpeak-Tend interval measurements in the body surface ECGs., K. A. Sedova, M. A. Vaykshnorayte, A. O. Ovechkin, P. Kneppo, O. G. Bernikova, V. A. Vityazev, J. E. Azarov., and Obsahuje bibliografii
This work deals with the changes of rhetorical education and emotional orders in the second half of the 18th century. The aim of the research is to assess the relations among language education, funtions of medias, anthropological models and expression of emotions on the Threshold of enlightenment. The background of the research shapes the transformation of rhetorical tradition. The research of the broad field of pedagogical, rhetorical and moral discurs is focused on the collegium of Karl Heinrich Seibt., Václav Smyčka., and Obsahuje bibliografické odkazy
We verify functional a posteriori error estimate for obstacle problem proposed by Repin. Simplification into 1D allows for the construction of a nonlinear benchmark for which an exact solution of the obstacle problem can be derived. Quality of a numerical approximation obtained by the finite element method is compared with the exact solution and the error of approximation is bounded from above by a majorant error estimate. The sharpness of the majorant error estimate is discussed.
We verify functional a posteriori error estimates proposed by S. Repin for a class of obstacle problems in two space dimensions. New benchmarks with known analytical solution are constructed based on one dimensional benchmark introduced by P. Harasim and J. Valdman. Numerical approximation of the solution of the obstacle problem is obtained by the finite element method using bilinear elements on a rectangular mesh. Error of the approximation is measured by a functional majorant. The majorant value contains three unknown fields: a gradient field discretized by Raviart-Thomas elements, Lagrange multipliers field discretized by piecewise constant functions and a scalar parameter β. The minimization of the majorant value is realized by an alternate minimization algorithm, whose convergence is discussed. Numerical results validate two estimates, the energy estimate bounding the error of approximation in the energy norm by the difference of energies of discrete and exact solutions and the majorant estimate bounding the difference of energies of discrete and exact solutions by the value of the functional majorant.
The article presents results of the verification calculation of the method for the calculation of natural frequencies and mode shapes of a linear undamped rotationally periodic systems considering the possibility of the elimination of degrees of freedom. As the test example a thin circular plate was chosen. The method can be applied e.g. for the calculation of the natural vibration characteristics of the steam turbine bladed disks. and Obsahuje seznam literatury
At the modernization of the ŠKODA 22 Tr low-floor articulated trolleybus a different type of an articulated joint and a different type of driving axles were used in its construction besides other changes. During test drives with the modernized trolleybus, which were focused on the driving stability of the vehicle, a large roll of the rear section appeared. A suitable structural solution for reducing the rear section roll angle of the modernized trolleybus was the using of a rear section stabilizer bar. The stabilizer effect on dynamic properties of the vehicle and a suitable bar diameter were determined on the basis of the results of the computer simulations with the trolleybus multibody models. The text drives focused on the vehicle driving stability were performed again with the loaded real trolleybus, in the structure of which the designed rear section stabilizer bar was applied. On the basis of computer simulations of the test drives with the trolleybus multibody models the correctness of the experimantal-simulation approach used for the stabilizer bar structural design was verified. and Obsahuje seznam literatury
Vermiculite in its macroscopic form occurs in the Archaean supracrustal rocks exposed towards east of Sargur supracrustal complex in Karnataka state. The present study forms the first detailed work on the occurrence of vermiculite associated with the ultramafic rocks in the Agasthyapura, which lies in the long. 76° 50’ 658” and lat. 12° 15’ 976”. Petrography, X-ray diffraction, FTIR, DTA&TGA, SEM, fluid inclusion and electron probe analyses are presented in this contribution study. The probable origin of vermiculite from biotite through hydrobiotite is discussed., Kikkeri N. Prakash Narasimha, Honnaiah Ramalingaiah, Karel Melka, K. Krishnaveni, Pinnelli S. R. Prasad, Chikkamadaiah Krishnaiah, Katihalli S. Jayappa and Atni V. Ganesha., and Obsahuje bibliografické odkazy