Stroke is despite of progressive improvements in treatment and
reperfusion strategies one of the most devastating human
pathology. However, as quality of acute health care improves and
more people survive ischemic attack, healthcare specialists have
to solve new challenges to preserve reasonable quality of life to
these patients. Thus, novel approaches which prevents
comorbidities of stroke and improve quality of life of stroke
survivors in general has to be developed and experimentally
tested. The aim of the present paper was to establish reliable rat
model of middle cerebral occlusion and set of methods allowing
selection of animals suitable for long-term experiments. We have
compared mortality rates, cerebral blood flow and extension of
ischemic lesion induced by intraluminal filament in three widely
used outbred rat strains. We have additionally used an animal
18F-DG PET scans to verify its reliability in noninvasive detection
of ischemic infarct in acute period (24 h after MCAO) for selecting
animals eligible for long survival experiments. Our data clearly
indicates that high variability between rat strains might
negatively influence stroke induction by intraluminal thread
occlusion of middle cerebral artery. Most reliable outbred rat
strain in our hands was Sprague-Dawley where maximal
reduction of cerebral blood flow and extensive ischemic lesion
was observed. Contrary, Wistar rats exhibited higher mortality
and Long-Evans rats significantly smaller or no ischemic region in
comparison to Sprague-Dawley. Additionally, we have confirmed
a positron emission tomography with 18F-fluorodeoxyglucose as
suitable method to assess extension of ischemic region in acute
period after the experimental arterial occlusion in rats.
A basic physical experimental research of lateral passive pressure is in progress at the Institute of Theoretical and Applied Mechanics. The research is composed of three doubles of the same experiments with three basic retaining wall movements: rotations about the toe or top and translative motion. A double of the same experiments E5/0,1 and E6/0,1 with passive pressure and pressure at rest during wall rotation about the toe was carried out in 1st half 2012 and the 2nd one (E6/0,1) was finished in the early 2013. Both experiments together should prove a real behaviour of non-cohesive mass acting on moving wall. The behaviout appears distinct from a theory of EUROCODE 7-1 contemporaneously used. Each of experimets has brought a huge data quantity. The paper shows strains of both masses, i.e. deformations and slip surfaces of the experimental sandy masses. and Obsahuje seznam literatury
This work presents the procedure of a computational model of pathological hip joint allowing a simple modification of individual parts of the model according to the planned course of femoral and pelvic osteotomy. Both presented models were subjected to strain-stress analysis by a finite element method using the ANSYS program system. The obtained results are compared with physiological hip joint results and the feasibility of planned osteotomy is evaluated based on selected mechanical parameters. The conclusions are consulted with surgeons and possible corelations with clinical results are searched for. and Obsahuje seznam literatury
Nad schodištěm, ve vestibulu budovy, dvě bronzové plastiky. Vlevo mladá žena v dlouhé říze se snopem obilí v levici, v pravé ruce drží ovoce (alegorie Zemědělství nebo Úrody). Vpravo muž v dlouhé říze, opírá se o rýč (Orba?).