Článek se zabývá dosavadním stavem bádání v oblasti dějin ekonomické vědy a činnosti československých ekonomů v období socialismu. Podává přehled o základních příspěvcích k tomuto tématu od počátku devadesátých let jak domácího, tak zahraničního původu. Detailněji se pak věnuje pracím Johanny Bockmanové, Jiřího Suka a Gila Eyala, zmiňuje taktéž nejnovější výzkumné projekty, které se tímto tématem zabývají. Závěrem autor nabízí přehled dostupných pramenů (archivních dokumentů i publikovaných pamětí), kterých lze využít k dalšímu výzkumu., The article examines the current state of research in the field of the history of economic sciences and activities of Czechoslovak economists in the era of socialism. It provides an overview of basic contributions, both domestic and foreign, on this topic since the 1990s, examining works of Johanna Bockman, Jiří Suk and Gil Eyal in a greater detail. It also mentions the latest research projects concerning this topic. In the end, the author offers a list of available sources (archival documents and published memoirs) which can be used in future research., Václav Rameš., and Obsahuje bibliografii a bibliografické odkazy
(Pro)renin receptor (PRR) contributes to regulating many physiological and pathological processes; however, the role of PRR-mediated signaling pathways in myocardial ischemia/reperfusion injury (IRI) remains unclear. In this study, we used an in vitro model of hypoxia/reoxygenation (H/R) to mimic IRI and carried out PRR knockdown by siRNA and PRR overexpression using cDNA in H9c2 cells. Cell proliferation activity was examined by MTT and Cell Counting Kit-8 (CCK-8) assays. Apoptosis-related factors, autophagy markers and β-catenin pathway activity were assessed by real-time PCR and western blotting. After 24 h of hypoxia followed by 2 h of reoxygenation, the expression levels of PRR, LC3B-I/II, Beclin1, cleaved caspase-3, cleaved caspase-9 and Bax were upregulated, suggesting that apoptosis and autophagy were increased in H9c2 cells. Contrary to the effects of PRR downregulation, the overexpression of PRR inhibited proliferation, induced apoptosis, increased the expression of pro-apoptotic factors and autophagy markers, and promoted activation of the β-catenin pathway. Furthermore, all these effects were reversed by treatment with the β-catenin antagonist DKK-1. Thus, we concluded that PRR activation can trigger H/R-induced apoptosis and autophagy in H9c2 cells through the β-catenin signaling pathway, which may provide new therapeutic targets for the prevention and treatment of myocardial IRI.
Let $\Lambda=\left(\begin{smallmatrix} A&M 0&B \end{smallmatrix}\right)$ be an Artin algebra. In view of the characterization of finitely generated Gorenstein injective $\Lambda$-modules under the condition that $M$ is a cocompatible $(A,B)$-bimodule, we establish a recollement of the stable category $\overline{\rm Ginj(\Lambda)}$. We also determine all strongly complete injective resolutions and all strongly Gorenstein injective modules over $\Lambda$., Chao Wang, Xiaoyan Yang., and Obsahuje bibliografii