Brain Awareness Week is a series of events held around the world to increase public awareness of the brain. Top Czech scientists attracted more then 1,300 students with lectures as part of the annual Brain Awareness Week that took place in the administration building of the Czech Academy of Sciences extending from 10-13 March 2008. and Gabriela Adámková.
Carnosine (CARN) is an anti-glycating agent able to quench superoxide, and to neutralize 4-hydroxynonenal. Trolox-carnosine (CARN-T) was synthesized because of its resistance against degradation and to improve CARN antioxidant capacity. We evaluated the impact of trolox (TRO), CARN and its derivative CARN-T on oxidative stress (OS) in brain during rat adjuvant arthritis (AA). The experiments were done on healthy, control arthritic and arthritic animals with administration of CARN 150 mg/kg b.w., TRO 41 mg/kg b.w. and CARN-T 75 mg/kg b.w. in a daily dose during 28 days. Antioxidants did not affect the body weight on day 14, but on day 28 TRO enhanced the weight reduction. On day 14 and 28 CARN-T and TRO reduced arthritic score. IL-1beta, MCP-1 and MMP-9 were measured in plasma on day 14. MCP-1 was decreased by CARN-T and TRO. All antioxidants reduced IL-1beta and MMP-9 levels. Malondialdehyde, 4-hydroxynonenal and protein carbonyls were increased in brain. CARN, CARN-T and TRO prevented higher lipid and protein oxidation in brain. CARN and CARN-T caused no weight reduction like TRO that has an advantage in inflammatory arthritis. Moreover the antioxidants administered had a similar therapeutic effects on arthritic score, markers of inflammation in plasma and OS in brain., S. Poništ, L. Slovák, V. Kuncírová, T. Fedorova, A. Logvinenko, O. Muzychuk, D. Mihalová, K. Bauerová., and Obsahuje bibliografii
Brain Awareness Week is a series of global events held in many parts of the world to increase public awareness of the brain. Every March BAW brings together the efforts of universities, hospitals, patient groups, government associations worldwide in a week-long commemoration of the brain. Founded and coordinated by the Dana Alliance for Brain Initiatives and the European Dana Alliance for the Brain, BAW is observing its fifteenth anniversary campaign in 2010. More than 1,000 students heard lectures by top Czech scientists as part of the annual Brain Awareness Week that took place in the administration building of the Academy of Sciences of the Czech Republic 15-21 March 2010. and Gabriela Adámková.
European Brain Awareness Week, iniciated by the European Dana Alliance for the Brain (EDAB) organization, has been arranged in the Czech Republic by the Press Department of the ASCR, as it has already fot nine years. In March 2007, 11 lectures of the best Czech specialists were presented to high-school students and the public. and Gabriela Štefániková.