Background: Obstetric complications developing at antiphospholipid syndrome are serious medical-social problem. Seeking of the treatment methods sets conditions for urgency of the article reviewed. Enzyme preparations are widely applied for treatment of women with fecundity disorder and hemorheology changes. Research objective was in clinico-laboratorial evaluation of Serrata drug impact in antiphospholipid syndrome in women with reproductive losses of Andijan state. Methods: Data of 43 women in the non-pregnancy state with reproductive losses (RL) in past history with revealed APS had been studied by us. Results: Thus, conducted therapy with Serrata was conductive to haemostasis. Conducted researches confirm the safety of application., Gulnoza Maniyozova, Habiba Negmatshaeva, Ozoda Yuldasheva, Gulnoza Turaeva, Dilfura Parpieva, and Literatura
Tato pilotní studie je zaměřena na parametry CT perfuze (cerebral blood flow, cerebral blood volume a permeability surface area) a multifázické CT angiografie (lokalizace trombu, stav leptomeningeálních kolaterál a morfologii durálních splavů) v predikci rozvoje maligního mozkového edému u pacientů s akutním uzávěrem v přední mozkové cirkulaci. Analyzováni byli pacienti z prospektivní multicentrické studie PROVE-IT (Precise and Rapid assessment of collaterals using multiphase CTA in the triage of patients with acute ischemic stroke for IV or IA Therapy; n = 200). Sledovaným cílovým parametrem vývoje edému byl posun středočárových struktur na kontrolním CT/MR po 24–32 hod. Do analýzy bylo zahrnuto pět pacientů s posunem ≥ 5 mm a pět kontrol, byly srovnány demografické i radiologické údaje. Nejvyšší senzitivita a specificita pro rozvoj klinicky závažného středočárového posunu byla pro CBV < 1,76 ml/min/100 g pro ischemické teritorium. Hodnocení perfuzních parametrů v kompletním teritoriu ischemie neprokázalo signifikantní rozdíl., We explore the predictive value of CT perfusion parameters (permeability surface area, cerebral blood flow, cerebral blood volume) and multiphase CT angiography (clot localization, leptomeningeal collaterals and dural sinuses morphology) in the development of malignant brain oedema in patients with acute proximal occlusion of the middle cerebral artery. Patients from the multicentre prospective study PROVE-IT (Precise and Rapid assessment of collaterals using multi-phase CTA in the triage of patients with acute ischemic stroke for IV or IA Therapy; n = 200) were analysed. Primary outcome was evaluated by midline shift ≥ 5 mm on a follow-up CT/MRI. A CBV threshold of 1.76 ml/100 g had the highest sensitivity and specificity of for the midline shift. There was no significant difference between the two groups in analysed CT perfusion parameters calculated for the entire ischemic region. Key words: acute ischemic stroke – brain oedema – CT perfusion – CTA angiography – dural sinuses The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers., and O. Volný, P. Cimflová, C. D. D’esterre