The study newly identifies a woman depicted in relief on a sandstone tympanum, walled-in secondarily in building Reg. No. 72 in Tišnov in Moravia. The tympanum can be assigned to the second half of the 1230s or to the 1240s, with its vegetable décor matching in detail a similar motif on the well-known western portal of the church of the Cistercian convent at Porta Coeli at Tišnov. Characteristic features establish the woman as being Saint Elisabeth of Thuringia (1207-1231), a major person in European spirituality of the 13th C., canonised in 1235. This is, then, evidence of very early reception of the new saint in the Czech Lands, clearly inspired by tight dynastic ties: the Czech queen - widow Constance of Hungary, who founded the Porta Coeli convent in 1232, was Elisabeth’s aunt by bloodline. The sculpture is at the same time one of the very oldest artistic depiction of Saint Elisabeth in the European context, with typical accent on the saint’s tight ties to the ideals of Saint Francis of Assisi. Nevertheless, we do not yet know the original location of the tympanum, but apart from the site of Porta Coeli itself the parish church of Saint Wenceslas at Tišnov does fall into consideration. and Jiří Doležel.
Vasoactive intestinal peptide (VIP) is a neuropeptide released from the autonomic nerves exerting multiple antiinflammatory effects. The aim of the present study was to investigate the impact of severe sepsis and hemofiltration in two settings on plasma and tissue concentrations of VIP in a porcine model of sepsis. Thirty-two pigs were di vided into 5 groups: 1) control group; 2) control group with conventional hemofiltration; 3) septic group; 4) septic group with conventional hemofiltration; 5) septic group with high-volume hemofiltration. Sepsis induced by faecal peritonitis continued for 22 hours. Hemofiltration was applied for the last 10 hours. Hemodynamic, inflammatory and oxidative stress parameters (heart rate, mean arterial pressure, cardiac output, systemic vascular resistance, plasma concentrations of tumor necrosis factor- α , interleukin-6, thiobarbituric acid reactive species, nitrate + nitrite, asymmetric dimethylarginine) and the systemic VIP concentrations were measured before faeces inoculation and at 12 and 22 hours of peritonitis. VIP tissue levels were determined in the left ventricle, mesenteric and coronary arteries. Sepsis induced significant increases in VIP concentrations in the plasma and mesenteric artery, but it decreased peptide levels in the coronary artery. Hemofiltration in both settings reduced concentrations of VIP in the mesenteric artery. In severe sepsis, VIP seems to be rapidly depleted from the coronary artery and, on the other hand, upregulated in the mesenteric artery. Hemofiltration in both settings has a tendency to drain away these upregulated tissue stores which could result in the limited secretory capacity of the peptide., J. Kuncová ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy