In the paper, authors are concerned with a hydraulic behaviour of bridges at high water stages and especially with the so far almost unregarded case when bridge roadway is overflowing. There are mentioned their own solutions for the estimation of the backwater by the bridge besides assessment of the applicability of some used relations. These new solutions were derived on the basis of research on the physical model at hydraulic laboratory of the Faculty of Civil Engineering of the Czech Technical University in Prague in 2001 and 2002. and Studie se zabývá hydraulickým chováním mostů při vysokých vodních stavech a zejména dosud téměř opomíjeným případem, kdy dochází k přelévání mostovky. Vedle posouzení aplikovatelnosti některých používaných vztahů jsou zde také uvedena vlastní řešení pro stanovení vzdutí mostem. Tato nová řešení byla odvozena na základě výzkumu na fyzikálním modelu prováděného v letech 2001 a 2002 v hydraulické laboratoři Fakulty stavební ČVUT v Praze.
Cardiac surgery is inseparably linked to the activation of innate immunity cells recognizing danger signals of both endogenous and exogenous origin via pattern recognition receptors such as TLR receptors. Therefore, we followed by flow cytometry TLR2 and TLR4 expression on blood monocytes and granulocytes of patients who underwent coronary artery bypass grafting using beating heart surgery (off-pump, n = 34), with use of standard cardiopulmonary bypass (CPB), (on-pump, n = 30), and miniinvasive CPB (mini on-pump, n = 25), respectively, before, during surgery, and up to 7th postoperative day. TLR2 and TLR4 expression both on monocytes and granulocytes was significantly diminished already at the end of CPB being highly significantly decreased at the end of surgery in all patients' groups. TLR2 and TLR4 expression reached preoperative value at the 1st postoperative day being significantly higher at the 3rd postoperative day. Using intracellular staining we found the peak of TLR2 and TLR4 expression inside of monocytes and granulocytes at the first postoperative day in a subgroup of on-pump patients. In conclusion, TLR2 and TLR4 expression is significantly modulated in patients undergoing coronary artery bypass grafting as a part of adaptive homeostatic mechanisms induced by major surgery. The very surgical trauma is responsible for TLR2 and TLR4 modulation. Surprisingly, cardiopulmonary bypass itself was little contributing to the modulation of TLR2 and TLR4 expression. and J. Krejsek, M. Kolácková, J. Mand'ák, P. Kunes, Z. Holubcová, D. Holmannová, M. AbuAttieh, C. Andrýs