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362. Projekt Jana Purkyně na vybudování fyziologického ústavu na pražské univerzitě /
- Creator:
- Havránek, Jan,
- Type:
- text, studie, and korespondence
- Subject:
- Vysoké školy, Purkyně, Jan Evangelista,, Thun-Hohenstein, Leopold Lev,, fyziologie, lékařství, fakulty lékařské, Univerzita Karlova, české země 1848-1914, vědy o živé přírodě, and dějiny vědeckých institucí, vysokých škol
- Language:
- Czech and German
- Rights:
- unknown
363. Prophylactic inhalation of L-alanyl-L-glutamine enhances heat shock protein 72 and attenuates endotoxin-induced lung injury in rats
- Creator:
- Chuang, I.-C., Huang, M.-S., Huang, L.-J., Chou, S.-H., Tsai, T.-N., Chen, Y.-C., and Yang, R.-C.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, glutamine, heat shock protein 72, acute lung injury, aerosol therapy, 14, and 612
- Language:
- English
- Description:
- Studies have demonstrated that heat shock protein 70 (HSP70) plays an important role in the protection of stressed organisms. The development of strategies for enhancing HSPs expression may provide novel means of minimizing inflammatory lung conditions, such as acute lung injury. This study aimed to examine the effect of L-alanyl-L-glutamine (GLN) inhalation in enhancing pulmonary HSP72 (inducible HSP70) expression and attenuating lung damage in a model of acute lung injury induced by Lipopolysaccharide (LPS) inhalation. The experimental rats were randomly assigned to one of four experimental groups: (1) NS: saline inhalation; (2) NS-LPS: pretreatment by saline inhalation 12 h before LPS inhalation; (3) GLN: glutamine inhalation; (4) GLN-LPS: pretreatment by glutamine inhalation 12 h before LPS inhalation. The results show that GLN compared with saline administration, led to significant increase in lung HSP72 both in non LPS-treated rats and LPS-treated rats. In LPStreated rats, pretreatment by GLN inhalation produced less lung injury as evidenced by the decrease in lung injury score and dramatic decrease in lactate dehydrogenase (LDH) activity and polymorphonuclear leukocyte cell differentiation counts (PMN %) in the bronchoalveolar lavage fluid. The study indicates that prophylactic glutamine inhalation associated with the enhancement of HSP72 synthesis attenuates tissue damage in experimental lung injury., I.-C. Chuang, M.-S. Huang, L.-J. Huang, S.-H. Chou, T.-N. Tsai, Y.-C. Chen, R.-C. Yang., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
364. Protection against ischemia-induced ventricular arrhythmias and myocardial dysfunction conferred by preconditioning in the rat heart: Involvement of mitochondrial K ATP channels and reactive oxygen species
- Creator:
- Jana Matejíková, Jarmila Kucharská, Mária Pintérová, Dezider Pancza, and Ravingerová, T.
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, srdeční arytmie, ischemická choroba srdeční, physiology, cardiac arrhythmia, ischemic heart disease, preconditioning, mito K ATP channels, rat heart, 14, and 612
- Language:
- English
- Description:
- a1_Ischemic preconditioning (I-PC) induced by brief episodes of ischemia and reperfusion (I/R) protects the heart against sustained I/R. Although activation of mitochondrial K ATP channels (mitoK ATP) interacting with reactive oxygen species (ROS) has been proposed as a key event in this process, their role in the antiarrhythmic effect is not clear. This study was designed: 1) to investigate the involvement of mito K ATP opening in the effect of I-PC (1 cycle of I/R, 5 min each) on ventricular arrhythmias during test ischemia (TI, 30-min LAD coronary artery occlusion) in Langendorff-perfused rat hearts and subsequent postischemic contractile dysfunction, and 2) to characterize potential mechanisms of protection confer red by I-PC and pharmacological PC induced by mito K ATP opener diazoxide (DZX), with particular regards to the modulation of ROS generation. Lipid peroxidation (an indicator of increased ROS production) was determined by measurement of myocardial concentration of conjugated dienes (CD) and thiobarbituric acid reactive substances (TBARS) in non-ischemic controls, non-preconditi oned and preconditioned hearts exposed to TI, I-PC alone, as well as after pretreatment with DZX, mito K ATP blocker 5-hydroxydecanoate (5-HD) and antioxidant N-acetylcysteine (NAC)., a2_Total number of ventricular premature beats (VPB) that occurred in the control hearts (518±71) was significantly (P<0.05) reduced by I-PC (195±40), NAC (290±56) and DZX (168±22). I-PC and NAC suppressed an increase in CD and TBARS caused by ischemia indicating lower production of ROS. On the other hand, I-PC and DZX themselves moderately enhanced ROS generation, prior to TI. Bracketing of I-PC with 5-HD suppressed both, ROS production during PC and its cardioprotective effect. In conclusion, potential mechanisms of protection conferred by mito K ATP opening in the rat heart might involve a temporal increase in ROS production in the preconditioning phase triggering changes in the pro/antioxidant balance in the myocardium and attenuating ROS production during subsequent prolonged ischemia., J. Matejíková ... [et al.]., and Obsahuje seznam literatury
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
365. Purkyňova koncepce výuky fyziologie /
- Creator:
- Pokorný, Jaroslav,
- Type:
- text and studie
- Subject:
- Lékařské vědy. Lékařství, Purkyně, Jan Evangelista,, fyziologie, lékařství, výuka lékařství, ústavy lékařské, české země 1792-1918, dějiny zdravotnictví, lékaři, and školství, pedagogika, učitelé, péče o mládež
- Language:
- Czech
- Rights:
- unknown
366. Purkyňovy objevy jako základ moderního neurovědního výzkumu /
- Creator:
- Syková, Eva,
- Type:
- text and studie
- Subject:
- Lékařské vědy. Lékařství, Purkyně, Jan Evangelista,, lékařství, fyziologie, neurologie, české země 1792-1918, and dějiny zdravotnictví, lékaři
- Language:
- Czech
- Rights:
- unknown
367. Purkyňovy studie rovnovážné funkce a sluchu /
- Creator:
- Syka, Josef,
- Type:
- text and studie
- Subject:
- Lékařské vědy. Lékařství, Purkyně, Jan Evangelista,, lékařství, vnímání prostoru, fyziologie, neurologie, české země 1792-1918, and dějiny zdravotnictví, lékaři
- Language:
- Czech
- Rights:
- unknown
368. Quaternary benzo[c]phenanthridine alkaloids as inhibitors of dipeptidyl peptidase IV-like activity bearing enzymes in human blood plasma and glioma cell lines
- Creator:
- Aleksi Šedo, Radek Malík, Jaroslav Vičar, Šimánek, V., and Jitka Ulrichová
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, fagaronine, sanguinarine, chelerythrine, macleya cordata, dipeptidyl peptidase IV, attractin, 14, and 612
- Language:
- English
- Description:
- Quaternary benzo[c]phenanthridine alkaloids (QBA), fagaronine (FA), sanguinarine (SA), chelerythrine (CHE) and the QBA extract from Macleya cordata (EX) exerted differential inhibitory effect on the hydrolytic activity of particular dipeptidyl peptidase (DPP)-like enzyme isolated from human blood plasma and from human and rat glioma cell lines. The low-MW form of DPP-IV-like enzyme activity, corresponding most probably to DPP-8, observed only in glioma cells but not in human plasma, was inhibited preferentially by SA, CHE and EX, and only slightly by FA. The alkaloid inhibitory effect was concentration-dependent in the range 25-150 M and directly pH-related. In addition, a subtle but consistent inhibition of the intermediate-MW form of DPP-IV-like enzyme activity, ascribed to DPP-IV/CD26, observed only in human plasma and of the attractin (high-MW form of DPP-IV-like enzyme activity, expressed in U87 glioma cells) by the studied alkaloids was observed. We conclude that some of the QBA biological effects could be determined by tissue and cell type specific dipeptidyl peptidase IV-like molecules expression pattern., A. Šedo, R. Malík, J. Vičar, V. Šimánek, J. Ulrichová., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
369. Radiofrequency electromagnetic field affects heart rate variability in rabbits
- Creator:
- Míšek, Jakub, Veterník, Marcel, Tonhajzerová, Ingrid, Jakušová, Viera, Janousek, Ladislav, and Jakuš, Ján
- Format:
- počítač and online zdroj
- Type:
- model:article and TEXT
- Subject:
- mobilní komunikace, králíci, fyziologie, mobile communication, rabbits, physiology, cardiac autonomic regulation, cell phone, radiofrequency electromagnetic exposure, 14, and 612
- Language:
- English
- Description:
- The aim of this study was to assess the effects of radiofrequency electromagnetic field (RF EMF) on heart rate variability (HRV) in rabbits with intensity slightly exceeding the limits for occupations. Totally 21 New Zealand white rabbits divided into two groups were used in this double-blind study. The first group of animals without general anesthesia was subjected to HRV examination under exposure to a device generated RF EMF source (frequency 1788 MHz, intensity 160 V/m, lasting 150 min.). The second group (premedications + α chloralose mg/kg) underwent the same protocol under the exposure to the real RF EMF signal from the base stations of mobile providers (frequency range 1805 - 1870 MHz - corresponding to the downlink signal of Slovak mobile providers, 160 V/m, 150 min., respectively). Individual 5-min records were used to analyze the HRV parameters: heart rate and root Mean Square of the Successive Differences (rMSSD) for time domain analysis and spectral powers in the low (LF-VFS) and high frequency (HF-VFS) bands for frequency domain analysis. Our study revealed the increased in HRV parameters (HF-HRV, rMSSD) associated with lower heart rate indicating increased cardiac vagal control under the exposure to RF EMF in experimental methods., Jakub Misek, Marcel Veterník, Ingrid Tonhajzerova, Viera Jakusova, Ladislav Janousek, Jan Jakus., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
370. Rapid but not slow spinal cord compression elicits neurogenic pulmonary edema in the rat
- Creator:
- Jiří Šedý, Josef Zicha, Jaroslav Kuneš, Pavla Jendelová, and Eva Syková
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, edém, poranění míchy, krevní tlak, pulz (lékařství), krysa obecná, physiology, edema, spinal cord injuries, blood pressure, pulse, Rattus rattus, neurogenic pulmonary edema, 14, and 612
- Language:
- English
- Description:
- The development of neurogenic pulmonary edema (NPE) can be elicited by an immediate epidural balloon compression of the thoracic spinal cord. To evaluate whether a slower balloon inflation could prevent NPE development, we examined the extent of NPE in animals lesioned with a rapid (5 μl - 5 μl - 5 μl) or slow rate (3 μl - 2 μl - 2 μl - 2 μl - 2 μl - 2 μl - 2 μl) of balloon inflation. These groups were compared with the NPE model (immediate inflation to 15 μl) and with healthy controls. Slow balloon inflation prevented NPE development, whereas the pulmonary index and histology revealed a massive pulmonary edema in the group with a rapid rate of balloon inflation. Pulmonary edema was preceded by a considerable decrease in heart rate during the inflation procedure. Moreover, rapid inflation of balloon in spinal channel to either 5 μl or 10 μl did not cause NPE. Thus, a slow rate of balloon inflation in the thoracic epidural space prevents the development of neurogenic pulmonary edema, most likely due to the better adaptation of the organism to acute circulatory changes (rapid elevation of systemic blood pressure accompanied by profound heart rate reduction) during the longer balloon inflation period. It should be noted that spinal cord transection at the same level did not cause neurogenic pulmonary edema., J. Šedý ... [et al.]., and Obsahuje seznam literatury
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public