The paper is describing the current state of intermediation services in CZ NUTZ 2 Region Prague, based on results of ongoing SUPER-SME Project of FP6. It is possible to identify an important role of itnermediaries in research, development, and innovation activities. The intermediation aims at otpimizing supply of scientific and technological services, with demad of RTDI companies and organizations or any other actors using or interested in using these services, e.g. national or regional stakeholders. S&T intermediary is defined as a public, private, or public/private (non-profit) instition with a mission of optimizing interface between supply of sicentific and technological services and demand of an enterpirse, groups of enterpirses, or any institution in this respect. Universities, research centrers, private companies, or technology transfer centers can play a role of S&T intermediary., Adolf Filáček., and Obsahuje seznam literatury