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1. Effect of collagen I gel on apoptosis of rat hepatic stellate cells

Creator:
Bittnerová, Lenka, Jiroutová, Alena, Rudolf, Emil, Řezáčová, Martina, and Kanta, Jiří
Format:
print, text, and regular print
Type:
model:article, article, Text, časopisecké články, práce podpořená grantem, and TEXT
Subject:
zvířata, apoptóza--účinky léků, chlorid uhličitý, buněčné kultury, kolagen typu I--farmakologie, cykloheximid, cytochalasin D, modely nemocí na zvířatech, gliotoxin, jaterní hvězdicovité buňky--účinky léků--patologie, jaterní cirhóza--patologie, mužské pohlaví, krysy, and potkani Sprague-Dawley
Language:
English
Description:
Activated hepatic stellate cells (HSC) are a major source offibrous proteins in cirrhotic liver. Inducing or accelerating their apoptosis is a potential way of liver fibrosis treatment. Extracellular matrix (ECM) surrounding cells in tissue affects their differentiation, migration, proliferation and function. Type I collagen is the main ECM component in fibrotic liver. We have examined how this protein modifies apoptosis of normal rat HSC induced by gliotoxin, cycloheximide and cytochalasin D in vitro and spontaneous apoptosis of HSC isolated from CCl4-damaged liver. We have found that type I collagen gel enhances HSC apoptosis regardless of the agent triggering this process. and L. Bittnerová, A. Jiroutová, E. Rudolf, M. Rezácová, J. Kanta
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

2. Liver mitochondrial enzyme system in the dynamics of experimental leukemia

Creator:
Kasymova, Gulmira and Zaribbaev, Ulugbek
Format:
braille, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, statistics, and TEXT
Subject:
modely nemocí na zvířatech, krysy, výzkumný projekt, leukemie--chemicky indukované, injekce subkutánní, nebezpečné látky--škodlivé účinky, játra--imunologie--účinky léků, mitochondrie jaterní--enzymologie--imunologie--účinky léků, časové faktory, and zvířata
Language:
English
Description:
In rats with leukemia activity of liver mitochondrial enzymes are decreased at 6 months. Later, we noted compensatory activation of complexes II and III of the respiratory chain and transition to decompensation stage by final deadline. The activity of complex IV of the respiratory chain remains high. These changes result from increased lipid peroxidation and decreased activity of antioxidant protection enzymes., Gulmira Kasymova, Ulugbek Zaribbaev, and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3. Pistacia terebinthus coffee protects against thioacetamide-induced liver injury in rats

Creator:
Bahcecioglu, Ibrahim Halil, Ispiroglu, Murat, Tuzcu, Mehmet, Orhan, Cemal, Ulas, Mustafa, Demirel, Ulvi, Yalniz, Mehmet, Özercan, Ibrahim H., Ilhan, Necip, and Sahin, Kazim
Format:
print, text, and regular print
Type:
model:article, article, Text, časopisecké články, and TEXT
Subject:
zvířata, antioxidancia--farmakologie, modely nemocí na zvířatech, zánět--farmakoterapie, játra--účinky léků--metabolismus--patologie, experimentální cirhóza jater--chemicky indukované--metabolismus--patofyziologie--prevence a kontrola, mužské pohlaví, noxy--toxicita, oxidační stres--účinky léků, Pistacia, krysy, potkani Sprague-Dawley, Teas, Herbal, thioacetamid--toxicita, transformující růstový faktor beta--metabolismus, výsledek terapie, and triterpeny--farmakologie
Language:
English
Description:
AIM/BACKGROUND: Pistacia terebinthus is used as a coffee substitute in the East and Southern Anatolia regions of Turkey. It contains unsaturated fatty acids, tocopherols, polyphenols and carotenoids. P. terebinthus has anti-inflammatory and potential antioxidant activity. In this study we evaluated the protective effects of P. terebinthus coffee (PTC) on thioacetamide (TAA)-induced liver injury in rats. MATERIALS AND METHODS: Twenty-eight male Sprague-Dawley rats were equally randomized into four groups. Chronic liver injury was induced with TAA (100 mg/kg i.p. three times weekly). The first group of rats served as control and received only tap water (G1), and the remaining groups of rats received PTC, p.o (G2); TAA (G3); TAA plus PTC, p.o (G4), respectively. RESULTS: After 8 weeks, PTC intake significantly reduced fibrosis/inflammation scores (p PTC intake reduced transforming growth factor beta (TGF-β) concentrations in the liver (p PTC intake. DISCUSSION AND CONCLUSION: PTC intake provided beneficial effects against TAA-induced liver injury in rats. PTC probably suppresses the proinflammatory cytokines through NF-κB signaling pathway. and I. H. Bahcecioglu, M. Ispiroglu, M. Tuzcu, C. Orhan, M. Ulas, U. Demirel, M. Yalniz, I. H. Özercan, N. Ilhan, K. Sahin
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public