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2. Bilateral oophorectomy may have an unfavorable effect on glucose metabolism compared with natural menopause

Creator:
Magdaléna Lejsková, Piťha, J., Adámková, S., Ondřej Auzký, Tomáš Adámek, Eva Babková, Věra Lánská, and Štefan Alušík
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, menopauza, menopause, fasting glucose, fasting insulin, oophorectomy, surgical menopause, 14, and 612
Language:
English
Description:
The incidence of diabetes mellitus is rising worldwide. The aim of this prospective epidemiological study was to compare the effects of natural and surgical menopause on parameters of glucose metabolism. In a group of 587 repeatedly examined women, with a baseline age of 45-55 years, the following subgroups of women were separated: those after bilateral oophorectomy (BO, n=37) and those in natural menopause (NAT, n=380) including women menopausal already at baseline (POST, n=89). The study parameters including glycemia, insulinemia, HOMA-IR and betacell function using HOMA-β were determined at baseline and 6 years later. Over the study period, there was a marked rise in prediabetic and diabetic values of fasting glycemia; the percentage of women with diabetic values increased in the NAT (from 0.8 % to 3.9 %) and POST (from 2.2 % to 9.0 %) subgroups, with the highest prevalence in the BO subgroup (from 8.1 % to 10.8 %). While, among women with non-diabetic fasting glycemia, an increase in fasting glycemia was observed in all study subgroups, it was more marked in the BO subgroup than in the NAT and POST ones (p=0.02 both). This difference between NAT and BO was also found in the long-term trend of development of glycemia in non-diabetic women (p=0.014). Compared with natural menopause, bilateral oophorectomy may have an adverse effect on glucose metabolism., M. Lejsková, J. Piťha, S. Adámková, O. Auzký, T. Adámek, E. Babková, V. Lánská, Š. Alušík., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3. Dehydroepiandrosteron (DHEA) a hormonální substituční terapie

Creator:
Fingerová, Helena
Type:
model:article, article, Text, and TEXT
Subject:
hormonální substituční terapie--METODY, dehydroepiandrosteron--FARMAKOLOGIE--METABOLISMUS--TERAPEUTICKÉ UŽITÍ, osteoporóza--PATOLOGIE, steroidy--METABOLISMUS, menopauza, výsledek terapie, lidé, dospělí, and ženské pohlaví
Language:
Czech and English
Description:
Helena Fingerová, Lit: 23, and Souhrn: eng
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

6. Estrogen can modulate menopausal women's heart rate variability

Creator:
Yang, S.-G., Mikuláš Mlček, and Otomar Kittnar
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, menopauza, hormonální substituční terapie, srdeční rytmus, menopause, hormone replacement therapy, heart rate, heart rate variability, 14, and 612
Language:
English
Description:
b1_The aim of our study was to compare the responses of heart rate variability (HRV) with two di fferent types of hormonal substitution therapy (HT) in post-menopausal women (cross-sectional study) and to reveal an effect of HT shortly after beginning of its administration (f ollow-up study). To elucidate the influence of menopause and effects of different protocols of a HT on autonomic control of heart rate, we evaluated the heart rate variability (HRV) in 5 groups: premenopausal women (n=140), postmenopausal women without HT (n=360), women on HT with conjugated estrogen only (n =168), women on continuous combined estrogen-progesterone HT (n=117), and men (n=140). Frequency-domain of short-term stationary R-R intervals was performed to evaluate the total variance, low frequency power (LF; 0.04-0.15 Hz), high freque ncy power (HF; 0.15-0.40 Hz), portion of low frequency power (LF%) and ratio of LF to HF (LF/HF). Significantly lower portion of the LF was found in premenopausal women [46.9 (±2.7) nu] when compared to untreated postmenopausal wome n [54.3 (±2.9) nu] and men [55.2 (±3.0) nu]. Treatment by estrogen only was proved to decrease the LF% [40.1 (±2.1) nu] while no effect on HRV was observed in women treated with combination of estrogen and progesterone [57.2 (±3.1) nu]. Also the HF was lower in postmenopausal wome n [4.16 (±0.16) ms 2 ] than in premenopausal women [4.79 (±0.22) ms 2 ] and women treated with estrogen only [4.98 (±0.25) ms 2 ] while in women treated with combined hormonal therapy the average value [3.99 (±0.21) ms 2 ] did not significantly differ from that of untreated postmenopausal women. The follow-up study also proved increase of high frequency power already after two months of estrogen substitution therapy [4.86 (±0.14) ms 2 vs. 4.19 (±0.15) ms 2 ]., b2_These results suggest that hi gher vagal modulation of heart rate that seems typical for younger women becomes after menopause similar to that of men. We also proved a positive shift of HRV parameters toward more beneficial values as for a cardiovascular risk in postmenopausal women treated with estrogens but not in those treated by combined estrogen - progesterone substitution therapy., S.-G. Yang, M. Mlček, O. Kittnar., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

9. Hormonální substituční léčba: rok po publikování výsledků studie WHI

Creator:
Jeníček, Jaroslav and Dvořák, Vladimír
Type:
model:article, article, Text, and TEXT
Subject:
hormonální substituční terapie--DĚJINY--škodlivé účinky, menopauza, výsledek terapie, kvalita života, epidemiologické studie, nádory prsu--EPIDEMIOLOGIE, lidé, dospělí, and ženské pohlaví
Language:
Czech
Description:
Jaroslav Jeníček, Vladimír Dvořák and Lit: 11
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

10. Is A163G polymorphism in the osteoprotegerin gene associated with heel velocity of sound in postmenopausal women?

Creator:
Kateřina Zajíčková, Adéla Zemanová, Martin Hill, and Ivana Žofková
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, endokrinologie, polymorfismus, menopauza, endocrinology, polymorphism, menopause, osteoprotegerin gene, velocity of sound (VOS), broadband ultrasound attenuation, 14, and 612
Language:
English
Description:
Osteoprotegerin (OPG) plays an important inhibitory role in osteoclastogenesis. Polymorphisms in the OPG gene recently have been associated with various bone phenotypes including fractures. The aim of the present study was to investigate the association between three informative OPG polymorphisms and quantitative ultrasound variables of the heel. In a cohort of 165 perimenopausal women polymorphisms in the OPG promoter (A163G, T245G) and in exon 1 (G1181C) were assessed by PCR-RFLP analysis. The distribution of the investigated genotypes was similar to other Caucasian women (A163G-AA 68 %, AG 30 %, GG 2 %, T245G-TT 84.4 %, TG 15 %, GG 0.6 %, G1181C-GG 22 %, CG 55 %, CC 23 %). After adjustment for body mass index and years since menopause, in a subgroup of 87 postmenopausal subjects, calcaneal velocity of sound (VOS, m/s) was significantly associated with A163G polymorphism (p=0.0102, ANCOVA). Women with the presence of G allele (AG+GG genotypes) had significantly lower VOS than women with AA genotype. Neither T245G nor G1181C were associated with calcaneal ultrasound indices. In conclusion, A163G polymorphism was significantly associated with VOS at the heel in a limited cohort of postmenopausal women. The present study replicated in part the previous findings about OPG gene variations and peripheral bone mass in Caucasian women., K. Zajíčková, A. Zemanová, M. Hill, I. Žofková., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public