The effect of oestradiol administration and restricted feeding on longitudinal tibia growth was investigated in immature male rats. The restrictedly fed animals had a significantly longer tibia, greater thickness of the growth plate, faster rate of longitudinal tibial growth as well as the greater rate of [methyl-3H]thymidine incorporation into the growth plate of the tibia compared with oestradiol-treated animals. The results indicate that, in immature male rats, exogenous oestradiol can decrease the longitudinal growth of the tibia (at least partly due to inhibition of cell proliferation in the growth plate) independently of its anorexic effect.
Three new genera containing five new species of Lophopidae are described: Maana colorata, Maana erythina, Maana oriomoensis, Podoschtroumpfa magna and Pseudotyxis malimoenensis. A new key to the genera of Lophopidae is also provided, followed by a cheklist of the distribution of the genera and their host plants.
We have evaluated whether the addition of either bradykinin or histamine favours the lymphatic absorption of human recombinant ¡nterferon-a2 (IFN-cq) administered by the subcutaneous route. Subcutaneous administration of IFN-a2 with bradykinin enhances IFN absorption via both capillaries and lymphatics, so that either the plasma or lymph areas under the concentration curves (ACJC) increase significantly up to 1751 ±483 and 1319±608 l(_l/ml/min respectively as compared to the respective ACJC values (613±208 and 483±213 ICJ/ml/min) obtained after IFN injection in normal saline. Since the lymph ACJC/plasma ACJC ratios remain unaltered, there is no preferential lymphatic absorption of IFN-a2 after bradykinin administration. Dual-label experiments, 125l-IFN-a2 in saline and 131l-IFN-a2 in saline containing 200 jig histamine were injected subcutaneously into the left and into the right shank of the same animal, gave similar results. The kinetics of 125l and 131l acid-soluble radioactivity confirm that histamine favours both plasmatic and lymphatic absorption.
Pharmaceutical industry - one of the few areas in which innovations affect all of us, because ultimately have a direct impact on the duration and quality of life for us and our loved ones. In the presence of a strong market and a lack of understanding of the need for innovation is necessary, in our opinion, investing in basic research and facilitate the process of innovation in the pharmaceutical industry by the state and society. For the targeted development of pharmaceutical industry seems appropriate to determine at the state level prospects for the domestic pharmaceutical industry and its role in the international market, and develop a drug "doctrine" of Russia. This paper analyzed the problems of the state associated with the pharmaceutical market in the globalization period. Also investigated the theoretical aspects of the modern study of globalization in the light of the analysis for the global pharmaceutical industry and analyzes the major political and economic factors that have the most significant impact on the production of pharmaceuticals., Natalia Klunko, Reta Marynia, and Literatura
The male genitalia of the fritillary butterfly Issoria lathonia (L.) were examined and reconstructed based on sagittal and horizontal sections. Nine intrinsic muscles were identified consistent with previous results. The retractor of the anal tube probably operates the "rectal plate", a large, sclerotised, arched plate present ventral to the rectum and dorsal to the phallus in all Issoria s. str. species. The function of the rectal plate is still largely unknown, but it has presumably an important function during copulation. The retractor of the phallus inserts on the phallus, and also on a small, ventral sclerite in the anellus. The retractor of the vesica is smaller in I. lathonia than its counterpart in other Argynnini and originates more centrally inside the phallus. The tergal sclerite, common in most Argynnini, has no attaching muscle and its evolutionary origin remains unclear. The presence of an intrinsic muscle (i3) originating on the tegumen and inserting on the valve in Argynnini cannot be confirmed here. Though generally absent in butterflies, this muscle has been reported once in the North American Argynnis subgenus Speyeria.
The male of Tetanoptera leucodactyla Verbèke, a genus and species of Sciomyzidae known until now only from one female specimen from the Congo, is described, and the genus is more fully characterized. The external morphology is illustrated and the male genitalia are described and figured for the first time. The relationships of Tetanoptera to genera of the Sepedon group and certain other genera of Tetanocerini are discussed. Tetanoptera appears to be related to Verbekaria, and intermediate in an evolutionary lineage between the relatively primitive Tetanocera and the advanced Thecomyia., Lloyd V. Knutson, Jean-Claude Vala, and Lit
Charcot foot neuropathic osteoarthropathy is a disorder affecting the soft tissues, joints, and bones of the foot and ankle. The disease is triggered in a susceptible individual through a process of uncontrolled inflammation leading to osteolysis, progressive fractures and articular malpositioning due to joint subluxations and dislocations. The progression of the chronic deformity with a collapsed plantar arch leads to plantar ulcerations because of increased pressure on the plantar osseous prominences and decreased plantar sensation. Subsequent deep soft tissue infection and osteomyelitis may result in amputation. The Charcot foot in diabetes represents an important diagnostic and therapeutic challenge in clinical practice. Conservative treatment remains the standard of the care for most patients with neuropathic disorder. Offloading the foot and immobilization based on individual merit are essential and are the most important recommendations in the active acute stage of the Charcot foot. Surgical realignment with stabilization is recommended in severe progressive neuropathic deformities consisting of a collapsed plantar arch with a rocker-bottom foot deformity. and P. Sponer, T. Kucera, J. Brtková, J. Srot
This paper investigates the matrix porosity and related properties of a leucocratic granite from the Krudum Massif, West Bohemia. The required samples were obtained from the 30-year old core of borehole KZ-25 (Material Documentation Depositories). In total, nine sample sets were taken from different depth levels within the borehole ranging from 18 m to 108 m. The hydraulic conductivity of the granite matrix was measured using a pressure cell whilst standard methods were employed to determine the dry density, connected porosity and total porosity. The pore size distribution was analysed using mercury porosimetry. The ultrasonic velo cities were measured using a pulse source and oscilloscope. Dynamic Young’s modulus, dynamic shear modulus, Poisson’s ratio, static Young’ s modulus, uniaxial compressive strength and moisture were determined according to measurements of ultrasonic velocities and deformability in uniaxial compression. The morphology and structure of the pore network was studied using high reso lution scanning electron microscopy. The overall porosity values defined by the different porosimetry methods follow the same trends although the absolute values differ according to the specific method. A logarithmic relationship was found to exist between hydraulic conductivity and porosity within the granite matrix. In addition, a slight depth dependence was noted in the porosity, hydraulic conductivity, bulk density, and ultrasonic velocities of the granite matrix. The SEM images have allowed precise mapping and detailed de scription of the pore network., Lucie Nováková, Karel Sosna, Milan Brož, Jan Najser and Petr Novák., and Obsahuje bibliografické odkazy
Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. The mechanism of their action in B cells of the pancreas has been intensively investigated and now is quite well understood. The cytotoxic action of both these diabetogenic agents is mediated by reactive oxygen species, however, the source of their generation is different in the case of alloxan and streptozotocin. Alloxan and the product of its reduction, dialuric acid, establish a redox cycle with the formation of superoxide radicals. These radicals undergo dismutation to hydrogen peroxide. Thereafter highly reactive hydroxyl radicals are formed by the Fenton reaction. The action of reactive oxygen species with a simultaneous massive increase in cytosolic calcium concentration causes rapid destruction of B cells. Streptozotocin enters the B cell via a glucose transporter (GLUT2) and causes alkylation of DNA. DNA damage induces activation of poly ADP-ribosylation, a process that is more important for the diabetogenicity of streptozotocin than DNA damage itself. Poly ADP-ribosylation leads to depletion of cellular NAD+ and ATP. Enhanced ATP dephosphorylation after streptozotocin treatment supplies a substrate for xanthine oxidase resulting in the formation of superoxide radicals. Consequently, hydrogen peroxide and hydroxyl radicals are also generated. Furthermore, streptozotocin liberates toxic amounts of nitric oxide that inhibits aconitase activity and participates in DNA damage. As a result of the streptozotocin action, B cells undergo the destruction by necrosis., T. Szkudelski., and Obsahuje bibliografii
At maturity, the endoparasitoid larvae of several subfamilies of the Braconidae have to emerge from inside of the host to pupate. Although the hosts hormonal milieu and the timing of larval parasitoid emergence have been studied, no report has yet focused on the physiological state of the host in connection with the emergence behavior of endoparasitoids. We investigated the mechanism of larval emergence behavior in a gregarious endoparasitoid, Cotesia kariyai. The parasitoid larvae inserted their mandibles into the host cuticle and perforated the integument by moving their head-capsule backwards and forwards. The emerging parasitoid larva must have a physical support (an "anchor") with the terminal appendages in order to exert the necessary pressure to cut the host integument. Morphological observations revealed that each parasitoid larva was enveloped in a capsule just before emerging from their host. Eight and nine day-old parasitoid larvae secreted material around their bodies to form these capsules. This material consisted of acid-glycoproteins which coated the exuvium of the 2nd instar larvae. The haemolymph volume of the parasitised host also decreased in later stages and was dramatically reduced immediatly prior to parasitoid emergence. This final reduction of the host haemolymph volume is the result of absorption by parasitoid larvae. This mechanism allows the parasitoid larvae to create an anchor more easily. The parasitoid larvae could also adhere to each other with the glycoprotein. In addition, these capsules prevent the leaking of host haemolymph through the emergence hole; these holes on the host integument were plugged by the capsules after parasitoid emergence. Although the pressure acquired by the anchor was lost once the head of the parasitoid larvae emerges from the host integument, the parasitoid larvae crawls out of the host cavity using backward pointing spines which enable the parasitoid to grip the capsule and move forward via peristaltic contractions.