Aerobic exercise showed beneficial influence on cardiovascular systems in aging, and mechanisms underlying vascular adaption remain unclear. Large-conductance Ca2+ -activated K+(BKCa) channels play critical role s in regulating cellular excitability and vascular tone. This study determin ed the effects of aerobic exercise on aging -associated functional changes in BK Ca channels in cerebrovascular myocytes, Male Wistar rats aged 20- 22 mo nths were randomly assigned to sedentary (O -SED), low training frequency (O-EXL), and high training frequency group (O -EXH). Young rats were used as control. Compared to young rats, w hole -cell BK Ca current was decreased, and amplitude of spontaneous transient outward currents were reduced. The open probability and Ca2+/voltage sensitivity of single BK Ca channel were declined in O -SED, accompanied with a reduction of tamoxifen-induced BK Ca activation; the mean open time of BK Ca channels was shortened whereas close time was prolonged. Aerobic exercise training markedly alleviated the aging-associated decline independent of training frequency. Exercise three times rather than five times weekly may be a time and cost-saving training volume required to offer bene ficial effects to offset the functional declines of BK Ca during aging., Na Li, Bailin Liu, Sharon Xiang, Lijun Shi., and Obsahuje bibliografii
This paper preserits a framework for processing heterogeneous information based on the construction of general observational domains, and similarity-based function calculi sutable for data mining in domains which can be described by corresponding observational rnodels. These calculi are intuitive, sirnple, and sufřiciently general for classification and pattern recognition tasks. Functions in these calculi are represented by a particular kind of neuron rnodels and their behavior is illustrated with examples frorn real-world domains showing their capabilities in Processing heterogeneous, incornplete and fuzzy information.
In 1694 Lazar Abeles, a Prague Jew, was accused of murdering his son, Shimon, who had wanted to be baptized. The murder qualifi ed as a crime stemming from ‘hatred for the Christian faith’ (ex odio fi dei). The inhabitants of Prague became fascinated by the case, and as more journalists wrote about the boy’s death tensions between Christians and Jews rose too. Contemporaneous works describe Shimon as a martyr and a new saint, though he had never offi cially converted to Christianity. The case was widely recorded, including in three documents that represent special types of hagiographic literature. The fi rst is the anonymous Czech treatise Inqvisitorní Process (Inquisitorial Proceedings, 1696), a collection of legal, government, and Church records of the Roman Catholic Inquisition. The second is a Latin account by the Jesuit Johannes Eder, Virilis Constantia (Manly Constancy, 1696), a classic hagiographic text. The last is Agnus inter Haedos (A Lamb among the Goats, 1738), a Latin -Czech school play, which was put on at the Jesuit seminary in the New Town, Prague, by grammar -school pupils. In these texts the narrative of Shimon Abeles is adapted to the image of a new martyr by repeated formulas, fi gures of speech, tropes, and topoi. These literary elements were common both to medieval literature and to early modern writing. Analysis of hagiographic commonplaces may show us how the Baroque legend came into being and was then transformed in hagiographic literature because of religious interests. They also reveal stereotypes of Jews, the roots of modern antisemitism.
Šimon Lomnický z Budče ; vydal Engelbert Šubert., Obsahuje bibliografii, Přívazek k : Staročeský rukohled a novočeský rukozpyt / Čeněk Zíbrt, and Desky nejsou k dispozici, použity desky z MVS.