Similar enhancement of BKCa channel function despite different aerobic exercise frequency in aging cerebrovascular myocytes

Title:

Similar enhancement of BKCa channel function despite different aerobic exercise frequency in aging cerebrovascular myocytes

Creator:

Li, Na, Liu, Bailin, Xiang, Sharon, and Shi, Lijun

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4ffeeb7a-b67e-49a1-861e-a5ccc5de6d96
uuid:4ffeeb7a-b67e-49a1-861e-a5ccc5de6d96
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, stárnutí, fyziologie, aging, physiology, BKCa channel, aerobic exercise training, celebral artery, biophysical properties, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Aerobic exercise showed beneficial influence on cardiovascular systems in aging, and mechanisms underlying vascular adaption remain unclear. Large-conductance Ca2+ -activated K+(BKCa) channels play critical role s in regulating cellular excitability and vascular tone. This study determin ed the effects of aerobic exercise on aging -associated functional changes in BK Ca channels in cerebrovascular myocytes, Male Wistar rats aged 20- 22 mo nths were randomly assigned to sedentary (O -SED), low training frequency (O-EXL), and high training frequency group (O -EXH). Young rats were used as control. Compared to young rats, w hole -cell BK Ca current was decreased, and amplitude of spontaneous transient outward currents were reduced. The open probability and Ca2+/voltage sensitivity of single BK Ca channel were declined in O -SED, accompanied with a reduction of tamoxifen-induced BK Ca activation; the mean open time of BK Ca channels was shortened whereas close time was prolonged. Aerobic exercise training markedly alleviated the aging-associated decline independent of training frequency. Exercise three times rather than five times weekly may be a time and cost-saving training volume required to offer bene ficial effects to offset the functional declines of BK Ca during aging., Na Li, Bailin Liu, Sharon Xiang, Lijun Shi., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2016 Volume:65 | Number:3

Harvested from:

CDK

Metadata only:

false