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1152. Anti-CD38 therapy with daratumumab for relapsed/refractory CD20-negative diffuse large B-Cell lymphoma

Creator:
Vockova, P. , Svaton, M. , Karolova, J. , Pokorna, E., Vokurka, M., and Klener, P.
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
Non-Hodgkin lymphomas, CD38, daratumumab, and patient-derived xenograft
Language:
English
Description:
Diffuse large B-cell lymphoma (DLBCL) is the most common and one of the most aggressive subtypes of non-Hodgkin’s lymphomas. Front-line therapy consists of chemotherapy in combination with anti-CD20 monoclonal antibody rituximab. Relapses after rituximab-based regimen have poor prognosis and call for new treatment options. Immunohistochemistry analysis of relapsed DLBCL often reveal CD20-negative lymphoma, which limits repeated use of rituximab in combination with salvage chemotherapy. CD38 is a surface antigen that binds to CD38, CD31/PECAM-1 and hyaluronic acid. CD38 is an important mediator of signal transmission from the microenvironment into the cell. Anti-CD38 monoclonal antibody daratumumab has been approved for the treatment of multiple myeloma. Expression of CD38 on the surface of DLBCL is highly variable (compared to strong expression on myeloma cells), but can be easily assessed by flow cytometry or immunohistochemistry. A patient-derived xenograft (PDX) model of CD20-negative, CD38-positive DLBCL derived from a patient with rituximab-refractory DLBCL was used for in vivo experiments. We demonstrated that daratumumab suppressed growth of subcutaneous PDX tumours significantly more effectively than rituximab. Analysis of tumours obtained from mice treated with daratumumab revealed down-regulation of surface CD38, suggesting endocytosis of CD38-daratumumab complexes. The results suggest a potential clinical use of daratumumab in combination with salvage chemotherapy in patients with relapses of CD20-negative DLBCL. In addition, daratumumab might potentially serve as a suitable antibody moiety for derivation of antibodydrug conjugates for the targeted delivery of toxic payloads to the lymphoma cells.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

1153. Anti-rómsky bilbord: analýza obrazu a médií

Creator:
Jana Plichtová and Paholíková, Vlasta
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Psychologie, psychologie, rasismus, stereotypy, racism, stereotypes, kritická systemická lingvistika, kritická diskurzívna analýza, anti-rómsky populizmus, dehonestácia, stigmatizácia, critical systemic linguistics, critical discursive analysis, anti-Roma populism, dehonestation, stigmatization, 17, and 159.9
Language:
Czech
Description:
Štúdia sa kriticky zaoberá diskurzívnymi aktivitami politikov a novinárov, ktorí slúžia ako modely pre imitáciu potvrdzovania, alebo naopak oponovania negatívnym stereotypom voči Rómom. Empiricky overuje tézu, že mediálny marketing politických strán zneužíva diskriminované a marginalizované skupiny na dosahovanie straníckych cieľov. Prostredníctvom kritickej systemickej lingvistiky analyzuje významové štruktúry predvolebného bilbordu, čím odhaľuje intencie komunikácie politickej strany s verejnosťou. Postupmi kritickej diskurzívnej analýzy mediálnych textov o anti-rómskom bilborde autorky identifikujú diskurzívne pozície rozmanitých aktérov, prípadne ich argumentačné stratégie, pričom kriticky reflektujú najmä asymetriu ich mediálnej prezentácie. Popisujú Diskuze / 401 sa spôsoby, akými parlamentná strana SNS implicitne (prostredníctvom bilbordu) a explicitne (vo svojich vyjadreniach) znevažuje celú etnickú skupinu. Z analýzy vyplýva, že hoci médiá uvádzajú názory rôznych diskurzívnych aktérov, v textoch chýba prezentácia argumentov, ktoré by pomohli širokej verejnosti pochopiť, prečo dehonestácia tejto stigmatizovanej skupiny je neprijateľná. Politické zneužívanie „rómskeho problému“ novinári demaskovali, avšak nevysvetlili negatívne dôsledky falošnej etnizácie nezamestnanosti, chudoby a verejnej dehonestácie Rómov., The study deals critically with discursive activities of politics and newspapermen which serve as models for imitation of confirmation or on the contrary of opposing the negative stereotypes against Roma. The thesis that the media marketing of political parties misuses the discriminated and marginalized groups for achieving the party goals is empirically verified. The meaning structures of pre-election billboard are analyzed by the means of critical systemic linguistics and thus reveals the intentions of communication of political party with the public. The authors identify the discursive positions of diverse participants, alternatively their argumentation strategies, and critically reflect especially the asymmetry of their media presentation by procedures of critical discursive analysis of media texts about the anti-Roma billboard. The ways how the parliament party SNS implicitly (through the billboard) and explicitly (in its statements) discredit the whole ethnic group are described. From the analysis follows that although media present the opinions of different discourse participants, the texts are lacking the presentation of arguments that could help the wide public to understand why the dehonestation of this stigmatized group is unacceptable. The political misuse of „Roma problem“ was unmasked by newspapermen but the negative consequences of false ethnic attribution of unemployment, poverty, and public dehonestation of Roma were not explained., Jana Plichtová, Vlasta Paholíková., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

1154. Anti-spurious-state neural network using nonlinear outer product and dynamic synapses

Creator:
XIa, M., Shen, M., Wang, J., Weng, L., and Yan , C.
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
associative memory, spurious state, nonlinear function constitution, and dynamic synapse
Language:
English
Description:
Associative memory (AM) is a very important part of the theory of neural networks. Although the Hebbian learning rule is always used to model the associative memory, it easily leads to spurious state because of the linear outer product method. In this work, nonlinear function constitution and dynamic synapses, against a spurious state for associative memory neural network are proposed. The model of the dynamic connection weight and the updating scheme of the states of neurons are presented. Nonlinear function constitution improves the conventional Hebbian learning rule to be a nonlinear outer product method. The simulation results show that both nonlinear function constitution and dynamic synapses can effectively enlarge the attractive basin. Comparing to the existing memory models, associative memory of neural network with nonlinear function constitution can both enlarge the attractive basin and increase the storage capacity. Owing to dynamic synapses, the attractive basin of the stored patterns is further enlarged, at the same time the attractive basin of the spurious state is diminished. But the storage capacity is decreased by using the dynamic synapses.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

1155. Anti-suit injunctions in arbitral and judicial procedures in the Czech Republic

Creator:
Alexander J Bělohlávek
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
Česko., ordre public, rozhodčí smlouvy, ústavní právo, jurisdikce, překážka věci pravomocně rozhodnuté, arbitration agreements, constitutional law, jurisdiction, res judicata, anti-suit injunctions, anti-arbitration injunctions, recognition and enforcement of judgements, recognition and enforcement of arbitral awards, arbitration, Charter of Fundamental Rights, Kompetenz-Kompezenz, Lis Pendens, procedural conditions, objective arbitrability, 16, and 34
Language:
English
Description:
Anti-suit injunctions are rather unknown in the civil law legal system of the Czech Repbulic. The policy reasons for the rejection of anti-suit injunctions in the Czech Republic are rooted in the constitutional right of every person to assert, through the legally prescribed procedure, their rights before an independent and impartial court or, in specified cases, before another body. In other words, every person may commence proceedings before a competent court, or respectively before any court or another body (e.g. like an arbitral tribunal, etc.), which is then exclusively empowered to rule on its jurisdiction. Therefore, there is also no distinction between anti-suit injunctions in domestic and international litigation. Czech law does not have any alternative procedural or substantive devices that may have similar functions as anti-suit injunctions related to arbitration. It means that it is not possible to obtain a court order against a respondent prohibiting the respondent from commencing or continuing court proceedings in another forum in violation of an arbitration agreement., Alexander J. Bělohlávek., and Obsahuje bibliografické odkazy
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

1156. Antiassociative groupoids

Creator:
Braitt, Milton, Hobby, David, and Silberger, Donald
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
groupoid and unification
Language:
English
Description:
Given a groupoid hG, ⋆i, and k ≥ 3, we say that G is antiassociative if an only if for all x1, x2, x3 ∈ G, (x1 ⋆ x2) ⋆ x3 and x1 ⋆ (x2 ⋆ x3) are never equal. Generalizing this, hG, ⋆i is k-antiassociative if and only if for all x1, x2, . . . , xk ∈ G, any two distinct expressions made by putting parentheses in x1 ⋆ x2 ⋆ x3 ⋆ . . . ⋆ xk are never equal. We prove that for every k ≥ 3, there exist finite groupoids that are k-antiassociative. We then generalize this, investigating when other pairs of groupoid terms can be made never equal.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

1159. Antibodies targeting human endothelin-1 receptors reveal different conformational states in cancer cells

Creator:
Herbet, A., Costa, N., Boquet, D., Hugnot, J.-P., Borrull, A., Couraud, J.-Y., Mabondzo, A., and Leventoux, N.
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
fyziologie člověka, human physiology, Monoclonal antibodies, Endothelin-1, Endothelin B receptor, Endothelin A receptor, 14, and 612
Language:
English
Description:
The endothelin axis (endothelins and their receptors) is strongly involved in physiological and pathological processes. ET-1 plays a crucial role in particular in tumor diseases. Endothelin-1 receptors (ETA and ETB) are deregulated and overexpressed in several tumors such as melanoma and glioma. We studied the binding of 24 monoclonal antibodies directed against human ETB receptors (hETB) to different melanoma cell lines. Few of these mAbs bound to all the melanoma cell lines. One of them, rendomab B49, bound to ETB receptors expressed at the surface of human glioma stem cells. More recently, we produced new antibodies directed against human ETA receptor (hETA). Several antibodies have been isolated and have been screened on different tumoral cells lines. As for the mAbs directed against the hETB receptor only some of new antibodies directed against ETA receptor are capable to bind the human tumoral cell lines. Rendomab A63 directed against hETA is one of them. We report the specificity and binding properties of these mAbs and consider their potential use in diagnosis by an in vivo imaging approach., A. Herbet, N. Costa, N. Leventoux, A. Mabondzo, J.-Y. Couraud, A. Borrull, J.-P. Hugnot, D. Boquet., and Seznam literatury
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

1160. Antimonachismus v české osvícenské společnosti: obsahová analýza tří antimonachistických brožur

Creator:
Hasan, Petr
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
církevní dějiny, osvícenství, lidská přirozenost, askeze, church history, enlightenment, human naturalness, asceticism, antimonachismus, antimonachism, 8, and 94(437)
Language:
Czech and English
Description:
This study deals with reforms by Josef II, in particular with the abolition of the monasteries as recorded in contemporary sources supporting the reforms being carried out. The author selects some significant themes treated by the proponents of reform. The main theme is the criterion of human nature. Related themes include: monks’ asceticism, celibacy, monasteries as the quintessence of baroque piety, and mendicant orders., Petr Hasan., and Obsahuje bibliografické odkazy
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

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